Advances in the Potential of Quinoline‐Derived Metal Complexes as Antimalarial Agents: A Review DOI Open Access
Carla Peron, Raoni S. B. Gonçalves, Sidnei Moura

et al.

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(3)

Published: Feb. 11, 2025

ABSTRACT Quinolines obtained from native trees of South and Central America, the genus Cinchona , have been used since 17th century for treatment malaria. However, it was only in 1820 that quinine had its structure elucidated, subsequently, during 20th century, several synthetic derivatives were produced with superior activities. In parallel, search synthesis metal complex compounds malaria dates 1994, development ferroquine, an iron derived chloroquine, developed by Biot collaborators at Lille University. After, there are complexes synthesized various metals, such as ruthenium, gold, iridium, platinum, over last 30 years, which aims this review. This review identified 84 quinoline–metal reported across 25 studies, gold (Complex 63) showing significant potency against FcBI strain (IC 50 10 nM), outperforming chloroquine (CQ, indicating coordination enhances drug's action. The ruthenium 03) exhibited activity PFB but less effective than CQ 22.5 vs. 8.2 nM). Other complexes, Au(III) 61), Ir(I) 52), Ir(II) 50), also demonstrated promising results varying effectiveness different strains. Structural features, including linear geometry Au(I) square planar or piano stool geometries Ru(II) Ir play crucial roles influencing their biological activity. These findings highlight potential improving antimalarial efficacy.

Language: Английский

Platinum and Palladium Complexes as Promising Sources for Antitumor Treatments DOI Open Access
Robert Czarnomysy, Dominika Radomska, Olga Szewczyk‐Roszczenko

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(15), P. 8271 - 8271

Published: July 31, 2021

There is a need for new, safer, and more effective agents to treat cancer. Cytostatics that have transition metals at their core attracted renewed interest from scientists. Researchers are attempting use chemotherapeutics, such as cisplatin, in combination therapy (i.e., order enhance effectiveness). Moreover, studies being carried out modify molecules, by developing them into multinuclear structures, linking different compounds commonly used drugs, or encapsulating nanoparticles improve pharmacokinetic parameters, increase the selectivity of these drugs. Therefore, we attempted organize recent drug findings contain palladium platinum atoms structures.

Language: Английский

Citations

86
Bioactivity and Development of Small Non-Platinum Metal-Based Chemotherapeutics DOI Creative Commons
Maria Grazia Ferraro, Marialuisa Piccolo, Gabriella Misso

et al.

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(5), P. 954 - 954

Published: April 28, 2022

Countless expectations converge in the multidisciplinary endeavour for search and development of effective safe drugs fighting cancer. Although they still embody a minority pharmacological agents currently clinical use, metal-based complexes have great yet unexplored potential, which probably hides forthcoming anticancer drugs. Following historical success cisplatin congeners, but also taking advantage conventional chemotherapy limitations that emerged with applications clinic, design non-platinum chemotherapeutics, either as or prodrugs, represents rapidly evolving field wherein candidate compounds can be fine-tuned to access interactions druggable biological targets. Moving this direction, over last few decades platinum family metals, e.g., ruthenium palladium, been largely proposed. Indeed, transition metals molecular platforms where originate are endowed unique chemical features based on, not limited to, redox activity coordination geometries, well ligand selection (including their inherent reactivity bioactivity). Herein, current progress chemoth reviewed. Converging on recent literature, new attractive chemotherapeutics other than platinum—and bioactivity mechanisms action—are examined discussed. A special focus is committed ruthenium, rhodium, iridium, gold derivatives, more experimental data nowadays available. Next platinum-based agents, ruthenium-based were first reach stage evaluation humans, opening scenarios alternative chemotherapeutic options treat

Language: Английский

Citations

56
Developing a Multitargeted Anticancer Palladium(II) Agent Based on the His-242 Residue in the IIA Subdomain of Human Serum Albumin DOI
Wenjuan Li, Shanhe Li, Zhenlei Zhang

et al.

Journal of Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 66(13), P. 8564 - 8579

Published: June 15, 2023

To obtain next-generation metal drugs that can overcome the deficiencies of platinum (Pt) and treat cancer more effectively, we proposed to develop a multitargeted palladium (Pd) agent tumor microenvironment (TME) based on specific residue(s) human serum albumin (HSA). this end, optimized series Pd(II) 2-benzoylpyridine thiosemicarbazone compounds Pd (5b) with significant cytotoxicity. The HSA-5b complex structure revealed 5b bound hydrophobic cavity in HSA IIA subdomain then His-242 replaced leaving group (Cl) 5b, coordinating center. vivo results showed 5b/HSA-5b had capacity inhibiting growth, therapeutic behavior 5b. In addition, confirmed inhibited growth through multiple actions different components TME: killing cells, angiogenesis, activating T cells.

Language: Английский

Citations

33
Recent Advances in Bioconjugated Transition Metal Complexes for Cancer Therapy DOI Creative Commons
Enrica Bortolamiol, Fabiano Visentin, Thomas Scattolin

et al.

