Effects of Lactobacillus plantarum PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial

Nutrients, Journal Year: 2019, Volume and Issue: 11(4), P. 820 - 820

Published: April 11, 2019

This four-week, randomized, double-blind, placebo-controlled study investigated the effects of Lactobacillus plantarum PS128 (PS128) on boys with autism spectrum disorder (ASD) aged 7-15 in Taiwan. All subjects fulfilled criteria for ASD diagnosis DSM-V and Autism Diagnostic Interview-Revised (ADI-R). Questionnaires used primary outcome measure include Behavior Checklist-Taiwan version (ABC-T), Social Responsiveness Scale (SRS) Child Checklist (CBCL). The Swanson, Nolan, Pelham-IV-Taiwan (SNAP-IV) Clinical Global Impression-improvement (CGI-I) were secondary measure. results showed that ameliorated opposition/defiance behaviors, total score SNAP-IV younger children (aged 712) improved significantly compared placebo group. Additionally, several elements also notably group after 28-day consumption PS128. Further studies are needed to better clarify broader symptoms.

Language: Английский

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Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology

Molecular Autism, Journal Year: 2020, Volume and Issue: 11(1)

Published: Sept. 10, 2020

The complex pathophysiology of autism spectrum disorder encompasses interactions between genetic and environmental factors. On the one hand, hundreds genes, converging at functional level on selective biological domains such as epigenetic regulation synaptic function, have been identified to be either causative or risk factors autism. other exposure chemicals that are widespread in environment, endocrine disruptors, has associated with adverse effects human health, including neurodevelopmental disorders. Interestingly, experimental results suggest an overlap regulatory pathways perturbed by mutations factors, depicting convergences interplays susceptibility toxic insults. pervasive nature chemical poses pivotal challenges for neurotoxicological studies, agencies, policy makers. This highlights emerging need developing new integrative models, biomonitoring, epidemiology, experimental, computational tools, able capture real-life scenarios encompassing interaction chronic mixture substances individuals' backgrounds. In this review, we address intertwined roles lesions Specifically, outline transformative potential stem cell coupled omics analytical approaches increasingly single resolution, tools experimentally dissect pathogenic mechanisms underlying disorders, well improve developmental neurotoxicology assessment.

Language: Английский

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Enhanced removal of the endocrine disruptor compound Bisphenol A by adsorption onto green-carbon materials. Effect of real effluents on the adsorption process

Journal of Environmental Management, Journal Year: 2020, Volume and Issue: 266, P. 110604 - 110604

Published: April 17, 2020

Language: Английский

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Male autism spectrum disorder is linked to brain aromatase disruption by prenatal BPA in multimodal investigations and 10HDA ameliorates the related mouse phenotype

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 7, 2024

Male sex, early life chemical exposure and the brain aromatase enzyme have been implicated in autism spectrum disorder (ASD). In Barwon Infant Study birth cohort (n = 1074), higher prenatal maternal bisphenol A (BPA) levels are associated with ASD symptoms at age 2 diagnosis 9 only males low genetic pathway activity scores. Higher BPA predictive of cord blood methylation across CYP19A1 promoter I.f region (P 0.009) gene mediates 0.01) link between brain-derived neurotrophic factor methylation, independent replication. suppressed expression vitro vivo. mice exposed to mid-gestation or knockout ASD-like behaviors structural functional changes. 10-hydroxy-2-decenoic acid (10HDA), an estrogenic fatty alleviated these features reversed detrimental neurodevelopmental expression. Here we demonstrate that is impaired function ASD-related abnormalities may be reversible through postnatal 10HDA intervention.

Language: Английский

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Sex-specific effects of prenatal bisphenol A exposure on transcriptome-interactome profiles of autism candidate genes in neural stem cells from offspring hippocampus

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 22, 2025

Bisphenol A (BPA), an endocrine-disrupting chemical, is increasingly linked to the pathogenesis of autism spectrum disorder (ASD). This study investigates effects prenatal BPA exposure on neural stem cells (NSCs) from hippocampi rat offspring, a brain region critical for neurodevelopment and implicated in ASD. Pregnant rats were administered with or vehicle control once daily via oral gavage gestational day 1 until parturition. NSCs isolated offspring's postnatal 1, RNA sequencing was performed examine transcriptomic alterations. Differentially expressed genes (DEGs) identified through RNA-seq further analyzed using Ingenuity Pathway Analysis (IPA) explore disrupted pathways. In addition, vitro proliferation assays conducted, utilizing immunofluorescence staining Sox2, cell marker, BrdU quantify proliferating NSCs. Our results revealed that induced sex-specific alterations NSC gene expression, ASD-related such as Atp1a3, Nefl, Grin1 being particularly dysregulated male offspring. Moreover, changes observed. The underscores BPA's potential environmental risk factor ASD, emphasizing need research into its role neurodevelopmental effects.

