Design, printing, and engineering of regenerative biomaterials for personalized bone healthcare

Progress in Materials Science, Journal Year: 2023, Volume and Issue: 134, P. 101072 - 101072

Published: Jan. 16, 2023

Language: Английский

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Emerging carbon-supported single-atom catalysts for biomedical applications

Matter, Journal Year: 2022, Volume and Issue: 5(10), P. 3341 - 3374

Published: Oct. 1, 2022

Language: Английский

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Triggered release of antimicrobial peptide from microneedle patches for treatment of wound biofilms

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 356, P. 131 - 141

Published: March 3, 2023

Language: Английский

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Friends against the Foe: Synergistic Photothermal and Photodynamic Therapy against Bacterial Infections

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(4), P. 1116 - 1116

Published: March 31, 2023

Multidrug-resistant (MDR) bacteria are rapidly emerging, coupled with the failure of current antibiotic therapy; thus, new alternatives for effectively treating infections caused by MDR required. Hyperthermia-mediated photothermal therapy (PTT) and reactive oxygen species (ROS)-mediated photodynamic (PDT) have attracted extensive attention as antibacterial therapies owing to advantages such low invasiveness, toxicity, likelihood causing bacterial resistance. However, both strategies notable drawbacks, including high temperature requirements PTT weak ability PDT-derived ROS penetrate target cells. To overcome these limitations, a combination PDT has been used against bacteria. In this review, we discuss unique benefits limitations The mechanisms underlying synergistic effects PTT–PDT also discussed. Furthermore, introduced advancements in methods using nano-based agents treat Finally, highlight existing challenges future perspectives We believe that review will encourage PTT- PDT-based research can be referenced clinical applications.

Language: Английский

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Smart and versatile biomaterials for cutaneous wound healing

Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)

Published: Feb. 9, 2023

The global increase of cutaneous wounds imposes huge health and financial burdens on patients society. Despite improved wound healing outcomes, conventional dressings are far from ideal, owing to the complex process. Smart dressings, which sensitive or interact with changes in condition environment, have been proposed as appealing therapeutic platforms effectively facilitate healing. In this review, processes features existing biomaterials firstly introduced, followed by summarizing mechanisms smart responsive materials. Afterwards, recent advances designs versatile materials extensive applications for were submarined. Finally, clinical progresses, challenges future perspectives dressing discussed. Overall, mapping composition intrinsic structure their individual needs wounds, particular attention mechanisms, review is promising advance further progress designing drive translation.

Language: Английский

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In Situ Embedding Hydrogen‐Bonded Organic Frameworks Nanocrystals in Electrospinning Nanofibers for Ultrastable Broad‐Spectrum Antibacterial Activity

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(20)

Published: Feb. 15, 2023

Abstract In the event of a public health crisis, highly effective and sustainable antimicrobial materials equipment will be urgently needed. Here, preparation is reported by electrospinning broad‐spectrum antibacterial nanofibers embedded in photoactive hydrogen‐bonded organic framework (HOF) rod‐like nanocrystals ≈60 nm length. The resulting HOF@PVDF‐HFP maintain excellent tensile breathability characteristics while shielding HOF against acid alkali corrosion. A series with different amounts types are prepared to optimize their efficiency singlet oxygen ( 1 O 2 ) generation. 0.5 wt.% HOF‐101‐F@PVDF‐HFP exhibit most efficient generation that enhanced factor almost when compared HOF‐101‐F microcrystalline powder. demonstrated effectively kill pathogens, including viruses, bacteria, fungi 30 min under ambient light conditions.

Language: Английский

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Prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections

Bone Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: May 14, 2024

Osteomyelitis is a devastating disease caused by microbial infection in deep bone tissue. Its high recurrence rate and impaired restoration of deficiencies are major challenges treatment. Microbes have evolved numerous mechanisms to effectively evade host intrinsic adaptive immune attacks persistently localize the host, such as drug-resistant bacteria, biofilms, persister cells, intracellular small colony variants (SCVs). Moreover, microbial-mediated dysregulation microenvironment impedes regeneration process, leading defect repair. Despite advances surgical strategies drug applications for treatment infections within last decade, remain clinical management. The development application tissue engineering materials provided new infections, but comprehensive review their research progress lacking. This discusses critical pathogenic microbes skeletal system immunomodulatory effects on regeneration, highlights prospects technologies infections. It will inform translation antimicrobial repair management

