Lipid Nanoparticles─From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement

ACS Nano, Journal Year: 2021, Volume and Issue: 15(11), P. 16982 - 17015

Published: June 28, 2021

Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising vehicles to deliver a variety of therapeutics. Currently in spotlight vital components COVID-19 mRNA vaccines, LNPs play key role effectively protecting and transporting cells. Liposomes, an early version LNPs, are versatile nanomedicine delivery platform. A number liposomal drugs been approved applied medical practice. Subsequent generations lipid nanocarriers, such solid nanoparticles, nanostructured carriers, cationic lipid–nucleic acid complexes, exhibit more complex architectures enhanced physical stabilities. With their ability encapsulate therapeutics specific locations within body release contents at desired time, provide valuable platform for treatment diseases. Here, we present landscape LNP-related scientific publications, including patents journal articles, based on analysis CAS Content Collection, largest human-curated collection published knowledge. Rising trends identified, carriers becoming preferred platforms numerous formulations. Recent advancements LNP formulations drug platforms, antitumor nucleic vaccine systems, discussed. Challenges growth opportunities also evaluated other areas, imaging, cosmetics, nutrition, agrochemicals. This report is intended serve useful resource those interested nanotechnologies, applications, global research effort development.

Language: Английский

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Controlled Drug Delivery Systems: Current Status and Future Directions

Molecules, Journal Year: 2021, Volume and Issue: 26(19), P. 5905 - 5905

Published: Sept. 29, 2021

The drug delivery system enables the release of active pharmaceutical ingredient to achieve a desired therapeutic response. Conventional systems (tablets, capsules, syrups, ointments, etc.) suffer from poor bioavailability and fluctuations in plasma level are unable sustained release. Without an efficient mechanism, whole process can be rendered useless. Moreover, has delivered at specified controlled rate target site as precisely possible maximum efficacy safety. Controlled developed combat problems associated with conventional delivery. There been tremendous evolution past two decades ranging macro scale nano intelligent targeted initial part this review provides basic understanding emphasis on pharmacokinetics drug. It also discusses their limitations. Further, discussed detail design considerations, classifications drawings. In addition, nano-drug delivery, smart using stimuli-responsive biomaterials is recent key findings. paper concludes challenges faced future directions

Language: Английский

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Lipid Nanoparticles for Drug Delivery

Advanced NanoBiomed Research, Journal Year: 2021, Volume and Issue: 2(2)

Published: Nov. 25, 2021

Lipid nanoparticles have attracted significant interests in the last two decades, and achieved tremendous clinical success since first approval of Doxil 1995. At same time, lipid also demonstrated enormous potential delivering nucleic acid drugs as evidenced by RNA therapies mRNA COVID‐19 vaccines. In this review, an overview on different classes nanoparticles, including liposomes, solid nanostructured carriers, is provided, followed introduction their preparation methods. Then characterizations are briefly reviewed applications encapsulating hydrophobic drugs, hydrophilic RNAs highlighted. Finally, various for overcoming delivery challenges, crossing blood–brain barrier, targeted delivery, routes administration, summarized. drug systems offer many attractive benefits such great biocompatibility, ease preparation, feasibility scale‐up, nontoxicity, while current challenges warrant future studies about structure–function correlations, large‐scale production, to realize full wider pharmaceutical future.

Language: Английский

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Lipid Nanoparticles as Carriers for Bioactive Delivery

Frontiers in Chemistry, Journal Year: 2021, Volume and Issue: 9

Published: April 23, 2021

Nanotechnology has made a great impact on the pharmaceutical, biotechnology, food, and cosmetics industries. More than 40% of approved drugs are lipophilic have poor solubility. This is major rate-limiting step that influences release profile bioavailability drugs. Several approaches been reported to administer with improved solubility bioavailability. plays crucial role in targeted delivery poorly soluble Nanotechnology-based drug systems can be classified as solid lipid nanoparticulate systems, emulsion-based nanodrug vesicular etc. presents new frontier research development conquer limitations coupled conventional through formation specific functionalized particles. review bird's eye view various aspects nanoparticles carriers bioactive molecules is, synthesis, characterization, advantage, disadvantage, toxicity, application medical field. Update recent terms patents clinical trials (SLNs) nanostructure (NLCs) also discussed this article.

Language: Английский

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Lipid-Based Nanoparticles for Drug/Gene Delivery: An Overview of the Production Techniques and Difficulties Encountered in Their Industrial Development

ACS Materials Au, Journal Year: 2023, Volume and Issue: 3(6), P. 600 - 619

Published: Aug. 21, 2023

Over the past decade, therapeutic potential of nanomaterials as novel drug delivery systems complementing conventional pharmacology has been widely acknowledged. Among these nanomaterials, lipid-based nanoparticles (LNPs) have shown remarkable pharmacological performance and promising outcomes, thus gaining substantial interest in preclinical clinical research. In this review, we introduce main types LNPs used formulations such liposomes, nanoemulsions, solid lipid nanoparticles, nanostructured carriers, polymer hybrid focusing on their physicochemical properties potential. We discuss computational studies modeling techniques to enhance understanding how interact with cargo predict effectiveness interactions applications. also analyze benefits drawbacks various LNP production nanoprecipitation, emulsification, evaporation, thin film hydration, microfluidic-based methods, an impingement jet mixer. Additionally, major challenges associated industrial development, including stability sterilization, storage, regulatory compliance, reproducibility, quality control. Overcoming facilitating compliance represent key steps toward LNP's successful commercialization translation into settings.

