Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression

Journal of Neuroinflammation, Journal Year: 2022, Volume and Issue: 19(1)

Published: June 6, 2022

Abstract Major depressive disorder is a highly debilitating psychiatric involving the dysfunction of different cell types in brain. Microglia are predominant resident immune cells brain and exhibit critical role depression. Recent studies have suggested that depression can be regarded as microglial disease. regulate inflammation, synaptic plasticity, formation neural networks, all which affect In this review, we highlighted microglia pathology First, described activation animal models clinically depressed patients. Second, emphasized possible mechanisms by recognize depression-associated stress conditions. Third, how antidepressants (clinical medicines natural products) activation. Thus, review aimed to objectively analyze focus on potential antidepressants. These data regulation actions might novel therapeutic strategy counteract adverse effects devastating mental disorders.

Language: Английский

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Anti-Inflammatory, Antioxidant, and Neuroprotective Effects of Polyphenols—Polyphenols as an Element of Diet Therapy in Depressive Disorders

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2258 - 2258

Published: Jan. 23, 2023

Depressive disorders can affect up to 350 million people worldwide, and in developed countries, the percentage of patients with depressive may be as high 10%. During depression, activation pro-inflammatory pathways, mitochondrial dysfunction, increased markers oxidative stress, a reduction antioxidant effectiveness body are observed. It is estimated that approximately 30% depressed do not respond traditional pharmacological treatments. However, more attention being paid influence active ingredients food on course risk neurological disorders, including depression. The possibility using foods containing polyphenols an element diet therapy depression was analyzed review. whether consumption products such could alleviate or prevent progression it also considered. Results from preclinical studies demonstrate potential phenolic compounds have reduce behaviors by regulating factors related neuroinflammation, modulation intestinal microbiota.

Language: Английский

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Genus Paeonia monoterpene glycosides: A systematic review on their pharmacological activities and molecular mechanisms

Phytomedicine, Journal Year: 2024, Volume and Issue: 127, P. 155483 - 155483

Published: Feb. 28, 2024

Language: Английский

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Paeoniflorin: A neuroprotective monoterpenoid glycoside with promising anti-depressive properties

Phytomedicine, Journal Year: 2021, Volume and Issue: 90, P. 153669 - 153669

Published: July 22, 2021

Language: Английский

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The multifaceted mechanisms of Paeoniflorin in the treatment of tumors: State-of-the-Art

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 149, P. 112800 - 112800

Published: March 9, 2022

Paeoniflorin is a water-soluble monoterpenoid glycoside that can be derived from multiple herbaceous plants, such as Radix Paeoniae Rubra, Alba, Paeonia suffruticosa and Cimicifugae Foetidae. Multiple studies have suggested possesses an excellent anti-tumor effect in variety of tumors, including liver cancer, gastric breast lung pancreatic colorectal cancer bladder cancer. It induce cell apoptosis, inhibit proliferation, invasion metastasis via different molecular mechanisms, which are mainly involved nuclear transcription factor kappα (NF-κB), B-cell lymphoma-2(Bcl-2) family, MicroRNA, neural precursor expressed developmentally down-regulated protein 4(NEDD4) signaling pathway, activating (STAT3), p21, p53/14-3-3 transforming growth factor-β1(TGF-β1)/Smads Mitogen-activated kinase (MAPK) pathway Notch-1. Current on mechanism action remain unclear. Therefore, this study reviews the research progress attempt to provide new thought theoretical basis for further development clinical application Paeoniflorin.

Language: Английский

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The macrophage polarization in inflammatory dermatosis and its potential drug candidates

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 161, P. 114469 - 114469

Published: March 2, 2023

Inflammatory dermatosis is characterized by persistent inflammatory infiltration and hard repair of diseased skin. As a member the human innate immune cells, macrophages usually show different phenotypes in diseases. The macrophage phenotype (M1/M2) imbalance caused increase M1 or decrease M2 common dermatosis. In recent years, with deepening research on skin diseases, more natural medicines/traditional Chinese medicines (TCMs), represented Shikonin Angelica Dahurica, have shown their therapeutic effects affecting polarization macrophages. This review introduced dermatosis, such as psoriasis. Then summarized medicines/TCMs that potential so far mechanisms action proteins/signal pathways involved. We found TCMs listed this are closely related to theory five flavors four properties medicinal, most them bitter, acrid sweet. Bitter antipyretic, anti-inflammatory antibacterial effects, which may improve inflammation infiltration. Acrid effect promoting blood circulation, while sweet nourishing. These 2 accelerate lesions conclusion, we hope provide sufficient knowledge for medicine development imbalance.

Language: Английский

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Modified Xiaoyao San reverses lipopolysaccharide-induced depression-like behavior through suppressing microglia M1 polarization via enhancing autophagy involved in PI3K/Akt/mTOR pathway in mice

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 315, P. 116659 - 116659

Published: May 30, 2023

Language: Английский

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NLRP3 Inflammasome: From Pathophysiology to Therapeutic Target in Major Depressive Disorder

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 24(1), P. 133 - 133

Published: Dec. 21, 2022

Major depressive disorder (MDD) is a highly prevalent psychiatric disorder, whose pathophysiology has been linked to the neuroinflammatory process. The increased activity of Nod-like receptor pyrin containing protein 3 (NLRP3) inflammasome, an intracellular multiprotein complex, intrinsically implicated in neuroinflammation by promoting maturation and release proinflammatory cytokines such as interleukin (IL)-1β IL-18. Interestingly, individuals suffering from MDD have higher expression NLRP3 inflammasome components when compared healthy individuals. In part, intense activation may be related autophagic impairment. Noteworthy, some conventional antidepressants induce autophagy, resulting less inflammasome. addition, fast-acting antidepressant ketamine, bioactive compounds physical exercise also shown anti-inflammatory properties via inhibition. Therefore, it suggested that modulation inflammasome-driven pathways effect. Here, we review role pathogenesis MDD, highlighting its priming are potential therapeutic targets for treatment MDD.

Language: Английский

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Antidepressant effects of the traditional Chinese herbal formula Xiao-Yao-San and its bioactive ingredients

Phytomedicine, Journal Year: 2022, Volume and Issue: 109, P. 154558 - 154558

Published: Nov. 21, 2022

Language: Английский

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Mechanisms of paeoniaceae action as an antidepressant

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 13

Published: Feb. 8, 2023

Paeoniflorin (PF) has been widely used for the treatment of depression in mice models, some Chinese herbal compound containing PF on treating depression, such as Xiaoyao San, Chaihu-Shugan-San, Danggui Shaoyao San etc. Many experiments are also verifying whether these powders can be an effective component depression. Therefore, this review antidepressant effect and its mechanism action outlined with particular focus following aspects: increasing levels monoamine neurotransmitters, inhibiting HPA axis, promoting neuroprotection, enhancing neurogenesis hippocampus, elevating brain-derived neurotrophic factor (BDNF). This may helpful application

Language: Английский

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