Language: Английский

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Engineering Atomic Ag₁–N₆ Sites with Enhanced Performance of Eradication Drug-Resistant Bacteria over Visible-Light-Driven Antibacterial Membrane

ACS Nano, Journal Year: 2024, Volume and Issue: 18(9), P. 7074 - 7083

Published: Feb. 22, 2024

Utilizing visible light for water disinfection is a more convenient, safe, and practical alternative to ultraviolet-light sterilization. Herein, we developed silver (Ag) single-atom anchored g-C3N4 (P-CN) nanosheets (Ag1/CN) then utilized spin-coating method fabricate the Ag1/CN-based-membrane effective antibacterial performance in natural domestic wastewater. The incorporated Ag single atom formed Ag1–N6 motif, which increased charge density around N atoms, resulting built-in electric field ∼17.2 times stronger than that of pure P-CN optimizing dynamics reactive oxygen species (ROS) production. Additionally, motif inhibited release ions, ensuring good biocompatibility. Based on first-principles calculation, adsorption energy O2 Ag1/CN (−0.32 eV) was lower (−0.07 eV), indicating loaded can barrier activation, generating extra *OH radicals cooperated with *O2– effectively neutralize bacteria. As result, powder-catalyst concentration 30 ppm demonstrated 99.9% efficiency against drug-resistant bacteria (Escherichia coli, Staphylococcus aureus, kanamycin-resistant Escherichia methicillin-resistant aureus) under visible-light irradiation 4 h. This efficacy 24.8 higher powder catalyst. Moreover, maintain bactericidal wastewater treatment using homemade flow device, demonstrating its potential disinfection. Notably, visible-light-driven catalyst outperformed majority reported g-C3N4-based catalysts/membranes.

Language: Английский

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Disruption of Communication: Recent Advances in Antibiofilm Materials with Anti-Quorum Sensing Properties

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(11), P. 13353 - 13383

Published: March 11, 2024

Biofilm contamination presents a significant threat to public health, the food industry, and aquatic/marine-related applications. In recent decades, although various methods have emerged combat biofilm contamination, intricate persistent nature of biofilms makes complete eradication challenging. Therefore, innovative alternative solutions are imperative for addressing formation. Instead solely focusing on mature biofilms, strategically advantageous measures involve delay or prevention formation surfaces. Quorum sensing, communication system enabling bacteria coordinate their behavior based population density, plays pivotal role in numerous microbial species. Materials possessing antibiofilm properties that target quorum sensing gained considerable attention potential prevent This Review consolidates research progress utilization materials with antiquorum combating These can be categorized into three distinct types: (i) nanomaterials, (ii) surfaces, (iii) hydrogels capabilities. Finally, concludes brief discussion current challenges outlines avenues future research.

Language: Английский

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Photo-Sono Interfacial Engineering Exciting the Intrinsic Property of Herbal Nanomedicine for Rapid Broad-Spectrum Bacteria Killing

ACS Nano, Journal Year: 2021, Volume and Issue: 15(11), P. 18505 - 18519

Published: Nov. 5, 2021

Large doses and long duration are often required for herbal medicines to kill bacteria effectively. Herein, a photoacoustic interfacial engineering strategy was utilized endow curcumin (Cur, kind of medicine) with rapid highly effective bacteria-killing efficacy, in which Cur combined CuS form hybrid material CuS/Cur tight contact through situ nucleation growth on the petaloid surface. Due different work functions Cur, electrons were redistributed, i.e., large number gathered side CuS. In contrast, holes after contact. An internal electric field formed drive excited transfer from thus enhancing separation electron–hole pairs. Besides exerting drug nature itself, also had photo–sono responsive ability, endowed photothermal, photodynamic, sonodynamic effects. Therefore, this Cur-based killed 99.56% Staphylococcus aureus 99.48% Escherichia coli under 808 nm near-infrared light irradiation ultrasound successively 15 min, ascribed synergy ROS, hyperthermia, released Cu2+ together properties Cur. This provides enhance therapeutic effects against pathogenic bacterial infections by exciting intrinsic as materials strategy.

Language: Английский

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