Sleep quality and anxiety levels among university students DOI Creative Commons
Dalaine Nogueira Silva, Adne Oliveira Lima, Lorruan Alves dos Santos

et al.

O Mundo da Saúde, Journal Year: 2022, Volume and Issue: 46, P. 247 - 254

Published: Jan. 1, 2022

The present article seeks to describe the quality of sleep and excessive daytime sleepiness university students verify levels trait anxiety (A-Trait) state (A-State) presented by them. A sample, composed undergraduate from courses, responded an online form, containing following questionnaires: Sociodemographic; Epworth Sleepiness Scale; Pittsburgh Sleep Quality Index; State-Trait Anxiety Inventory. descriptive analysis data was then performed. mean age 305 participants 22 ± 2.99 years, 51.37% were female, 98.03% non-smokers, 52.8% consumed alcohol, 54.1% practiced physical activity. majority demonstrated absence (62.3%), poor (72.4%), moderate A-Trait (56.4%) A-State (47.2%). main findings this study reveal that volunteers have with a level state-trait anxiety. results also indicate profile who answered questionnaire young adults did not employment relationship single. There among students. In addition, scores at levels.

Language: Английский

Microglia, Lifestyle Stress, and Neurodegeneration DOI Creative Commons
Charlotte Madore, Zhuoran Yin, Jeffrey Leibowitz

et al.

Immunity, Journal Year: 2020, Volume and Issue: 52(2), P. 222 - 240

Published: Jan. 7, 2020

Language: Английский

Citations

250
The Links Between the Gut Microbiome, Aging, Modern Lifestyle and Alzheimer's Disease DOI Creative Commons
Sholpan Askarova, Bauyrzhan Umbayev, Abdul‐Razak Masoud

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2020, Volume and Issue: 10

Published: March 18, 2020

Gut microbiome is a community of microorganisms in the gastrointestinal tract. These bacteria have tremendous impact on human physiology healthy individuals and during an illness. Intestinal can influence one's health either directly by secreting biologically active substances such as vitamins, essential amino acids, lipids et cetera or indirectly modulating metabolic processes immune system. In recent years considerable information has been accumulated relationship between gut brain functions. Moreover, significant quantitative qualitative changes reported patients with Alzheimer's disease (AD). On other hand, highly sensitive to negative external lifestyle aspects, diet, sleep deprivation, circadian rhythm disturbance, chronic noise, sedentary behavior, which are also considered important risk factors for development sporadic AD. this regard, review focused analyzing links microbiome, modern lifestyle, aging disease.

Language: Английский

Citations

177
Sleep, circadian rhythms and health DOI Open Access
F. Foster

Interface Focus, Journal Year: 2020, Volume and Issue: 10(3), P. 20190098 - 20190098

Published: April 17, 2020

At the core of human thought, for majority individuals in developed nations at least, there is tacit assumption that as a species we are unfettered by demands imposed our biology and can do what want, whatever time choose, whereas reality every aspect physiology behaviour constrained 24 h beat arising from deep within evolution. Our daily circadian rhythms sleep/wake cycle allow us to function optimally dynamic world, adjusting day/night cycle. The themes this review focus upon growing realization ignore sleep systems peril, paper considers mechanisms generate regulate systems; happens mechanistically when these collapse result societal pressures disease; how disruption stress linked; why mental illness invariably occur together; employers attempt mitigate some problems associated with working against internal temporal biology. While health costs be reduced, short-term will always significant negative consequences shift work loss. With mind, society needs address issue decide justified workplace.

Language: Английский

Citations

173
Gamma Oscillations in Alzheimer’s Disease and Their Potential Therapeutic Role DOI
Artemis Traikapi, Nikos Konstantinou

Frontiers in Systems Neuroscience, Journal Year: 2021, Volume and Issue: 15

Published: Dec. 13, 2021

Despite decades of research, Alzheimer’s Disease (AD) remains a lethal neurodegenerative disorder for which there are no effective treatments. This review examines the latest evidence novel and newly introduced perspective, focuses on restoration gamma oscillations investigates their potential role in treatment AD. Gamma brain activity (∼25–100 Hz) has been well-known its cognitive function, including memory, it is fundamental healthy intra-brain communication. Aberrant have observed both mice AD models human patients. A recent line work demonstrated that entrainment, through auditory visual sensory stimulation, can effectively attenuate pathology improve function disease. The first from patients indicate entrainment therapy reduce loss functional connectivity atrophy, ameliorate several pathological markers Even though research still infancy, suggests gamma-based may disease-modifying effect signified new promising era research.

Language: Английский

Citations

72
Gut Microbiota is an Impact Factor based on the Brain-Gut Axis to Alzheimer’s Disease: A Systematic Review DOI Creative Commons
Bin Zou, Jia Li, Ruixia Ma

et al.

