Vacunas frente a SARS-CoV-2 y piel DOI Creative Commons
Cristina Galván‐Casas, A. Català, C. Muñoz‐Santos

et al.

Actas Dermo-Sifiliográficas, Journal Year: 2021, Volume and Issue: 112(9), P. 828 - 836

Published: May 27, 2021

Las vacunas contra el SARS-CoV-2 son las primeras que han sido usadas en humanos coronavirus y su desarrollo se ha producido un tiempo récord. En los análisis de seguridad ensayos clínicos previos a aprobación la fase postautorización población, descrito efectos secundarios dermatológicos. La descripción categorización manifestaciones cutáneas COVID-19 fueron importantes para conocimiento enfermedad misma forma pueden serlo generadas por vacunas. este artículo hacemos repaso características diferentes tipos disponibles desarrollo, modo interacción con sistema inmune, consecuentes clínicas generar, especial interés dermatológicos hasta momento descritos, actitudes terapéuticas recomendadas ante cada una estas reacciones. Vaccines against the severe acute respiratory 2, which are first to be used in humans any coronavirus, were developed and produced record time. Dermatologic adverse effects appeared during clinical trials have also been described population since approval. Just as descriptions categorization of skin manifestations disease 2019 proved important for understanding itself, characterizing vaccines may further that goal. This paper reviews properties different types currently available under development describes how they interact with immune system signs cause. We focus on dermatologic reported date recommendations managing them.

Tools and Techniques for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)/COVID-19 Detection DOI
Seyed Hamid Safiabadi Tali, Jason J. LeBlanc,

Zubi Sadiq

et al.

Clinical Microbiology Reviews, Journal Year: 2021, Volume and Issue: 34(3)

Published: May 11, 2021

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory 2 (SARS-CoV-2), has led to millions of confirmed cases and deaths worldwide. Efficient diagnostic tools are in high demand, as rapid large-scale testing plays a pivotal role patient management decelerating spread.

Language: Английский

Citations

347
The Impact of Evolving SARS-CoV-2 Mutations and Variants on COVID-19 Vaccines DOI Creative Commons
Gary R. McLean, Jeremy P. Kamil, Benhur Lee

et al.

mBio, Journal Year: 2022, Volume and Issue: 13(2)

Published: March 30, 2022

The emergence of several new variants severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in recent months has raised concerns around the potential impact on ongoing vaccination programs. Data from clinical trials and real-world evidence suggest that current vaccines remain highly effective against alpha variant (B.1.1.7), while some have reduced efficacy effectiveness symptomatic disease caused by beta (B.1.351) delta (B.1.617.2); however, hospitalization remains high. Although data primary regimen omicron (B.1.1.529) are limited, booster programs using mRNA been shown to restore protection infection (regardless vaccine used for regimen) maintain high hospitalization. However, wanes with time after dose. Studies demonstrated reductions varying magnitude neutralizing activity vaccine-elicited antibodies a range SARS-CoV-2 variants, particular exhibiting partial immune escape. suggests T-cell responses preserved across platforms, regardless concern. Nevertheless, various mitigation strategies under investigation address or future including modification certain (including omicron), multivalent formulations, different delivery mechanisms.

Language: Английский

Citations

178
From delta to Omicron: S1-RBD/S2 mutation/deletion equilibrium in SARS-CoV-2 defined variants DOI
Vasileios Papanikolaou, Aristeidis Chrysovergis, Vasileios Ragos

et al.

Gene, Journal Year: 2022, Volume and Issue: 814, P. 146134 - 146134

Published: Jan. 4, 2022

Language: Английский

Citations

138
Adenoviral Vector-Based Vaccine Platform for COVID-19: Current Status DOI Creative Commons
Vivek P. Chavda, Rajashri Bezbaruah,

Disha Valu

et al.

Vaccines, Journal Year: 2023, Volume and Issue: 11(2), P. 432 - 432

Published: Feb. 13, 2023

The coronavirus disease (COVID-19) breakout had an unimaginable worldwide effect in the 21st century, claiming millions of lives and putting a huge burden on global economy. potential developments vaccine technologies following determination genetic sequence SARS-CoV-2 increasing efforts to bring vaccines therapeutics into market for emergency use have provided small bright spot this tragic event. Several intriguing candidates been developed using recombinant technology, engineering, other development technologies. In last decade, vast amount process has diversified towards usage viral vector-based vaccines. immune response elicited by such is comparatively higher than approved that require booster dose provide sufficient protection. non-replicating adenoviral vectors are promising carriers infectious diseases due better yield, cGMP-friendly manufacturing processes, safety, efficacy, manageable shipping, storage procedures. As April 2022, WHO total 10 around world COVID-19 (33 at least one country), among which three This review sheds light developmental summary all under authorization (EUA) or different stages management.

Language: Английский

Citations

55
From Alpha to Omicron: How Different Variants of Concern of the SARS-Coronavirus-2 Impacted the World DOI Creative Commons

Mickensone Andre,

Lee-Seng Lau,

Marissa D. Pokharel

et al.

