Molecular Aspects of Medicine,
Journal Year:
2024,
Volume and Issue:
97, P. 101275 - 101275
Published: May 20, 2024
Diagnostic
tests
were
heralded
as
crucial
during
the
Coronavirus
disease
(COVID-19)
pandemic
with
most
of
key
methods
using
bioanalytical
approaches
that
detected
larger
molecules
(RNA,
protein
antigens
or
antibodies)
rather
than
conventional
clinical
biochemical
techniques.
Nucleic
Acid
Amplification
Tests
(NAATs),
like
Polymerase
Chain
Reaction
(PCR),
and
other
molecular
methods,
sequencing
(that
often
work
in
combination
NAATs),
essential
to
diagnosis
management
COVID-19.
This
was
exemplified
both
early
but
also
later
on,
following
emergence
new
genetic
SARS-CoV-2
variants.
The
100
day
mission
respond
future
threats
highlights
need
for
effective
diagnostics,
therapeutics
vaccines.
Of
three,
diagnostics
represents
first
opportunity
manage
infectious
diseases
while
being
poorly
supported
terms
infrastructure
needed
demonstrate
effectiveness.
Where
performance
targets
exist,
they
are
not
well
served
by
consensus
on
how
met;
this
includes
analytical
factors
such
limit
detection
(LOD)
false
positive
results
approach
evaluation.
selection
gold
standards
use
epidemiological
predictive
value,
reference
ranges
thresholds
seldom
correctly
considered.
attention
placed
diagnostic
COVID-19
illustrates
important
considerations
assumptions
these
beyond.
In
manuscript,
we
discuss
state-of-the-art
evaluation
explore
may
be
better
tailored
techniques
NAATs
maximise
impact
highly
versatile
tools,
generally
outbreaks.
International Medical Science Research Journal,
Journal Year:
2023,
Volume and Issue:
3(1), P. 1 - 23
Published: Oct. 16, 2023
This
comprehensive
review
elucidates
the
evolution
of
laboratory
diagnostics
in
Nigeria's
response
to
COVID-19,
emphasizing
its
pivotal
role
managing
infectious
diseases.
The
purpose
this
is
analyze
advancements
diagnostic
approaches
and
their
implications
on
effective
pandemic
management
future
preparedness.
A
robust
research
strategy
was
employed,
involving
a
systematic
synthesis
critical
peer-reviewed
articles,
focusing
innovations,
developments,
challenges
procedures
during
pandemic.
results
revealed
significant
progress
methodologies
technologies,
with
enhanced
capabilities
detect
control
spread
diseases,
despite
logistical,
infrastructural,
regulatory
challenges.
concluded
that
have
multifaceted
impacts
shaping
strategies
altering
public
health
policy
practice.
Recommendations
include
strengthening
capacities,
developing
sustainable
strategies,
investing
development,
promoting
international
collaboration,
enhancing
systems.
insights
derived
are
instrumental
envisioning
evolving
driving
transformative
changes
healthcare
delivery,
ensuring
more
approach
disease
management.
Keywords:
Laboratory
Diagnostics,
Infectious
Diseases,
Pandemic
Management,
Diagnostic
Advancements,
Public
Health
Policy,
Healthcare
Systems.
Clinical Infectious Diseases,
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 5, 2024
Abstract
The
critical
nature
of
the
microbiology
laboratory
in
infectious
disease
diagnosis
calls
for
a
close,
positive
working
relationship
between
physician
and
microbiologists
who
provide
enormous
value
to
healthcare
team.
This
document,
developed
by
experts
both
adult
pediatric
clinical
medicine,
provides
information
on
which
tests
are
valuable
contexts,
that
add
little
or
no
diagnostic
decisions.
Sections
divided
into
anatomic
systems,
including
Bloodstream
Infections
Cardiovascular
System,
Central
Nervous
System
Infections,
Ocular
Soft
Tissue
Head
Neck,
Upper
Respiratory
Lower
Tract
Gastrointestinal
Tract,
Intraabdominal
Bone
Joint
Urinary
Genital
Skin
Infections;
etiologic
agent
groups,
arboviral
Viral
Syndromes,
Blood
Parasite
Infections.
Each
section
contains
introductory
concepts,
summary
key
points,
detailed
tables
list
suspected
agents;
most
reliable
order;
samples
(and
volumes)
collect
order
preference;
specimen
transport
devices,
procedures,
times,
temperatures;
notes
specific
issues
regarding
test
methods,
such
as
when
likely
require
specialized
have
prolonged
turnaround
times.
In
addition,
needs
management
also
addressed.
There
is
redundancy
among
sections,
many
agents
assay
choices
overlap.
document
intended
serve
reference
guide
physicians
choosing
will
aid
them
diagnose
diseases
their
patients.
The Lancet Microbe,
Journal Year:
2023,
Volume and Issue:
4(8), P. e632 - e641
Published: July 14, 2023
Elucidating
viral
dynamics
within
the
host
is
important
for
designing
public
health
measures
against
SARS-CoV-2,
particularly
during
early
stages
of
infection
when
transmission
potential
rapidly
increases.
We
aimed
to
analyse
and
antibody
omicron
variant
in
relation
symptom
onset
or
laboratory
confirmation
replication
throughout
course.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(27)
Published: Jan. 23, 2024
The
improvement
of
living
standards
and
the
advancement
medical
technology
have
led
to
an
increased
focus
on
health
among
individuals.
Detections
biomarkers
are
feasible
approaches
obtaining
information
about
status,
disease
progression,
response
treatment
individual.
In
recent
years,
organic
electrochemical
transistors
(OECTs)
demonstrated
high
electrical
performances
effectiveness
in
detecting
various
types
biomarkers.
This
review
provides
overview
working
principles
OECTs
their
performance
multiple
biomarkers,
with
a
advances
representative
applications
wearable
implantable
biomarker
detections,
perspective
for
future
development
OECT-based
sensors.