Aging and Disease, Journal Year: 2023, Volume and Issue: 14(3), P. 964 - 964

Published: Jan. 1, 2023

Alzheimer's disease (AD) is a degenerative of the central nervous system. The pathogenesis AD has been explained using cholinergic, β-amyloid toxicity, tau protein hyperphosphorylation, and oxidative stress theories. However, an effective treatment method not developed. In recent years, with discovery brain-gut axis (BGA) breakthroughs made in Parkinson's disease, depression, autism, other diseases, BGA become hotspot research. Several studies have shown that gut microbiota can affect brain behavior patients AD, especially their cognitive function. Animal models, fecal transplantation, probiotic intervention also provide evidence regarding correlation between AD. This article discusses relationship related mechanisms based on to possible strategies for preventing or alleviating symptoms by regulating microbiota.

Language: Английский

Citations

40
Benzodiazepines and Related Drugs as a Risk Factor in Alzheimer's Disease Dementia DOI Creative Commons
Miren Ettcheto, Jordi Olloquequi, Elena Sánchez‐López

et al.

Frontiers in Aging Neuroscience, Journal Year: 2020, Volume and Issue: 11

Published: Jan. 8, 2020

Benzodiazepines (BZDs) and Z-drugs are compounds widely prescribed in medical practice due to their anxiolytic, hypnotic muscle relaxant properties. Yet, chronic use is associated with cases of abuse, dependence relapse many patients. Furthermore, elderly people susceptible alterations pharmacodynamics, pharmacokinetics, as well drug interaction polypharmacy. These situations increase the risk for appearance cognitive affectations development pathologies like Alzheimer’s disease (AD). In present work there a summary some clinical studies that have evaluated effect BZDs adult population without AD, focusing on relationship between loss function. Additionally, an assessment preclinical focused finding molecular proof pathways by which these drugs could be involved AD pathogenesis. Moreover, available data (1990-2019) use, among patients, was compiled this work. Finally, BZD treatment insomnia biomarkers analysed. Results pointed vicious circle would worsen condition patients over time. Likewise, it put into relevance need close monitorization those using also suffer from AD. Consequently, future should focus optimizing strategies other substances melatonin agonists, described much more significant safety profile.

Language: Английский

Citations

57
Paeoniflorin exerts antidepressant-like effects through enhancing neuronal FGF-2 by microglial inactivation DOI
Jie Cheng, Min Chen,

Huiqi Wan

et al.

Journal of Ethnopharmacology, Journal Year: 2021, Volume and Issue: 274, P. 114046 - 114046

Published: March 20, 2021

Language: Английский

Citations

48
An update on the use of gamma (multi)sensory stimulation for Alzheimer’s disease treatment DOI Creative Commons
Valerio Manippa, Annalisa Palmisano, Marco Filardi

et al.

Frontiers in Aging Neuroscience, Journal Year: 2022, Volume and Issue: 14

Published: Dec. 15, 2022

Alzheimer's disease (AD) is characterized by reduced fast brain oscillations in the gamma band (γ, > 30 Hz). Several animal studies show that inducing through (multi)sensory stimulation at 40 Hz has potential to impact AD-related cognitive decline and neuropathological processes, including amyloid plaques deposition, neurofibrillary tangles formation, neuronal synaptic loss. Therefore Gamma Entrainment Using Sensory (GENUS) among most promising approaches for AD patients' treatment. This review summarizes evidence on GENUS effectiveness, from models patients. Despite application human its infancy, available findings suggest feasibility treatment of AD. We discuss such results light parameter improvement possible underlying mechanisms. finally emphasize need further research development as a disease-modifying non-pharmacological intervention.

Language: Английский

Citations

31
Prevalence of sleep-related breathing disorders and associated risk factors among people with dementia: A meta-analysis DOI
Nur Aini, Hsin Chu, Kondwani Joseph Banda

et al.

Sleep Medicine, Journal Year: 2023, Volume and Issue: 103, P. 51 - 61

Published: Jan. 30, 2023

Language: Английский

Citations

18
The Critical Role of Nurr1 as a Mediator and Therapeutic Target in Alzheimer’s Disease-related Pathogenesis DOI Creative Commons
Seong Gak Jeon,

Anji Yoo,

Dong Wook Chun

et al.

Aging and Disease, Journal Year: 2020, Volume and Issue: 11(3), P. 705 - 705

Published: Jan. 1, 2020

Several studies have revealed that the transcription factor nuclear receptor related 1 (Nurr1) plays several roles not only in regulation of gene expression to dopamine synthesis, but also alternative splicing, and miRNA targeting.Moreover, it regulates cognitive functions protects against inflammationinduced neuronal death.In particular, role Nurr1 pathogenesis Parkinson's disease (PD) has been well investigated; for example, shown restores behavioral histological impairments PD models.Although many evaluated connection between pathogenesis, Alzheimer's (AD) remain be studied.There describing protein AD brain.However, a few examined context AD.Therefore, this review, we highlight overall effects under neuropathologic conditions AD.Furthermore, suggest possibility using as therapeutic target or other neurodegenerative disorders.

Language: Английский

Citations

40