Dopamine System Dysregulation in Major Depressive Disorders

The International Journal of Neuropsychopharmacology, Journal Year: 2017, Volume and Issue: 20(12), P. 1036 - 1046

Published: June 28, 2017

Anhedonia is considered a core feature of major depressive disorder, and the dopamine system plays pivotal role in hedonic deficits described this disorder. Dopaminergic activity complex under regulation multiple brain structures, including ventral subiculum hippocampus basolateral amygdala. Whereas basic clinical studies demonstrate dopaminergic depression, origin these likely lies dysregulation its regulatory afferent circuits. This review explores current information regarding modulation relevance to as well some system-level effects novel antidepressants such agomelatine ketamine.

Language: Английский

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Chronic unpredictable mild stress for modeling depression in rodents: Meta-analysis of model reliability

Neuroscience & Biobehavioral Reviews, Journal Year: 2018, Volume and Issue: 99, P. 101 - 116

Published: Dec. 6, 2018

Language: Английский

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Neuroscience of apathy and anhedonia: a transdiagnostic approach

Nature reviews. Neuroscience, Journal Year: 2018, Volume and Issue: 19(8), P. 470 - 484

Published: June 26, 2018

Language: Английский

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Prefrontal cortex and depression

Neuropsychopharmacology, Journal Year: 2021, Volume and Issue: 47(1), P. 225 - 246

Published: Aug. 2, 2021

Language: Английский

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Animal models of major depression: drawbacks and challenges

Journal of Neural Transmission, Journal Year: 2019, Volume and Issue: 126(11), P. 1383 - 1408

Published: Oct. 4, 2019

Major depression is a leading contributor to the global burden of disease. This situation mainly related chronicity and/or recurrence disorder, and poor response antidepressant therapy. Progress in this area requires valid animal models. Current models are based either on manipulating environment which rodents exposed (during developmental period or adulthood) biological underpinnings (i.e. gene deletion overexpression candidate genes, targeted lesions brain areas, optogenetic control specific neuronal populations, etc.). These manipulations can alter behavioural outcomes that be different symptomatic pathophysiological dimensions major depression. However, display substantial shortcomings contribute lack innovative pharmacological approaches recent decades hamper our capabilities investigate treatment-resistant Here, we discuss validity these models, review putative depression, subtypes recurrent Furthermore, identify future challenges regarding new paradigms such as those proposing dimensional rather than categorical

Language: Английский

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Sex differences in depression: Insights from clinical and preclinical studies

Progress in Neurobiology, Journal Year: 2019, Volume and Issue: 176, P. 86 - 102

Published: Feb. 2, 2019

Language: Английский

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Sex differences in the hypothalamic–pituitary–adrenal axis’ response to stress: an important role for gonadal hormones

Neuropsychopharmacology, Journal Year: 2018, Volume and Issue: 44(1), P. 45 - 58

Published: Aug. 1, 2018

Language: Английский

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Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice

Proceedings of the National Academy of Sciences, Journal Year: 2021, Volume and Issue: 118(17)

Published: April 13, 2021

Depression is a widespread and devastating mental illness the search for rapid-acting antidepressants remains critical. There now exciting evidence that psychedelic compound psilocybin produces not only powerful alterations of consciousness, but also rapid persistent antidepressant effects. How exerts its therapeutic actions known, it widely presumed these require altered which known to be dependent on serotonin 2A receptor (5-HT2AR) activation. This hypothesis has never been tested, however. We therefore asked whether would exert antidepressant-like responses in mice and, if so, required 5-HT2AR Using chronically stressed male mice, we observed single injection reversed anhedonic assessed with sucrose preference female urine tests. The antianhedonic response was accompanied by strengthening excitatory synapses hippocampus-a characteristic traditional fast-acting antidepressants. Neither behavioral nor electrophysiological were prevented pretreatment 5-HT2A/2C antagonist ketanserin, despite positive ketanserin's efficacy. conclude psilocybin's mechanism action can studied animal models suggest perception may further 5-HT2AR-independent restoration synaptic strength cortico-mesolimbic reward circuits contribute action. possibility combining compounds offers potential means increase their acceptance clinical utility should human depression.

Language: Английский

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Behavioral methods to study anxiety in rodents

Dialogues in Clinical Neuroscience, Journal Year: 2017, Volume and Issue: 19(2), P. 181 - 191

Published: June 30, 2017

Stress is a precipitating factor for anxiety-related disorders, which are among the leading forms of psychiatric illness and impairment in modern world. Rodent-based behavioral tests models widely used to understand mechanisms by stress triggers behaviors identify new treatments disorders. Although substantial progress has been made many key neural circuits molecular pathways mediating responsiveness have characterized, these advances thus far failed translate into fundamentally that safer more efficacious humans. The purpose this article describe methods historically type research highlight approaches align with recent conceptualizations disease symptomatology may ultimately prove be fruitful facilitating development improved therapeutics.

Language: Английский

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The future of rodent models in depression research

Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 20(11), P. 686 - 701

Published: Oct. 2, 2019

Language: Английский

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