Applied Sciences, Journal Year: 2023, Volume and Issue: 13(9), P. 5561 - 5561

Published: April 29, 2023

The introduction of biologically relevant organic moieties in the coordination sphere transition metal complexes has recently become a well-established strategy to increase selectivity and biocompatibility metallodrugs. In this review, major advances achieved area research last three years are described detail. Particular attention is given bearing main biomolecules life: carbohydrates, lipids, nucleotides, proteins vitamins. Each paragraph summarizes synthetic employed obtain interest as well most interesting biological results obtained with these potential Moreover, structure–activity relationships observed by different groups discussed, goal suggesting reader ligand/metal centre combinations that provide promising fight against cancer. Some compounds examined review other bioconjugated published recent decades exhibit towards cancer cells over normal ones specific mode action. These latter aspects basis what commonly known anticancer target therapy.

Language: Английский

Citations

24
Advances in the Synthesis and Applications of N-Heterocyclic Carbene Metal Complexes with a Focus on the Weak Base Route DOI
Thomas Scattolin, Aleksei A. Logvinov, Nikolaos V. Tzouras

et al.

Organometallics, Journal Year: 2023, Volume and Issue: 42(19), P. 2692 - 2730

Published: Sept. 21, 2023

N-heterocyclic carbene (NHC) ligands have evolved from being simple lab curiosities to tertiary phosphine mimics finally take center stage as unique supporting in organometallic chemistry, homogeneous catalysis, and more recently medicinal chemistry materials science applications. Some of these aspects are presented here a perspective researchers that been fascinated by the area for quite some time.

Language: Английский

Citations

24
A highly cytotoxic Pd(II) saccharinate complex with tris(2-pyridylmethyl)amine acting through mitochondrial and ROS-induced DNA damage DOI
Ceyda İçsel, Şeyma Aydınlık, Muhíttín Aygün

et al.

Inorganica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 122590 - 122590

Published: Feb. 1, 2025

Language: Английский

Citations

1
Unlocking the Potential of Organopalladium Complexes for High-Grade Serous Ovarian Cancer Therapy DOI Creative Commons
Thomas Scattolin, Enrico Cavarzerani, Dario R. Alessi

et al.

Dalton Transactions, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

High-Grade Serous Ovarian Cancer (HGSOC) is the most common and lethal subtype of ovarian cancer, known for its high aggressiveness extensive genomic alterations.

Language: Английский

Citations

1
Folic acid conjugated chitosan encapsulated palladium nanoclusters for NIR triggered photothermal breast cancer treatment DOI
Anbazhagan Sathiyaseelan, Kandasamy Saravanakumar, Panchanathan Manivasagan

et al.

Carbohydrate Polymers, Journal Year: 2021, Volume and Issue: 280, P. 119021 - 119021

Published: Dec. 23, 2021

Language: Английский

Citations

56
Reactivity of Palladium(II)-η3-Allyl Complexes with Chalcogenolates: A Density Functional Study of Their Antitumor Implications DOI

Andrea Madabeni,

Thomas Scattolin, Enrica Bortolamiol

et al.

Organometallics, Journal Year: 2024, Volume and Issue: 43(9), P. 954 - 962

Published: April 18, 2024

Palladium complexes are emerging as potential antitumor compounds. Recent experimental evidence suggests that the mechanism of action some organopalladium derivatives might involve target proteins such Thioredoxin Reductase (TrxR). In this work, we investigate different possible chemical mechanisms interaction between selected palladium(II)-η3-allyl and thiolates or selenolates, which key functional groups present in catalytic pocket TrxR. Our investigation, focusing on both anionic cationic complexes, all cases, species chalcogenolates occurs via a ligand exchange reaction, leads to formation new Pd–S Pd–Se bond. Allyl substitution, takes place with C–S C–Se bond, always appears be least favored from kinetic thermodynamic points view.

Language: Английский

Citations

7
Revisiting metallodrugs for the treatment of skin cancers DOI Creative Commons
Carlos Marrote Manzano, Douglas Hideki Nakahata, Raphael Enoque Ferraz de Paiva

et al.

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 462, P. 214506 - 214506

Published: March 19, 2022

Metallodrugs were classically screened against skin cancer (either in vitro or vivo) at the peak of development platinum anticancer agents. New systematic studies appeared past two decades. Herein, we cover most recent literature concerning metal complexes treatment cancers, including vitro, vivo and clinical data. We have compiled antitumoral potency for each compound every cell line originally tested a table. This smart table has been deposited open access repository Zenodo it can be accessed https://zenodo.org/record/5055531. Structure-activity relationships based on careful analysis databases allowed us to discuss possible lead coordination chemotherapy. Additionally, advances made understanding composition, photodynamic therapies, immunological responses elicited by metals molecular mechanisms cancers. Skin carcinomas represent an excellent prototype looking into developing metallodrug-based therapy (PDT) strategies developments towards that purpose are also covered here. With substantial gained those areas, believe this is perfect moment revisiting metallodrugs as viable alternatives how introduce selectivity. In context, explore major unique chemical composition outer layers alterations observed keratinocyte (KCs) melanoma new designing selective Signalling pathways either KCs explored.

Language: Английский

Citations

23