Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(13), P. 5365 - 5451
Published: Jan. 1, 2022
The
present
review
details
a
chronological
description
of
the
events
that
took
place
during
development
mesoporous
materials,
their
different
synthetic
routes
and
use
as
drug
delivery
systems.
outstanding
textural
properties
these
materials
quickly
inspired
translation
to
nanoscale
dimension
leading
silica
nanoparticles
(MSNs).
aspects
introducing
pharmaceutical
agents
into
pores
nanocarriers,
together
with
possible
biodistribution
clearance
routes,
would
be
described
here.
smart
nanocarriers
are
able
release
high
local
concentration
therapeutic
cargo
on-demand
after
application
certain
stimuli
reviewed
here,
ability
deliver
precise
locations
in
body.
huge
progress
design
MSNs
for
biomedical
applications,
including
potential
treatment
diseases,
last
20
years
will
collated
required
work
still
needs
done
achieve
clinical
materials.
This
was
conceived
stand
out
from
past
reports
since
it
aims
tell
story
systems
by
some
makers,
who
could
considered
among
pioneers
this
area.
Nanoparticle
drug
delivery
systems
have
been
used
in
the
clinic
since
early
1990's.
Since
that
time,
field
of
nanomedicine
has
evolved
alongside
growing
technological
needs
to
improve
various
therapeutics.
Over
these
past
decades,
newer
generations
nanoparticles
emerged
are
capable
performing
additional
functions
can
enable
treatment
via
new
therapeutic
modalities.
In
current
clinical
landscape,
many
generation
reached
trials
and
approved
for
indications.
first
issue
Bioengineering
&
Translational
Medicine
2016,
we
reviewed
history,
challenges
nanoparticle
systems.
Here,
provide
a
3
year
update
on
landscape
highlight
newly
nanomedicines,
status
previous
trials,
technologies
recently
entered
clinic.
Molecules,
Journal Year:
2020,
Volume and Issue:
25(9), P. 2193 - 2193
Published: May 8, 2020
Nanotechnology
offers
many
advantages
in
various
fields
of
science.
In
this
regard,
nanoparticles
are
the
essential
building
blocks
nanotechnology.
Recent
advances
nanotechnology
have
proven
that
acquire
a
great
potential
medical
applications.
Formation
stable
interactions
with
ligands,
variability
size
and
shape,
high
carrier
capacity,
convenience
binding
both
hydrophilic
hydrophobic
substances
make
favorable
platforms
for
target-specific
controlled
delivery
micro-
macromolecules
disease
therapy.
Nanoparticles
combined
therapeutic
agents
overcome
problems
associated
conventional
therapy;
however,
some
issues
like
side
effects
toxicity
still
debated
should
be
well
concerned
before
their
utilization
biological
systems.
It
is
therefore
important
to
understand
specific
properties
strategies.
Here,
we
provide
an
overview
on
unique
features
We
emphasize
type
clinically
used
specificity
applications,
as
current
strategies
diseases
such
cancer,
infectious,
autoimmune,
cardiovascular,
neurodegenerative,
ocular,
pulmonary
diseases.
Understanding
characteristics
environment
will
enable
us
establish
novel
treatment,
prevention,
diagnosis
diseases,
particularly
untreatable
ones.
Theranostics,
Journal Year:
2020,
Volume and Issue:
10(17), P. 7921 - 7924
Published: Jan. 1, 2020
Following
its
discovery
more
than
30
years
ago,
the
enhanced
permeability
and
retention
(EPR)
effect
has
become
guiding
principle
for
cancer
nanomedicine
development.
Over
years,
tumor-targeted
drug
delivery
field
made
significant
progress,
as
evidenced
by
approval
of
several
nanomedicinal
anticancer
drugs.
Recently,
however,
existence
extent
EPR
-
particularly
in
patients
have
focus
intense
debate.
This
is
partially
due
to
disbalance
between
huge
number
preclinical
papers
relatively
small
products
reaching
market.
