Preconceptional maternal hyperandrogenism and metabolic syndrome risk in male offspring: a long-term population-based study

Journal of Endocrinological Investigation, Journal Year: 2024, Volume and Issue: 47(11), P. 2731 - 2743

Published: April 22, 2024

Language: Английский

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X centromeric drive may explain the prevalence of polycystic ovary syndrome and other conditions

BioEssays, Journal Year: 2024, Volume and Issue: 46(9)

Published: July 29, 2024

Abstract X chromosome centromeric drive may explain the prevalence of polycystic ovary syndrome and contribute to oocyte aneuploidy, menopause, other conditions. The mammalian be vulnerable meiotic because inactivation in female germline. human pericentromeric region contains genes potentially involved mechanisms, including multiple SPIN1 ZXDC paralogs. This is consistent with a multigenic system comprising differential modification active inactive centromeres primordial germ cells preferential segregation previously inactivated centromere polar body at meiosis I. mechanism differences regulation germlines mouse and, based on functions encoded by region, transmission genetic or epigenetic variants progeny could preeclampsia, autism, sexual differentiation.

Language: Английский

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Research on the self-healing ability of polycystic ovarian syndrome (PCOS) in mice model and its impact on offspring

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 13, 2024

Polycystic ovarian syndrome (PCOS) is a prevalent metabolic endocrine disorder in reproductive-age women. This study aims to investigate the self-healing ability of PCOS and its potential impact on offspring. Methods: Female C57 BL/6J mice aged 4-5 weeks were administered letrozole (1 mg/kg/d) high-fat diet for 21 days establish model, control group was established. After modeling, divided into model group. 14 days, mated, growth their offspring recorded. Subsequently, all euthanized collect serum, ovaries, testes. The results showed that phenotype has shown improvement when compared findings from indicate died, while had with lower weight at 7 higher blood glucose levels. Additionally, testicular morphology male poor. conclusion drawn that, after removing pathogenic factors, can self-heal. However, fertility remains impaired, which an

Language: Английский

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The landscape of alternative splicing in granulosa cells and a potential novel role of YAP1 in PCOS

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(12), P. e0315750 - e0315750

Published: Dec. 13, 2024

Polycystic ovary syndrome (PCOS) is a prevalent yet complex reproductive endocrine disorder affecting 11–13% of women worldwide. Its main symptoms include elevated androgen levels, irregular menstrual cycles, and long-term metabolic offspring health implications. Despite the disease’s multifaceted nature involving genetic, epigenetic, environmental factors, role alternative splicing in ovarian granulosa cells remains relatively unexplored. This study aims to investigate transcriptional characteristics PCOS patients elucidate potential functional consequences these changes. Analysis previous published transcriptome sequencing data identified 491 upregulated 401 downregulated genes patients, significantly involved immune-related processes. Additionally, 1250 differential events, predominantly exon skipping 947 genes, were detected. These with patterns found be enriched endoplasmic reticulum stress protein post-translational modification processes, suggesting their pathology. Moreover, highlighted that utilization different splice isoforms YAP1 gene may impact its interaction Hippo signaling pathway, influencing pathogenesis PCOS. findings underscore substantial alterations providing novel viewpoint for comprehending molecular underpinnings avenues therapeutic intervention.

Language: Английский

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PCOS - the many faces of a disorder in women and men

Journal of Endocrinological Investigation, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Language: Английский

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