Mitochondria-Targeted Antioxidants, an Innovative Class of Antioxidant Compounds for Neurodegenerative Diseases: Perspectives and Limitations

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3739 - 3739

Published: Feb. 13, 2023

Neurodegenerative diseases comprise a wide spectrum of pathologies characterized by progressive loss neuronal functions and structures. Despite having different genetic backgrounds etiology, in recent years, many studies have highlighted point convergence the mechanisms leading to neurodegeneration: mitochondrial dysfunction oxidative stress been observed pathologies, their detrimental effects on neurons contribute exacerbation pathological phenotype at various degrees. In this context, increasing relevance has acquired antioxidant therapies, with purpose restoring order revert damage. However, conventional antioxidants were not able specifically accumulate diseased mitochondria, often eliciting harmful whole body. last decades, novel, precise, mitochondria-targeted (MTA) compounds developed studied, both vitro vivo, address need counter mitochondria restore energy supply membrane potentials neurons. review, we focus activity therapeutic perspectives MitoQ, SkQ1, MitoVitE MitoTEMPO, most studied belonging class MTA conjugated lipophilic cations, reach compartment.

Language: Английский

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New Insights into the Role of Oxidative Stress Mechanisms in the Pathophysiology and Treatment of Multiple Sclerosis

Oxidative Medicine and Cellular Longevity, Journal Year: 2016, Volume and Issue: 2016(1)

Published: Jan. 1, 2016

Multiple sclerosis (MS) is a multifactorial disease of the central nervous system (CNS) characterized by an inflammatory process and demyelination. The etiology still not fully understood. Therefore, finding new etiological factors such crucial importance. It suspected that development MS may be affected oxidative stress (OS). In acute phase OS initiates processes in chronic it sustains neurodegeneration. Redox are associated with mitochondrial dysfunction, dysregulation axonal bioenergetics, iron accumulation brain, impaired oxidant/antioxidant balance, memory. present paper review current literature about role focuses on all major aspects. article explains mechanisms OS, reports unique biomarkers regard to their clinical significance, presents poorly understood relationship between also provides novel methods treatment, including use antioxidants neuroprotection. Furthermore, adding drugs treatment relapse useful. considers significance patients.

Language: Английский

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Impact of B cells to the pathophysiology of multiple sclerosis

Journal of Neuroinflammation, Journal Year: 2019, Volume and Issue: 16(1)

Published: June 25, 2019

Multiple sclerosis (MS) is a chronic autoimmune disorder that affects the central nervous system and compromises health well-being of millions people worldwide. B cells have been linked to MS its progression. This review aimed determine role in development. Articles used this were obtained from PubMed, LILACS, EBSCO. The search terms phrases included "multiple sclerosis," "MS," "B-Cells," "pathogenesis," "development." Original research studies articles on published between 2007 2018 included. Results selected showed significant connection cell groups MS. act as source plasma cells, which generate antibodies while also regulating processes T production. In addition, regulate release molecules affect proinflammatory actions other immune cells. play key roles functioning findings illustrate complex nature actions, their effects system, method by they contribute pathogenesis. Previous implicates biological, genetic, environmental factors suggests development advancement influencing such production APC activity.

Language: Английский

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Protection of Fecal Microbiota Transplantation in a Mouse Model of Multiple Sclerosis

Mediators of Inflammation, Journal Year: 2020, Volume and Issue: 2020, P. 1 - 13

Published: Aug. 5, 2020

Given the growing evidence of a link between gut microbiota (GM) dysbiosis and multiple sclerosis (MS), fecal transplantation (FMT), aimed at rebuilding GM, has been proposed as new therapeutic approach to MS treatment. To evaluate viability FMT for treatment its impact on pathology, we tested in mice with experimental autoimmune encephalomyelitis (EAE), mouse model MS. We provide that can rectify altered GM some extent effect EAE. also found led reduced activation microglia astrocytes conferred protection blood-brain barrier (BBB), myelin, axons Taken together, our data suggest FMT, GM-based therapy, potential be an effective

Language: Английский

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Prevalence of depression and anxiety in the different clinical forms of multiple sclerosis and associations with disability: A systematic review and meta-analysis

Brain Behavior & Immunity - Health, Journal Year: 2022, Volume and Issue: 24, P. 100484 - 100484