Language: Английский

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On a highway to the brain: A review on nose-to-brain drug delivery using nanoparticles

Applied Materials Today, Journal Year: 2022, Volume and Issue: 29, P. 101631 - 101631

Published: Sept. 5, 2022

Language: Английский

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Where Is Nano Today and Where Is It Headed? A Review of Nanomedicine and the Dilemma of Nanotoxicology

ACS Nano, Journal Year: 2022, Volume and Issue: 16(7), P. 9994 - 10041

Published: June 22, 2022

Worldwide nanotechnology development and application have fueled many scientific advances, but technophilic expectations technophobic demands must be counterbalanced in parallel. Some of the burning issues today are following: (1) Where is nano today? (2) How good communication investment networks between academia/research governments? (3) Is there any spotlight for nanotechnology? Nanomedicine a particular arm within healthcare landscape, focused on diagnosis, treatment, monitoring emerging (such as coronavirus disease 2019, COVID-19) contemporary (including diabetes, cardiovascular diseases, neurodegenerative disorders, cancer) diseases. However, it may only represent bright side coin. In fact, recent past, concept nanotoxicology has emerged to address dark shadows nanomedicine. The nanomedicine field requires more nanotoxicological studies identify undesirable effects guarantee safety. Here, we provide an overall perspective central pieces giant puzzle nanotechnology. First, impact education research highlighted, followed by market trends output tendencies. next section, dilemma addressed through interplay silico, vitro, vivo models with support omics microfluidic approaches. Lastly, reflection regulatory clinical trials provided. Finally, some conclusions future perspectives proposed clearer safer translation nanomedicines from bench bedside.

Language: Английский

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Lipid nanoparticles for delivery of RNA therapeutics: Current status and the role of in vivo imaging

Theranostics, Journal Year: 2022, Volume and Issue: 12(17), P. 7509 - 7531

Published: Jan. 1, 2022

Lipid nanoparticles (LNPs) have been one of the most successful nano-delivery vehicles that enable efficient delivery cytotoxic chemotherapy agents, antibiotics, and nucleic acid therapeutics.During coronavirus disease (COVID-19) pandemic, LNP-based COVID-19 messenger RNA (mRNA) vaccines from Pfizer/BioNTech Moderna successfully developed, resulting in global sales $37 billion $17.7 billion, respectively, 2021.Based on this success, development multiple therapeutics is gaining momentum due to its potential for various genetic diseases cancers.Furthermore, imaging techniques can be utilized evaluate pharmacokinetics pharmacodynamics (PK/PD) effects, which helps target discovery accelerates mRNA therapies.A thorough introduction explanation components LNPs functions along with production methods formulating are provided review.Furthermore, recent advances clinics clinical trials explored.Additionally, evaluation PK/PD current roles developing pharmaceutics through will discussed.

Language: Английский

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Nanomaterials in tumor immunotherapy: new strategies and challenges

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: June 13, 2023

Abstract Tumor immunotherapy exerts its anti-tumor effects by stimulating and enhancing immune responses of the body. It has become another important modality therapy with significant clinical efficacy advantages compared to chemotherapy, radiotherapy targeted therapy. Although various kinds tumor immunotherapeutic drugs have emerged, challenges faced in delivery these drugs, such as poor permeability low cell uptake rate, had prevented their widespread application. Recently, nanomaterials emerged a means for treatment different diseases due targeting properties, biocompatibility functionalities. Moreover, possess characteristics that overcome defects traditional immunotherapy, large drug loading capacity, precise easy modification, thus leading wide application immunotherapy. There are two main classes novel nanoparticles mentioned this review: organic (polymeric nanomaterials, liposomes lipid nanoparticles) inorganic (non-metallic metallic nanomaterials). Besides, fabrication method nanoparticles, Nanoemulsions, was also introduced. In summary, review article mainly discussed research progress based on past few years offers theoretical basis exploring strategies future.

Language: Английский

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Recent advances in nanotechnology for eradicating bacterial biofilm

Theranostics, Journal Year: 2022, Volume and Issue: 12(5), P. 2383 - 2405

Published: Jan. 1, 2022

Microorganisms grouped together into spatially-organized communities called biofilms, are the cause of dramatic chronic infections in plants, animals and humans. In this review, characteristics biofilms their interactions with antimicrobials first described. Limitations antibiotic treatments discussed, state-of-the-art alternative approaches based on use polymer, lipid, organic, inorganic hybrid nanoparticles presented, highlighting recent achievements application nanomaterials to field theranostics for eradication biofilm. The aim review is present a complete vision nanobiotechnology-based eradicating bacterial fighting antimicrobial tolerance.

Language: Английский

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