Expression of glucocorticoid-receptor covaries with individual differences in visual lateralisation in zebrafish

Animal Cognition, Journal Year: 2025, Volume and Issue: 28(1)

Published: March 13, 2025

Abstract Cerebral lateralisation, the differential cognitive processing in two brain hemispheres, is variable among individuals most vertebrates. Part of this variance has been attributed to plasticity response environmental stressors experienced by and might be therefore mediated action glucocorticoids (GCs). Accordingly, we tested hypothesis that GC pathway related stress, which involved its cognate receptor GR, affects individuals’ lateralisation. First, characterised behavioural lateralisation phenotype outbred wild-type zebrafish using three different tests: a motor test, test involving visual social stimulus (subject’s mirror image), with negative valence (predator). Subsequently, quantified expression gr gene subjects, specifically telencephalon mesencephalon each hemisphere. Our population exhibited individual variation but no population-level bias across hemispheres. When correlated patterns tests expression, observed higher mesencephalic right hemisphere were more inclined process their image Additionally, telencephalon, showed reduced predator stimulus. This study supports GCs affect some aspects particular those stimuli, thought GC-Gr suggests intraspecific could result from differences expression.

Language: Английский

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Modelling the role of glucocorticoid receptor as mediator of endocrine responses to environmental challenge

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2024, Volume and Issue: 379(1898)

Published: Feb. 5, 2024

Glucocorticoid hormones (GCs) modulate acute 'stress' responses in vertebrates, exerting their actions across many physiological systems to help the organism face and overcome challenges. These take place via binding glucocorticoid receptor (GR), which determines not only magnitude of GC-mediated response but also negative feedback that downregulates GCs restore homeostasis. Although GR function is assumed determine GC regulation capacity, associations between abundance individuals' coping abilities remain cryptic. We developed a dynamic model fitted empirical data predict effects on both plasma patterns response. Individuals with higher GRs showed lower exposure, stronger greater capacity adjust this according stressor intensity, may be translated into more resilient flexible phenotypes. Our results show among-individual variability challenges detectability association measurements responses. approach provides mechanistic insights role function, point at fundamentally driving complex features system environmental change. This article part theme issue 'Endocrine variation: conceptual approaches recent developments'.

Language: Английский

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Covariation between glucocorticoid levels and receptor expression modulates embryo development and postnatal phenotypes in gulls

Hormones and Behavior, Journal Year: 2023, Volume and Issue: 149, P. 105316 - 105316

Published: Jan. 31, 2023

The hypothalamic-pituitary-adrenocortical axis can translate, through glucocorticoid secretion, the prenatal environment to development produce phenotypes that match prevailing environmental conditions. However, whether developmental plasticity is modulated by interaction between circulating glucocorticoids and receptor expression remains unclear. Here, we tested covariation plasma corticosterone (CORT) gene (Nr3c1) in blood underlies embryonic programming yellow-legged gulls (Larus michahellis). We examined variations levels of CORT DNA methylation patterns Nr3c1 response two ecologically relevant factors: adult alarm calls (a cue predator presence) changes light competitive disadvantage). then determined postnatal were associated with expression, explored direct indirect relationships environment, hormone-receptor covariation, phenotypes. Prenatal exposure increased up-regulated gull chicks, while cues reduced both hormone expression. Chicks prenatally exposed showed altered profiles regulatory region, but varied throughout breeding season years. Moreover, our results suggest a negative relationship , at least specific CpG sites. interplay affected embryo timing vocalizations, as well hatchling mass fitness-relevant behaviours. These findings provide link inputs, function phenotypic outcomes, suggesting may underlie free-living animals.

Language: Английский

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Corticosterone and glucose are correlated and show similar response patterns to temperature and stress in a free-living bird

Journal of Experimental Biology, Journal Year: 2024, Volume and Issue: 227(14)

Published: July 1, 2024

ABSTRACT Glucocorticoid (GC) hormones have traditionally been interpreted as indicators of stress, but the extent to which they provide information on physiological state remains debated. GCs are metabolic that amongst other functions ensure increasing fuel (i.e. glucose) supply face fluctuating energetic demands, a role often overlooked by ecological studies investigating consequences GC variation. Furthermore, because energy budget is limited, in natural contexts where multiple stimuli coexist, organisms' ability respond physiologically may be constrained when triggers responses overlap time. Using free-living spotless starling (Sturnus unicolor) chicks, we experimentally tested whether two different nature known trigger or response, respectively, cause comparable increase plasma and glucose. We further response patterns differed both occurred consecutively. found experimental treatments caused increases glucose similar magnitude, suggesting variables fluctuate along with variation expenditure, independently trigger. Exposure occurring subsequently did not difference compared exposure single stimulus, limited capacity an additional stimulus during ongoing acute response. Lastly, positive significant correlation between after treatments. Our results add research expenditure variation, providing evidence association metabolism.