Published: July 6, 2022

Multiple sclerosis (MS) is a chronic neurodegenerative and autoimmune disease. Motor, sensory cognitive deficits in MS are commonly accompanied by psychiatric disorders. Depression anxiety affect the quality of life patients, treatment still not well-established. Prevalence rates patients for depression vary widely between studies. However, prevalence these disorders subgroups their association with disability has been studied yet. Therefore, this systematic review meta-analysis proposes to estimate perform subgroup analyses (study type, Extended Disability Status Scale/EDSS, duration MS, region, type MS) on observational The protocol was registered PROSPERO (4202125033). A computerized search PubMed, EMBASE Scopus studies performed from 2015 2021, 12 articles were included. Most had low risk bias. 27.01% (MS), 15.78% (relapsing-remitting multiple sclerosis/RRMS), 19.13% (progressive sclerosis/PMS). For 35.19% 21.40% (RRMS), 24.07% (PMS). depression/anxiety EDSS <3 26.69/45.56% >3 22.96/26.70%. Using HADS-A (8) 38.5% 22.4%. Then, our study brought together current data regarding which comorbidities that patients.

Language: Английский

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Data quality evaluation for observational multiple sclerosis registries

Multiple Sclerosis Journal, Journal Year: 2016, Volume and Issue: 23(5), P. 647 - 655

Published: Aug. 1, 2016

Objective: Objective and reproducible evaluation of data quality is paramount importance for studies ‘real-world’ observational data. Here, we summarise a standardised quality, density generalisability process implemented by MSBase, global multiple sclerosis (MS) cohort study. Methods: Error rate, score were developed using all 35,869 patients enrolled in MSBase as November 2015. The was calculated across six domains (follow-up, demography, visits, MS relapses, paraclinical therapy) emphasised completeness. error rate evaluated syntactic accuracy consistency believability the demographic treatment information. Correlations among three scores number per centre evaluated. Results: Errors identified at median 3 100 patient-years. indicated samples’ representativeness known epidemiology. Moderate correlation between (ρ = 0.58) weak other two −0.32 to −0.33) observed. strongly correlated with size 0.79). Conclusion: enable objective data, an impact on design future analyses.

Language: Английский

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Dendritic cells in brain diseases

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2015, Volume and Issue: 1862(3), P. 352 - 367

Published: Nov. 11, 2015

Language: Английский

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Ozone, NO2 and PM10 are associated with the occurrence of multiple sclerosis relapses. Evidence from seasonal multi-pollutant analyses

Environmental Research, Journal Year: 2018, Volume and Issue: 163, P. 43 - 52

Published: Feb. 7, 2018

Language: Английский

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Does the Gut Microbiota Influence Immunity and Inflammation in Multiple Sclerosis Pathophysiology?

Journal of Immunology Research, Journal Year: 2017, Volume and Issue: 2017, P. 1 - 14

Published: Jan. 1, 2017

Aim. Evaluation of the impact gut microflora on pathophysiology MS. Results . The etiopathogenesis MS is not fully known. Gut microbiota may be a great importance in pathogenesis MS, since recent findings suggest that substitutions certain microbial population can lead to proinflammatory state, which humans. In contrast, other commensal bacteria and their antigenic products protect against inflammation within central nervous system. type intestinal flora affected by antibiotics, stress, or diet. effects through also achieved antibiotic therapy Lactobacillus EAE, as an animal model indicates strong influence immune system shows disturbances physiology contribute development Conclusions. relationship between system, relates microorganisms A possible interaction perceived regulation endocannabinoid It offer opportunity understand comprised gut-immune-brain axis.

Language: Английский

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Update on the management of multiple sclerosis during the COVID-19 pandemic and post pandemic: An international consensus statement

Journal of Neuroimmunology, Journal Year: 2021, Volume and Issue: 357, P. 577627 - 577627

Published: June 7, 2021

In this consensus statement, we provide updated recommendations on multiple sclerosis (MS) management during the COVID-19 crisis and post-pandemic period applicable to neurology services around world. Statements/recommendations were generated based available literature experience of 13 MS expert panelists using a modified Delphi approach online. The statements/recommendations give advice regarding implementation telemedicine; use disease-modifying therapies relapses; people with at highest risk from COVID-19; radiological monitoring; remote pharmacovigilance; impact research; implications for lowest income settings, other key issues.

Language: Английский

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