Biology, Journal Year: 2023, Volume and Issue: 12(9), P. 1267 - 1267

Published: Sept. 21, 2023

SARS-CoV-2, the virus that causes COVID-19, is prone to mutations and generation of genetic variants. Since its first outbreak in 2019, SARS-CoV-2 has continually evolved, resulting emergence several lineages variants concern (VOC) have gained more efficient transmission, severity, immune evasion properties. The World Health Organization given these names according letters Greek Alphabet, starting with Alpha (B.1.1.7) variant, which emerged 2020, followed by Beta (B.1.351), Gamma (P.1), Delta (B.1.617.2), Omicron (B.1.1.529) This review explores variation among different VOCs how made a global impact on pandemic.

Language: Английский

Citations

55
SARS-CoV-2 Variants: Genetic Insights, Epidemiological Tracking, and Implications for Vaccine Strategies DOI Open Access
Fatimah S. Alhamlan, Ahmed A. Al‐Qahtani

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1263 - 1263

Published: Jan. 31, 2025

The emergence of SARS-CoV-2 variants has significantly impacted the global response to COVID-19 pandemic. This review examines genetic diversity variants, their roles in epidemiological tracking, and influence on viral fitness. Variants concern (VOCs) such as Alpha, Beta, Gamma, Delta, Omicron have demonstrated increased transmissibility, altered pathogenicity, potential resistance neutralizing antibodies. Epidemiological tracking these is crucial for understanding spread, informing public health interventions, guiding vaccine development. also explores how specific mutations spike protein other genomic regions contribute fitness, affecting replication efficiency, immune escape, transmission dynamics. By integrating surveillance data with clinical findings, this provides a comprehensive overview ongoing evolution its implications strategies new

Language: Английский

Citations

2
PD-LAMP smartphone detection of SARS-CoV-2 on chip DOI Creative Commons
Ashlee J. Colbert, Dong Hoon Lee, Katherine N. Clayton

et al.

Analytica Chimica Acta, Journal Year: 2022, Volume and Issue: 1203, P. 339702 - 339702

Published: March 9, 2022

Language: Английский

Citations

46
Emergence of SARS-CoV-2 Variants in the World: How Could This Happen? DOI Creative Commons
Alfredo Parra-Lucares,

Paula Segura,

Verónica Rojas

et al.

Life, Journal Year: 2022, Volume and Issue: 12(2), P. 194 - 194

Published: Jan. 28, 2022

The COVID-19 pandemic has had a significant global impact, with more than 280,000,000 people infected and 5,400,000 deaths. use of personal protective equipment the anti-SARS-CoV-2 vaccination campaigns have reduced infection death rates worldwide. However, recent increase in been observed associated appearance SARS-CoV-2 variants, including recently described lineage B.1.617.2 (Delta variant) B.1.1.529/BA.1 (Omicron variant). These new variants put effectiveness international at risk, outbreaks throughout world. This emergence due to multiple predisposing factors, molecular characteristics virus, geographic environmental conditions, impact social determinants health that favor genetic diversification SARS-CoV-2. We present literature review on most information available analyzed biological, geographical, sociocultural factors development these variants. Finally, we evaluate surveillance strategies for early detection prevent their distribution outside regions.

Language: Английский

Citations

42
SARS-CoV-2: phenotype, genotype, and characterization of different variants DOI Creative Commons
Mohammadreza Saberiyan, Elham Karimi,

Zahra Khademi

et al.

Cellular & Molecular Biology Letters, Journal Year: 2022, Volume and Issue: 27(1)

Published: June 17, 2022

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of disease 2019 (COVID-19), a major international public health concern. Because very similar amino acid sequences seven domain names, SARS-CoV-2 belongs to Coronavirinae subfamily family Coronaviridae, order Nidovirales, and realm Riboviria, placed in exceptional clusters, but categorized as SARS-like species. As RNA virus with longest genome, Coronaviridae genome consists single strand positive (25–32 kb length). Four structural proteins this include spike (S), membrane (M), envelope (E), nucleocapsid (N) protein, all which are encoded within 3′ end genome. By engaging its receptor, angiotensin-converting enzyme (ACE2), infects host cells. According most recent epidemiological data, illness spread globally, several genetic variations appeared quickly, World Health Organization (WHO) naming 11 them. Among these, subtypes have received attention. Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), Delta (B.1.617.2), Omicron (B.1.617.2) now designated concern (VOC) (B.1.1.529). Lambda (C.37) Mu interest (VOI) (B.1.621). The remaining six either being monitored or no longer considered threat. On basis studies done so far, antiviral drugs, antibiotics, glucocorticoids, recombinant intravenous immunoglobulin, plasma therapy, IFN-α2b been used treat patients. Moreover, full vaccination associated lower infection helps prevent transmission, risk cannot be eliminated completely vaccinated people.

Language: Английский

Citations

41
Molecular Evolution of SARS-CoV-2 during the COVID-19 Pandemic DOI Open Access
Luis Daniel González-Vázquez, Miguel Arenas

Genes, Journal Year: 2023, Volume and Issue: 14(2), P. 407 - 407

Published: Feb. 4, 2023

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) produced diverse molecular variants during its recent expansion in humans that caused different transmissibility and severity of the associated disease as well resistance to monoclonal antibodies polyclonal sera, among other treatments. In order understand causes consequences observed SARS-CoV-2 diversity, a variety studies investigated evolution this virus humans. general, evolves with moderate rate evolution, 10

Language: Английский

Citations

29