The Lancet Oncology, Journal Year: 2022, Volume and Issue: 23(10), P. e450 - e458
Published: Sept. 26, 2022
Language: Английский
Nature Reviews Materials, Journal Year: 2021, Volume and Issue: 6(12), P. 1078 - 1094
Published: Aug. 10, 2021
Language: Английский
Citations
2249
Bioengineering & Translational Medicine, Journal Year: 2019, Volume and Issue: 4(3)
Published: Aug. 27, 2019
Nanoparticle drug delivery systems have been used in the clinic since early 1990's. Since that time, field of nanomedicine has evolved alongside growing technological needs to improve various therapeutics. Over these past decades, newer generations nanoparticles emerged are capable performing additional functions can enable treatment via new therapeutic modalities. In current clinical landscape, many generation reached trials and approved for indications. first issue Bioengineering & Translational Medicine 2016, we reviewed history, challenges nanoparticle systems. Here, provide a 3 year update on landscape highlight newly nanomedicines, status previous trials, technologies recently entered clinic.
Language: Английский
Citations
1413
ACS Nano, Journal Year: 2021, Volume and Issue: 15(11), P. 16982 - 17015
Published: June 28, 2021
Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising vehicles to deliver a variety of therapeutics. Currently in spotlight vital components COVID-19 mRNA vaccines, LNPs play key role effectively protecting and transporting cells. Liposomes, an early version LNPs, are versatile nanomedicine delivery platform. A number liposomal drugs been approved applied medical practice. Subsequent generations lipid nanocarriers, such solid nanoparticles, nanostructured carriers, cationic lipid–nucleic acid complexes, exhibit more complex architectures enhanced physical stabilities. With their ability encapsulate therapeutics specific locations within body release contents at desired time, provide valuable platform for treatment diseases. Here, we present landscape LNP-related scientific publications, including patents journal articles, based on analysis CAS Content Collection, largest human-curated collection published knowledge. Rising trends identified, carriers becoming preferred platforms numerous formulations. Recent advancements LNP formulations drug platforms, antitumor nucleic vaccine systems, discussed. Challenges growth opportunities also evaluated other areas, imaging, cosmetics, nutrition, agrochemicals. This report is intended serve useful resource those interested nanotechnologies, applications, global research effort development.
Language: Английский
Citations
1364
Nature Reviews Drug Discovery, Journal Year: 2021, Volume and Issue: 20(11), P. 817 - 838
Published: Aug. 25, 2021
Language: Английский
Citations
1005
Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(18), P. 11385 - 11457
Published: May 3, 2021
Advances in hydrogel technology have unlocked unique and valuable capabilities that are being applied to a diverse set of translational applications. Hydrogels perform functions relevant range biomedical purposes-they can deliver drugs or cells, regenerate hard soft tissues, adhere wet prevent bleeding, provide contrast during imaging, protect tissues organs radiotherapy, improve the biocompatibility medical implants. These make hydrogels useful for many distinct pressing diseases conditions even less conventional areas such as environmental engineering. In this review, we cover major hydrogels, with focus on novel benefits injectable how they relate applications medicine environment. We pay close attention development contemporary requires extensive interdisciplinary collaboration accomplish highly specific complex biological tasks from cancer immunotherapy tissue engineering vaccination. complement our discussion preclinical clinical mechanical design considerations needed scaling technologies application. anticipate readers will gain more complete picture expansive possibilities practical impactful differences across numerous fields
Language: Английский
Citations
735
Molecular Cancer, Journal Year: 2021, Volume and Issue: 20(1)
Published: Feb. 25, 2021
Abstract mRNA vaccines have become a promising platform for cancer immunotherapy. During vaccination, naked or vehicle loaded efficiently express tumor antigens in antigen-presenting cells (APCs), facilitate APC activation and innate/adaptive immune stimulation. vaccine precedes other conventional platforms due to high potency, safe administration, rapid development potentials, cost-effective manufacturing. However, applications been limited by instability, innate immunogenicity, inefficient vivo delivery. Appropriate structure modifications (i.e., codon optimizations, nucleotide modifications, self-amplifying mRNAs, etc.) formulation methods lipid nanoparticles (LNPs), polymers, peptides, investigated overcome these issues. Tuning the administration routes co-delivery of multiple with immunotherapeutic agents (e.g., checkpoint inhibitors) further boosted host anti-tumor immunity increased likelihood cell eradication. With recent U.S. Food Drug Administration (FDA) approvals LNP-loaded prevention COVID-19 therapeutic outcomes achieved several clinical trials against aggressive solid tumors, we envision advancing immunotherapy near future. This review provides detailed overview progress existing challenges future considerations applying immunotherapies.
Language: Английский
Citations
702
Proceedings of the National Academy of Sciences, Journal Year: 2021, Volume and Issue: 118(52)
Published: Dec. 21, 2021
Significance Liver accumulation represents a significant barrier in the development of therapeutically efficacious nanoparticle drug delivery systems. Using series lipid nanoparticles with distinct organ-targeting properties, we provide evidence for plausible mechanism action to non-liver tissues. Following intravenous injection, specific proteins blood are recruited nanoparticle’s surface based on its molecular composition and they endow it unique biological identity that governs ultimate fate body. An innovative paradigm emerges from this mechanistic understanding delivery—endogenous targeting—wherein is rationally engineered interact overcome liver target organs.
Language: Английский
Citations
569
Nature Biotechnology, Journal Year: 2022, Volume and Issue: 40(6), P. 840 - 854
Published: May 9, 2022
Language: Английский
Citations
501
Frontiers in Molecular Biosciences, Journal Year: 2020, Volume and Issue: 7
Published: Oct. 30, 2020
In the golden age of pharmaceutical nanocarriers, we are witnessing a maturation stage original concepts and ideas. There is no doubt that nanoformulations extremely valuable tools for drug delivery applications; current challenge how to optimize them ensure they safe, effective scalable, so can be manufactured at an industrial level advance clinical use. this context, lipid nanoparticles have gained ground, since generally regarded as non-toxic, biocompatible easy-to-produce formulations. Pharmaceutical applications nanocarriers burgeoning field transport diversity therapeutic agents, from biotechnological products small molecules. This review starts with brief overview characteristics solid discusses relevancy performing systematic preformulation studies. The main applications, well advantages type nanovehicles offers in certain scenarios discussed. Next, pharmacokinetic aspects described, such routes administration, absorption after oral distribution organism (including brain penetration) elimination processes. Safety toxicity issues also addressed. Our work presents point view, addressing biopharmaceutical these by means descriptive statistics state-of-the-art research. All presented results, trends, graphs discussions based (and reproducible) bibliographic search considered only papers subject, covering 7 years range (2013-today), period accounts more than 60% total number publications topic databases engines. Focus was placed on fields application, processes efforts translation into practice lipid-based nanoparticles. For this, currently active trials were reviewed, discussion what achievements or milestones still reached, way understanding reasons scarce undergoing trials.
Language: Английский
Citations
490
Vaccines, Journal Year: 2021, Volume and Issue: 9(1), P. 65 - 65
Published: Jan. 19, 2021
The recent success of mRNA vaccines in SARS-CoV-2 clinical trials is part due to the development lipid nanoparticle delivery systems that not only efficiently express mRNA-encoded immunogen after intramuscular injection, but also play roles as adjuvants and vaccine reactogenicity. We present an overview then focus on nanoparticles used current trials. review concludes with analysis determinants performance vaccines.
Language: Английский
Citations
461