Advances in the Potential of Quinoline‐Derived Metal Complexes as Antimalarial Agents: A Review DOI Open Access
Carla Peron, Raoni S. B. Gonçalves, Sidnei Moura

et al.

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(3)

Published: Feb. 11, 2025

ABSTRACT Quinolines obtained from native trees of South and Central America, the genus Cinchona , have been used since 17th century for treatment malaria. However, it was only in 1820 that quinine had its structure elucidated, subsequently, during 20th century, several synthetic derivatives were produced with superior activities. In parallel, search synthesis metal complex compounds malaria dates 1994, development ferroquine, an iron derived chloroquine, developed by Biot collaborators at Lille University. After, there are complexes synthesized various metals, such as ruthenium, gold, iridium, platinum, over last 30 years, which aims this review. This review identified 84 quinoline–metal reported across 25 studies, gold (Complex 63) showing significant potency against FcBI strain (IC 50 10 nM), outperforming chloroquine (CQ, indicating coordination enhances drug's action. The ruthenium 03) exhibited activity PFB but less effective than CQ 22.5 vs. 8.2 nM). Other complexes, Au(III) 61), Ir(I) 52), Ir(II) 50), also demonstrated promising results varying effectiveness different strains. Structural features, including linear geometry Au(I) square planar or piano stool geometries Ru(II) Ir play crucial roles influencing their biological activity. These findings highlight potential improving antimalarial efficacy.

Language: Английский

Anticancer Metallocenes and Metal Complexes of Transition Elements from Groups 4 to 7 DOI Creative Commons
Irena Kostova

Molecules, Journal Year: 2024, Volume and Issue: 29(4), P. 824 - 824

Published: Feb. 11, 2024

With the progression in field of bioinorganic chemistry, role transition metal complexes as most widely used therapeutics is becoming a more and attractive research area. The metals possess great variety pharmacological properties, including anticancer, anti-inflammatory, antioxidant, anti-infective, etc., activities. Transition have proven to be potential alternatives biologically active organic compounds, especially antitumor agents. performance coordination compounds living systems anticipated differ generally from action non-metal-containing drugs may offer unique diagnostic and/or therapeutic opportunities. In this review, rapid development application metallocenes elements Groups 4 7 cancer diagnostics therapy been summarized. Most heavy discussed current review are newly discovered metals. That why use their metal-based has attracted lot attention concerning organometallic chemistry. All imposes systematic studies on biological activity, biocompatibility, toxicity presupposes further investigations.

Language: Английский

Citations

4
Pd(ii) complexes bearing NNS pincer ligands: unveiling potent cytotoxicity against breast and pancreatic cancer DOI

Deepika Tanwar,

Tashmeen Kaur,

Athul Sudheendranath

et al.

Dalton Transactions, Journal Year: 2024, Volume and Issue: 53(23), P. 9798 - 9811

Published: Jan. 1, 2024

The continuously increasing rate of breast cancer is one the major threats to female health worldwide.

Language: Английский

Citations

4
Supramolecular Palladium Complexes Based on Guanidinium Pillar[5]arene for Cancer Therapy DOI

Yafei Wen,

Xiaojiao Di,

Zelong Chen

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(87), P. 12694 - 12697

Published: Jan. 1, 2024

A supramolecular palladium complex (G-Pd) is formed through the self-assembly of Pd-complex obtained by coordination guanidinium pillar[5]arene with Pd 2+ , which was used to encapsulate DOX (G-Pd@DOX) for cancer therapy.

Language: Английский

Citations

4
A simple synthetic entryway into (N‐heterocyclic carbene)gold‐steroidyl complexes and their anticancer activity DOI
Thomas Scattolin,

Petra Lippmann,

Marek Beliš

et al.

Applied Organometallic Chemistry, Journal Year: 2022, Volume and Issue: 38(10)

Published: Feb. 1, 2022

A straightforward synthetic route to new N ‐heterocyclic carbene (NHC)‐gold‐steroidyl complexes is reported. The desired were obtained using a weak base (such as K 2 CO 3 ) through concerted‐metallation‐deprotonation (CMD) reaction mechanism occurring between [Au(NHC)Cl] and ethisterone model steroid‐based alkyne. Most displayed good cytotoxicity against panel of cancer cell lines with IC 50 values in the low micromolar range. Cellular uptake most active complex 2a into MCF‐7 breast cells was facilitated by coordinated ligand.

Language: Английский

Citations

18
Advances in the Potential of Quinoline‐Derived Metal Complexes as Antimalarial Agents: A Review DOI Open Access
Carla Peron, Raoni S. B. Gonçalves, Sidnei Moura

et al.

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(3)

Published: Feb. 11, 2025

ABSTRACT Quinolines obtained from native trees of South and Central America, the genus Cinchona , have been used since 17th century for treatment malaria. However, it was only in 1820 that quinine had its structure elucidated, subsequently, during 20th century, several synthetic derivatives were produced with superior activities. In parallel, search synthesis metal complex compounds malaria dates 1994, development ferroquine, an iron derived chloroquine, developed by Biot collaborators at Lille University. After, there are complexes synthesized various metals, such as ruthenium, gold, iridium, platinum, over last 30 years, which aims this review. This review identified 84 quinoline–metal reported across 25 studies, gold (Complex 63) showing significant potency against FcBI strain (IC 50 10 nM), outperforming chloroquine (CQ, indicating coordination enhances drug's action. The ruthenium 03) exhibited activity PFB but less effective than CQ 22.5 vs. 8.2 nM). Other complexes, Au(III) 61), Ir(I) 52), Ir(II) 50), also demonstrated promising results varying effectiveness different strains. Structural features, including linear geometry Au(I) square planar or piano stool geometries Ru(II) Ir play crucial roles influencing their biological activity. These findings highlight potential improving antimalarial efficacy.

Language: Английский

Citations

0