Risk of long covid in patients with pre-existing chronic respiratory diseases: a systematic review and meta-analysis

BMJ Open Respiratory Research, Journal Year: 2025, Volume and Issue: 12(1), P. e002528 - e002528

Published: Jan. 1, 2025

Background An estimated 10–30% of people with COVID-19 experience debilitating long-term symptoms or long covid. Underlying health conditions associated chronic inflammation may increase the risk Methods We conducted a systematic review and meta-analysis to examine whether covid was altered by pre-existing asthma obstructive pulmonary disease (COPD) in adults. identified studies searching PubMed Embase databases from inception 13 September 2024. excluded that focused on children defined only terms respiratory symptoms. used random-effects, restricted maximum likelihood models analyse data pooled 51 studies, which included 43 analyses 30 COPD. The bias assessed using ROBINS-E table. Results found 41% increased odds (95% CI 1.29 1.54); COPD 32% 1.16 1.51). Pre-existing asthma, but not COPD, covid-associated fatigue. observed heterogeneity results related hospitalisation status. Potential confounding inconsistent measurement exposure outcome variables were among limitations. Conclusions Our findings support hypothesis covid, including fatigue outcomes patients asthma. Because targets tract, these inflammatory lower tract could provide mechanistic clues common pathway for development sequelae

Language: Английский

---

Liquid biomarkers of macrophage dysregulation and circulating spike protein illustrate the biological heterogeneity in patients with post‐acute sequelae of COVID‐19

Journal of Medical Virology, Journal Year: 2022, Volume and Issue: 95(1)

Published: Dec. 2, 2022

Post-acute sequelae of COVID-19 (PASC) are long-term consequences SARS-CoV-2 infection that can substantially impair the quality life. Underlying mechanisms ranging from persistent viruses to innate and adaptive immune dysregulation have been discussed. Here, we profiled plasma 181 individuals cohort study for digital health research in Germany (DigiHero), including after mild moderate with or without PASC uninfected controls. We focused on soluble factors related monocyte/macrophage biology circulating spike (S1) protein as a potential biomarker viral reservoirs. At median time 8 months infection, found pronounced almost all tested factors, both pro-inflammatory pro-fibrotic cytokines. These immunological perturbations were remarkably independent ongoing symptoms per se, but further correlation regression analyses suggested PASC-specific patterns involving CCL2/MCP-1 IL-8 either correlated sCD162, sCD206/MMR, IFN-α2, IL-17A IL-33, IL-18 IL-23. None analyzed detectability levels S1, indicating this represents an subset patients PASC. data confirm prior evidence persistence illustrate its biological heterogeneity still awaits clinically defined subtypes.

Language: Английский

---

COVID‐19 immunopathology: From acute diseases to chronic sequelae

Journal of Medical Virology, Journal Year: 2022, Volume and Issue: 95(1)

Published: Sept. 3, 2022

The clinical manifestation of coronavirus disease 2019 (COVID-19) mainly targets the lung as a primary affected organ, which is also critical site immune cell activation by severe acute respiratory syndrome 2 (SARS-CoV-2). However, recent reports suggest involvement extrapulmonary tissues in COVID-19 pathology. interplay both innate and adaptive responses key to management. As result, robust response provides first line defense, concomitantly, immunity neutralizes infection builds memory for long-term protection. dysregulated immunity, adaptive, can skew towards immunopathology chronic cases. Here we have summarized some findings that provide insight into caused SARS-CoV-2, post-acute Finally, further discuss immunomodulatory drugs preclinical trials dampening COVID-19.

Language: Английский

---

The role of immune activation and antigen persistence in acute and long COVID

Journal of Investigative Medicine, Journal Year: 2023, Volume and Issue: 71(5), P. 545 - 562

Published: March 6, 2023

In late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) triggered the global disease 2019 (COVID-19) pandemic. Although most infections cause a self-limited comparable to other upper viral pathogens, portion of individuals develop illness leading substantial morbidity and mortality. Furthermore, an estimated 10%–20% SARS-CoV-2 are followed by post-acute sequelae COVID-19 (PASC), or long COVID. Long COVID is associated with wide variety clinical manifestations including cardiopulmonary complications, persistent fatigue, neurocognitive dysfunction. Severe hyperactivation increased inflammation, which may be underlying in subset individuals. However, immunologic mechanisms driving development still under investigation. Early pandemic, our group others observed immune dysregulation persisted into convalescence after COVID-19. We subsequently cohort experiencing demonstrated SARS-CoV-2-specific CD4 + CD8 T-cell responses antibody affinity patients symptoms. These data suggest symptoms due chronic activation presence antigen. This review summarizes literature date detailing how these observations relate addition, we discuss recent findings support antigen evidence that this phenomenon contributes local systemic inflammation heterogeneous nature seen

Language: Английский

---

Long term neuropsychiatric consequences in COVID-19 survivors: Cognitive impairment and inflammatory underpinnings fifteen months after discharge

Asian Journal of Psychiatry, Journal Year: 2022, Volume and Issue: 80, P. 103409 - 103409

Published: Dec. 15, 2022

Language: Английский

---