To
move
forward,
we
improve
our
understanding
effect,
type-specific
pathophysiology,
interactions
with
heterogeneous
tumor
microenvironment,
behavior
body,
translational
aspects
that
specifically
complicate
In
this
virtual
special
issue,
24
research
articles
reviews
discussing
different
are
collected,
together
providing
a
comprehensive
complete
overview
current
state-of-the-art
future
directions
delivery.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: May 25, 2023
Abstract
Blood–brain
barrier
(BBB)
is
a
natural
protective
membrane
that
prevents
central
nervous
system
(CNS)
from
toxins
and
pathogens
in
blood.
However,
the
presence
of
BBB
complicates
pharmacotherapy
for
CNS
disorders
as
most
chemical
drugs
biopharmaceuticals
have
been
impeded
to
enter
brain.
Insufficient
drug
delivery
into
brain
leads
low
therapeutic
efficacy
well
aggravated
side
effects
due
accumulation
other
organs
tissues.
Recent
breakthrough
materials
science
nanotechnology
provides
library
advanced
with
customized
structure
property
serving
powerful
toolkit
targeted
delivery.
In-depth
research
field
anatomical
pathological
study
on
further
facilitates
development
brain-targeted
strategies
enhanced
crossing.
In
this
review,
physiological
different
cells
contributing
are
summarized.
Various
emerging
permeability
regulation
crossing
including
passive
transcytosis,
intranasal
administration,
ligands
conjugation,
coating,
stimuli-triggered
disruption,
overcome
obstacle
highlighted.
Versatile
systems
ranging
organic,
inorganic,
biologics-derived
their
synthesis
procedures
unique
physio-chemical
properties
summarized
analyzed.
This
review
aims
provide
an
up-to-date
comprehensive
guideline
researchers
diverse
fields,
offering
perspectives
system.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(2), P. 661 - 661
Published: Jan. 9, 2023
Nanotechnology,
contrary
to
its
name,
has
massively
revolutionized
industries
around
the
world.
This
paper
predominantly
deals
with
data
regarding
applications
of
nanotechnology
in
modernization
several
industries.
A
comprehensive
research
strategy
is
adopted
incorporate
latest
driven
from
major
science
platforms.
Resultantly,
a
broad-spectrum
overview
presented
which
comprises
diverse
modern
study
reveals
that
not
limited
labs
or
small-scale
manufacturing
units
nanomedicine,
but
instead
taken
share
different
Companies
world
are
now
trying
make
their
innovations
more
efficient
terms
structuring,
working,
and
designing
outlook
productivity
by
taking
advantage
nanotechnology.
From
processing
such
as
those
agriculture,
food,
medicine
larger-scale
production
operating
automobiles,
civil
engineering,
environmental
management,
manifested
almost
every
industrial
domain
on
global
scale.
With
pronounced
cooperation
among
researchers,
industrialists,
scientists,
technologists,
environmentalists,
educationists,
sustainable
development
nano-based
can
be
predicted
future.
Cancer Nanotechnology,
Journal Year:
2019,
Volume and Issue:
10(1)
Published: Dec. 1, 2019
Abstract
Background
In
recent
years,
disease
treatment
has
evolved
strategies
that
require
increase
in
pharmaceutical
agent’s
efficacy
and
selectivity
while
decreasing
their
toxicity
normal
tissues.
These
requirements
have
led
to
the
development
of
nanoscale
liposome
systems
for
drug
release.
This
review
focuses
on
lipid
features,
pharmacological
properties
liposomal
formulations
clinical
studies
application.
Main
body
Several
lipids
are
available,
but
could
affect
or
efficiency
formulations.
Many
been
developed
currently
market.
Proper
selection
is
essential
effect
be
improved.
Most
use
mainly
zwitterionic,
cationic
anionic
lipids,
PEG
and/or
cholesterol,
which
different
effects
stability,
pharmacokinetics
delivery
formulation.
Clinical
trials
shown
liposomes
pharmacologically
pharmacokinetically
more
efficient
than
drug-alone
treating
acute
myeloid
leukemia,
hepatitis
A,
pain
management,
ovary,
gastric
breast
lung
cancer,
among
others.
Conclusion
Liposomal
less
toxic
drugs
alone
better
parameters.
Although
they
seem
first
choice
various
diseases,
further
research
about
dosage
regimen
regarding
dose
time
needs
carried
out.
