F&S Reports, Journal Year: 2023, Volume and Issue: 5(1), P. 9 - 10
Published: Nov. 30, 2023
Language: Английский
Endocrine Connections, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Anti-Müllerian hormone (AMH), a biomarker secreted by Sertoli cells in the testes, has emerged as critical indicator of male reproductive function with significant clinical application potential. AMH reflects cell activity and plays pivotal role across different stages gonadal function. Firstly, prepubertal males, levels are crucial for assessing testicular development progression puberty, delayed or insufficient secretion often being associated disorders like puberty. Secondly, reproductive-age serves an important evaluating spermatogenic capacity, particularly cases idiopathic non-obstructive azoospermia. In these patients, can help predict success sperm extraction, thereby influencing fertility treatment strategies. This review explores physiological mechanisms its diagnostic prognostic significance both puberty males. While shows great promise management hypogonadism, further research is needed to validate utility refine protocols optimizing patient outcomes.
Language: Английский
Citations
1
Fertility and Sterility, Journal Year: 2024, Volume and Issue: 122(4), P. 636 - 647
Published: June 22, 2024
To explore factors influencing microdissection testicular sperm extraction (micro-TESE) success in hypogonadal men with nonobstructive azoospermia (NOA).
Language: Английский
Citations
5
Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(8), P. 2837 - 2837
Published: April 20, 2025
Purpose: The aim of this study was to investigate the effectiveness and reliability point-of-care ultrasonography (POCUS) in differential diagnosis azoospermia. Materials methods: Records 175 patients who had previously been diagnosed with normal-volume, normal-PH azoospermia undergone surgical sperm retrieval were reviewed retrospectively. Patients’ preoperative evaluations included a comprehensive history physical examination routine scrotal POCUS performed during their initial consultation by non-radiologist treating andrologist clinic setting. Positive imaging revealed ectasia rete testis and/or dilation epididymal ductules. Based on assessments, guided undergo either testicular aspiration (TESA)/microsurgical (MESA) procedures for those suspected obstructive (OA) or microdissection extraction (micro-TESE) non-obstructive (NOA). Results: Of patients, 58 normal follicle-stimulating hormone (FSH) levels (≤12 IU/L) volume. Thirty them no secondary signs obstruction subsequently underwent micro-TESE. All confirmed have NOA. Twenty-eight demonstrated at least two POCUS. these, 15 TESA, 13 MESA procedures. Twenty-seven OA, one as having Among cohort men, sensitivity diagnosing OA 100%, whereas specificity 96.8%. negative predictive values (PPVs NPVs) 96.4 respectively. Conclusions: Scrotal is an effective clinical diagnostic tool distinguishing Being noninvasive, safe, affordable makes it ideal bedside that can serve skilled clinician reliably.
Language: Английский
Citations
0
International braz j urol, Journal Year: 2024, Volume and Issue: 50(3), P. 359 - 365
Published: May 27, 2024
Language: Английский
Citations
3
Andrology, Journal Year: 2024, Volume and Issue: unknown
Published: May 28, 2024
Abstract Background Existing literature does not provide accurate epidemiological data regarding the true prevalence of men with non‐obstructive azoospermia (NOA) who would be eligible for hormonal optimization therapy, according to specific pre‐treatment criteria. Objectives To investigate characteristics those NOA qualify medical therapy prior any SR procedure in a large multi‐centric cross‐sectional study. Materials and methods Complete from 1644 patients seeking help primary infertility at three tertiary referral centers USA, Brazil, Italy were analyzed. Baseline serum hormone levels collected all patients. was confirmed after two consecutive semen analyses. Genetic tests, including karyotype analysis Y microdeletions, performed on Patients secondary hypogonadism (total testosterone (T) less than 300 ng/dL luteinizing (LH) 8 mIU/mL) earmarked as potential candidates receiving clomiphene citrate (CC) and/or human chorionic gonadotropin (hCG). T 17β‐estradiol (E2) ratio < 10 classified aromatase inhibitors (AIs) (e.g., anastrazole). A third sub‐cohort created by combining criteria first sub‐cohorts. Descriptive statistics used detail overall differences between different Results Among 1,644 men, 28% ( n = 460) had LH mIU/mL, thereby being potentially suitable CC hCG, while 37% 607) E2 thus AIs. Lastly, 17.7% 280) met eligibility both hCG Conclusions Findings this multicentric study reveal that about 30% treatment found AIs, 17% therapies. Therefore, these findings show only small subset can benefit considering procedures.
Language: Английский
Citations
3
Andrology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 4, 2025
Abstract Spermatogenesis is primarily controlled by follicle‐stimulating hormone and luteinizing hormone‐driven testosterone. Luteinizing acts on the Leydig cells, stimulating steroid production, predominantly testosterone, activating critical inter‐related spermatogenesis regulatory pathways. Despite evidence that exogenous gonadotropins containing activity, particularly human chorionic gonadotropin, can effectively restore in azoospermic males with hypogonadotropic hypogonadism, use of these drugs to treat other forms non‐obstructive azoospermia subject an ongoing debate. In this review, we delve into molecular properties functions gonadotropin regulation explore available preparations for therapeutic use. We examine regarding effectiveness treating infertility men pre‐testicular or testicular and, additionally, identify main areas future research. Our review highlights role activity emphasizes potential male infertility. The variation characteristics patients underscores importance assessing hormonal profiles when contemplating treatment patients. A novel stratification patients, APHRODITE criteria, which considers clinical laboratory indicators, may assist identifying individuals who could benefit from therapy. While accumulating suggests promising venues pharmacological infertility, including azoospermia, further research required completely elucidate mechanisms underlying effects sperm production establish most effective dosages durations.
Language: Английский
Citations
0
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(16), P. 4939 - 4939
Published: Aug. 21, 2024
Non-obstructive azoospermia (NOA) is found in up to 15% of infertile men. While several causes for NOA have been identified, the exact etiology remains unknown many patients. Advances assisted reproductive technology, including intracytoplasmic sperm injection (ICSI) and testicular retrieval, provided hope these This review summarizes chances success with ICSI patients examines preoperative factors laboratory techniques associated positive outcomes. Furthermore, we reviewed possible consequences offspring by use retrieved from interventions that could potentially mitigate risks. Testicular may exhibit increased chromosomal abnormalities, although lower fertilization pregnancy rates are reported compared other forms infertility, available evidence does not suggest a significant increase miscarriage rate, congenital malformation, or developmental delay their less severe infertility fertile However, due limited data, should receive specialized care personalized management. Counseling essential before initiating any fertility enhancement treatment only health risks but also enhance successful outcomes minimize offspring.
Language: Английский
Citations
2
Asian Journal of Andrology, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 13, 2024
Male infertility has seen an increase in prevalence with cases of azoospermia estimated to affect 10%–15% infertile men. Confirmation subsequently necessitates early causal differentiation between obstructive (OA) and nonobstructive (NOA). Although less common when compared NOA, OA can represent upward 20%–40% azoospermia. While there are a multitude etiologies responsible for causing NOA OA, correctly distinguishing the two types profound implications managing male. This review represents amalgamation current guidelines literature which will supply reproductive physician diagnostic armamentarium properly distinguish therefore providing best possible care couple.
Language: Английский
Citations
1
F&S Reports, Journal Year: 2023, Volume and Issue: 5(1), P. 9 - 10
Published: Nov. 30, 2023
Language: Английский
Citations
0