Language: Английский

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Environmental Chemicals and Autism: A Scoping Review of the Human and Animal Research

Environmental Health Perspectives, Journal Year: 2019, Volume and Issue: 127(4)

Published: April 1, 2019

Background: Estimates of autism prevalence have increased dramatically over the past two decades. Evidence suggests environmental factors may contribute to etiology disorder. Objectives: This scoping review aimed identify and categorize primary research reviews on association between prenatal early postnatal exposure chemicals development in epidemiological studies rodent models autism. Methods: PubMed was searched through 8 February 2018. Included assessed prior 2 months age humans or 14 d rodents. Rodent were considered relevant if they included at least one measurement reciprocal social communicative behavior repetitive stereotyped behavior. Study details are presented interactive displays using Tableau Public. Results: The search returned 21,603 unique studies, which 54 46 experimental 50 deemed relevant, covering 152 chemical exposures. most frequently studied exposures particulate matter (n=14), mercury nonspecific air pollution (n=10), lead (n=10). In chlorpyrifos (n=9), (n=6), (n=4). Discussion: Although is growing rapidly, wide variability exists study design conduct, investigated, outcomes assessed. Conclusions focus recommendations guide best practices epidemiology toxicology, including greater harmonization across these fields more quickly efficiently concern. particular, we recommend chlorpyrifos, lead, polychlorinated biphenyls (PCBs) be systematically reviewed order assess their relationship with There a pressing need move forward understand influences answer current regulatory questions inform treatment prevention efforts. https://doi.org/10.1289/EHP4386

Language: Английский

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Aqueous adsorption of bisphenol A over a porphyrinic porous organic polymer

Chemosphere, Journal Year: 2020, Volume and Issue: 265, P. 129161 - 129161

Published: Dec. 2, 2020

Language: Английский

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Sex Differences in the Effects of Prenatal Bisphenol A Exposure on Genes Associated with Autism Spectrum Disorder in the Hippocampus

Scientific Reports, Journal Year: 2019, Volume and Issue: 9(1)

Published: Feb. 28, 2019

Abstract Autism spectrum disorder (ASD) is a neurodevelopmental inexplicably biased towards males. Although prenatal exposure to bisphenol A (BPA) has recently been associated with the ASD risk, whether BPA dysregulates ASD-related genes in developing brain remains unclear. In this study, transcriptome profiling by RNA-seq analysis of hippocampi isolated from neonatal pups prenatally exposed was conducted and revealed list differentially expressed (DEGs) ASD. Among DEGs, several candidate genes, including Auts2 Foxp2 , were dysregulated showed sex differences response exposure. The interactome pathway analyses DEGs using Ingenuity Pathway Analysis software significant associations between males neurological functions/disorders Moreover, reanalysis data previously published studies consistently that BPA-responsive significantly genes. findings study indicate alters expression ASD-linked hippocampus suggest maternal may increase susceptibility dysregulating functions known be negatively impacted ASD, which deserves further investigations.

Language: Английский

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A comprehensive review of the neurobehavioral effects of bisphenol S and the mechanisms of action: New insights from in vitro and in vivo models

Environment International, Journal Year: 2020, Volume and Issue: 145, P. 106078 - 106078

Published: Sept. 7, 2020

The normal brain development and function are delicately driven by an ever-changing milieu of steroid hormones arising from fetal, placental, maternal origins. This reliance on the neuroendocrine system sets stage for exquisite sensitivity central nervous to adverse effects endocrine‐disrupting chemicals (EDCs). Bisphenol A (BPA) is one most common EDCs which has been a particular focus environmental concern decades due its widespread nature formidable threat human animal health. heightened regulatory actions scientific public over health BPA have led replacement with suite structurally similar but less known alternative chemicals. S (BPS) main substitute that increasingly being used in wide array consumer industrial products. Although it was considered be safe alternative, mounting evidence points deleterious BPS range functions animals. In addition reproductive toxicity, recent experimental efforts indicate considerable potential induce neurotoxicity behavioral dysfunction. review analyzes current state knowledge regarding neurobehavioral discusses mode several aspects system. We summarize role certain their signaling pathways regulation behavior discuss how induces through interactions these pathways. Finally, we links between exposure aberrant animals identify key gaps hypotheses future research.

Language: Английский

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Sex differences in the effects of prenatal bisphenol A exposure on autism-related genes and their relationships with the hippocampus functions

Scientific Reports, Journal Year: 2021, Volume and Issue: 11(1)

Published: Jan. 13, 2021

Abstract Our recent study has shown that prenatal exposure to bisphenol A (BPA) altered the expression of genes associated with autism spectrum disorder (ASD). In this study, we further investigated effects BPA on ASD-related known regulate neuronal viability, neuritogenesis, and learning/memory, assessed these functions in offspring exposed pregnant rats. We found increased neurite length, number primary neurites, branches, but reduced size hippocampal cell body both sexes offspring. However, utero decreased viability density hippocampus impaired learning/memory only male while females were not affected. Interestingly, several (e.g. Mief2 , Eif3h Cux1 Atp8a1 ) dysregulated showed a sex-specific correlation and/or learning/memory. The findings from suggest disrupts involved sex-dependent manner, may play an important role risk higher prevalence ASD males subjected exposure.

Language: Английский

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