Journal of Neurology, Journal Year: 2005, Volume and Issue: 253(1), P. 38 - 44
Published: July 13, 2005
Language: Английский
The Lancet Neurology, Journal Year: 2013, Volume and Issue: 13(1), P. 83 - 99
Published: Dec. 9, 2013
Language: Английский
Citations
527
Cell, Journal Year: 2015, Volume and Issue: 162(6), P. 1338 - 1352
Published: Sept. 1, 2015
Language: Английский
Citations
289
CNS Drugs, Journal Year: 2017, Volume and Issue: 31(3), P. 217 - 236
Published: Feb. 9, 2017
Due to the heterogeneous nature of disease, it is a challenge capture disease activity multiple sclerosis (MS) in reliable and valid way. Therefore, can be difficult assess true efficacy interventions clinical trials. In phase III trials MS, traditionally used primary outcome measures are Expanded Disability Status Scale relapse rate. Secondary these number or volume T2 hyperintense lesions gadolinium-enhancing T1 on magnetic resonance imaging (MRI) brain. These secondary often II MS. Despite several limitations, traditional still mainstay for assessing treatment efficacy. Newer potentially valuable increasingly explored MS are, clinically, Functional Composite patient-reported measures, MRI, brain atrophy formation persisting black holes. Several limitations have been addressed further improvements will probably proposed. Major coverage additional functional domains such as cognitive functioning assessment ability carry out activities daily living. The development multidimensional promising because potential cover full extent progression. this review, we provide an overview historical background recent developments We discuss advantages various including newer assessments optical coherence tomography, biomarkers body fluids concept 'no evidence activity'.
Language: Английский
Citations
173
Journal of Autoimmunity, Journal Year: 2017, Volume and Issue: 82, P. 13 - 30
Published: June 16, 2017
Language: Английский
Citations
155
Neuroepidemiology, Journal Year: 2015, Volume and Issue: 44(4), P. 199 - 214
Published: Jan. 1, 2015
Relapses (episodic exacerbations of neurological signs or symptoms) are a defining feature relapsing-remitting multiple sclerosis (MS), the most prevalent MS phenotype. While their diagnostic value relates predominantly to definition clinically definite MS, prognostic is determined by relatively high associated risk incomplete remission resulting in residual disability. The mechanisms governing relapse incidence unknown, but numerous modifiers have been described, including demographic and clinical characteristics, many which represent opportunities for improved disease management. Also phenotypes with patient characteristics an individual predisposition certain phenotypic presentations may imply neuroanatomical patterns. immunomodulatory therapies corticosteroids mainstay prevention acute management, respectively, effect has only partial further search more efficient warranted. Other areas research include pathophysiology determinants incidence, recurrence phenotypes, relapsing non-relapsing variants responsiveness therapies.
Language: Английский
Citations
150
Eye, Journal Year: 2011, Volume and Issue: 25(7), P. 833 - 842
Published: April 29, 2011
Language: Английский
Citations
131
Arthritis Research & Therapy, Journal Year: 2019, Volume and Issue: 21(1)
Published: Aug. 30, 2019
We aimed to investigate the effects of ambient respiratory viral infections in general population on rheumatoid arthritis (RA) development.Data weekly incident RA (2012-2013) were obtained from Korean National Health Insurance claims database, and those observations eight Korea Centers for Disease Control Prevention database. estimated percentage change associated with mean using a generalized linear model, after adjusting time trend, air pollution, meteorological data.A total 24,117 cases (mean age 54.7 years, 18,688 [77.5%] women) analyzed. Ambient higher number over time, its effect peaked 6 or 7 weeks exposure. Among 8 viruses, parainfluenza virus (4.8% 1% infection increase, 95% CI 1.6 8.1, P = .003), coronavirus (9.2%, 3.9 14.8, < .001), metapneumovirus (44%, 2.0 103.4, .038) increased RA. The impact these remained significant women (3.8%, 12.1%, 67.4%, respectively, .05) older patients (10.7%, 14.6%, 118.2%, .05).Ambient an RA, especially patients, suggesting that can be novel environmental risk factor development
Language: Английский
Citations
125
NeuroToxicology, Journal Year: 2016, Volume and Issue: 61, P. 189 - 212
Published: April 3, 2016
Language: Английский
Citations
112
Frontiers in Immunology, Journal Year: 2015, Volume and Issue: 6
Published: Oct. 19, 2015
Over the past several decades, significant advances have been made in identifying key factors that contribute to pathogenesis of multiple sclerosis (MS) and culminated approval some effective therapeutic strategies for disease intervention. However, mechanisms by which environmental factors, such as infection, and/or symptom exacerbation remain be fully elucidated. Relapse frequency MS patients contributes neurological impairment and, initial phases disease, serves a predictor poor prognosis. The purpose this review is examine evidence supports role peripheral infection modulating natural history disease. Evidence supporting promoting animal models also reviewed. Finally, few may exacerbate symptoms other diseases are discussed. Those who comprise majority acquire approximately two upper-respiratory infections per year; furthermore, type doubles risk relapse, underscoring contribution relationship being potentially important particularly detrimental.
Language: Английский
Citations
110
Inflammopharmacology, Journal Year: 2022, Volume and Issue: 30(5), P. 1569 - 1596
Published: June 5, 2022
Language: Английский
Citations
57