Exosome encapsulated miRNA let-7d-3p mediated Zearalenone-induced hepatotoxicity with Arid5a/STAT3 signaling pathway DOI

Tongxiao Xu,

Bingxin Huangfu,

Yanan Chen

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 494, P. 138737 - 138737

Published: May 26, 2025

Language: Английский

Rno-miR-130b Attenuates Lipid Accumulation Through Promoting Apoptosis and Inhibiting Differentiation in Rat Intramuscular Adipocytes DOI Open Access

Yichen Yu,

Yongfang Chen, Lijun Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1399 - 1399

Published: Feb. 7, 2025

Our previous studies have shown that miR-130b can significantly inhibit subcutaneous fat deposition in pigs. This study aims to further investigate its effect on lipid accumulation at early-stage (24 and 48 h) late-stage (7 d) adipogenic differentiation clarify potential mechanisms using primary rat intramuscular preadipocytes (IMAs). Results showed 24 h h, overexpression reduced by inhibiting proliferation inducing apoptosis. Furthermore, inhibited the expression of cell cycle apoptosis marker genes. Specifically, mRNA Ccnd1 tended decrease, while BCL2 protein level was decreased h. In contrast, inhibition increased level. At 7 d, mimic intracellular TG content decrease Hsd11b1 promoting Lpl expression. Additionally, CASP3 conclusion, our data indicated for first time could reduce IMAs through different mechanisms: early stage late differentiation, hydrolysis,

Language: Английский

Citations

1
Cattle, swine, poultry and fish cells for meat production: addressing challenges of co-culture and the innovative approaches for muscle and fat integration DOI

Milena Dutra Pierezan,

Silvani Verruck

Current Opinion in Food Science, Journal Year: 2024, Volume and Issue: 60, P. 101230 - 101230

Published: Oct. 22, 2024

Language: Английский

Citations

3
Exosomes: A Promising Drug Delivery Tool in Hepatic Drug Delivery DOI
Neha Kanojia,

Komal Thapa,

Thakur Gurjeet Singh

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106761 - 106761

Published: March 1, 2025

Language: Английский

Citations

0
APOE mediates the coupling of myogenesis and lipid metabolism in skeletal muscle: decoding intercellular crosstalk via a cell co-culture model DOI

Yaping Song,

Jiupan Zhang,

Dongmei Yang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144549 - 144549

Published: May 1, 2025

Language: Английский

Citations

0
Exosome encapsulated miRNA let-7d-3p mediated Zearalenone-induced hepatotoxicity with Arid5a/STAT3 signaling pathway DOI

Tongxiao Xu,

Bingxin Huangfu,

Yanan Chen

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 494, P. 138737 - 138737

Published: May 26, 2025

Language: Английский

Citations

0