Language: Английский

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Gene expression in the female tree swallow brain is associated with inter- and intra-population variation in glucocorticoid levels

Hormones and Behavior, Journal Year: 2022, Volume and Issue: 147, P. 105280 - 105280

Published: Nov. 17, 2022

Language: Английский

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Sumatriptan attenuates fear-learning despair induced by social isolation stress in mice: Mediating role of hypothalamic-pituitary-adrenal axis

Psychoneuroendocrinology, Journal Year: 2024, Volume and Issue: 164, P. 107006 - 107006

Published: Feb. 28, 2024

Language: Английский

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HPA flexibility and FKBP5 : promising physiological targets for conservation

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2024, Volume and Issue: 379(1898)

Published: Feb. 5, 2024

Hypothalamic–pituitary–adrenal axis (HPA) flexibility is an emerging concept recognizing that individuals will cope best with stressors probably be those using their hormones in the most adaptive way. The HPA considers glucocorticoids as molecules convey information about environment from brain to body so organismal phenotype comes complement prevailing conditions. In this context, FKBP5 protein appears set extent which circulating glucocorticoid concentrations can vary within and across stressors. Thus, expression, it causes, seem represent individual's ability regulate its orchestrate responses As expression also easily measured blood, could a worthy target of conservation-oriented research attention. We first review known likely roles wildlife. then describe putative genetic, environmental epigenetic causes variation among individuals. Finally, we hypothesize how should affect fitness hence population viability response human-induced rapid changes, particularly urbanization. This article part theme issue ‘Endocrine variation: conceptual approaches recent developments’.

Language: Английский

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Zebra finches (Taeniopygia castanotis) display varying degrees of stress resilience and recovery in response to constant light

General and Comparative Endocrinology, Journal Year: 2024, Volume and Issue: unknown, P. 114644 - 114644

Published: Nov. 1, 2024

Language: Английский

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From maternal glucocorticoid and thyroid hormones to epigenetic regulation of offspring gene expression: An experimental study in a wild bird species

Evolutionary Applications, Journal Year: 2023, Volume and Issue: 16(10), P. 1753 - 1769

Published: Oct. 1, 2023

Offspring phenotype at birth is determined by its genotype and the prenatal environment including exposure to maternal hormones. Variation in both glucocorticoids thyroid hormones can affect offspring phenotype, but underlying molecular mechanisms, especially those contributing long-lasting effects, remain unclear. Epigenetic changes (such as DNA methylation) have been postulated mediators of effects early-life environment. In this study, we elevated glucocorticoid on handling stress response (breath rate) well methylation gene expression receptor (GR) hormone (THR) great tits (Parus major). Eggs were injected before incubation onset with corticosterone (the main avian glucocorticoid) and/or (thyroxine triiodothyronine) simulate variation deposition. Breath rate during GR THR evaluated 14 days after hatching. Methylation status genes was analyzed from longitudinal blood cells sampled 7 hatching, following autumn. Elevated level significantly increased breath handling, indicating an enhanced metabolic response. Prenatal manipulation had CpG-site-specific putative promoter region, while it did not expression. negatively associated earlier hatching date chick size. or exhibit any significant relationship hormonal treatments examined covariates, suggesting that TH signaling may be more robust due crucial role development. This study provides some support hypothesis influence via epigenetic alterations, yet their possible adaptive optimizing prevailing conditions, context-dependency, interplay needs further research.

Language: Английский

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From maternal glucocorticoid and thyroid hormones to epigenetic regulation of gene expression: an experimental study in a wild bird species

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: March 7, 2023

Offspring phenotype at birth is determined by its genotype and the prenatal environment including exposure to maternal hormones. Variation in both glucocorticoids thyroid hormones can affect offspring phenotype. However, underlying molecular mechanisms shaping phenotype, especially those contributing long-lasting effects, remain unclear. Epigenetic changes (such as DNA methylation) have been postulated mediators of effects early-life environment. In this study, we elevated glucocorticoid on handling stress response (breath rate), methylation gene expression receptor (GCR) hormone (THR) great tit ( Parus major ). Eggs were injected before incubation onset with corticosterone (main avian glucocorticoid) and/or (thyroxine triiodothyronine) simulate variation deposition. Breath rate during GCR THR evaluated 14 days after hatching. Methylation status genes analyzed from longitudinal blood samples taken 7 hatching, well following autumn. Elevated level significantly increased breath handling, indicating enhanced metabolism. Prenatal manipulation had CpG-site-specific putative promoter region, while it did not expression. was negatively associated earlier hatching date chick size. or exhibit any significant relationship hormonal treatments examined covariates, suggesting that TH signaling may be more robust due crucial role development. This study supports view influence metabolism via epigenetic alterations, yet their possible adaptive optimizing prevailing conditions, context-dependency, interplay needs further research.

Language: Английский

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