Determinants of COVID-19 vaccination status and hesitancy among older adults in China

Nature Medicine, Journal Year: 2023, Volume and Issue: 29(3), P. 623 - 631

Published: Jan. 31, 2023

Language: Английский

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Extracellular vesicles in COVID-19 prognosis, treatment, and vaccination: an update

Applied Microbiology and Biotechnology, Journal Year: 2023, Volume and Issue: 107(7-8), P. 2131 - 2141

Published: March 14, 2023

Abstract The lethality of the COVID 19 pandemic became trigger for one most meteoric races on record in search strategies disease control. Those include development rapid and sensitive diagnostic methods, therapies to treat severe cases, anti-SARS-CoV-2 vaccines, latter responsible current relative control disease. However, commercially available vaccines are still far from conferring protection against acquiring infection, so more efficient that can cut transmission variants concerns currently predominate those will emerge is a prevailing need. On other hand, considering here stay, new diagnosis treatment also desirable. In this sense, there has recently been great interest taking advantage benefits offered by extracellular vesicles (EVs), membrane structures nanoscale size carry information between cells participating manner many physiological homeostatic pathological processes. focused fact EVs relatively easy obtain manipulate, allowing design natural nanocarriers deliver molecules interest, as well about pathogens, which be exploited aforementioned purposes. Studies have shown infection with SARS-CoV-2 induces release different sources, including platelets, their increase blood, some markers, could used prognosis severity. Likewise, sources being ideal carriers delivering active drugs disease, vaccine antigens. review, we describe progress made these three years regarding use diagnosis, treatment, vaccination infection. Key points • Covid-19 requires effective specific treatments vaccines. emerging an option multiple advantages. Association engineered its presented.

Language: Английский

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Impact of baseline and trajectory of the atherogenic index of plasma on incident diabetic kidney disease and retinopathy in participants with type 2 diabetes: a longitudinal cohort study

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Jan. 11, 2024

Some studies have assessed the predictive role of atherogenic index plasma (AIP) for macrovascular diseases. This prospective investigation aimed to elucidate whether AIP is associated with diabetic kidney disease (DKD) and retinopathy (DR) incidence.

Language: Английский

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Impact of the COVID-19 Pandemic on Attitudes toward Vaccination: Representative Study of Polish Society

Vaccines, Journal Year: 2023, Volume and Issue: 11(6), P. 1069 - 1069

Published: June 6, 2023

The study explored the association between individuals' attitudes toward vaccination and their actual behavior. We also examined impact of coronavirus disease 2019 (COVID-19) pandemic ongoing debate on changing towards vaccination, specifically within different demographic groups. survey was conducted among a representative sample Poles (N = 805) using computer-assisted web interview (CAWI) technology. As demonstrated, those who identified themselves as strong vaccine supporters were statistically significantly more frequently to be vaccinated with COVID-19 booster doses, follow physician's recommendation any without hesitation, strengthened in confidence vaccines during (p < 0.001 for all). However, over half responders declared moderate supporters/opponents, groups whose further are likely affected by (mis)communication. Importantly, than that weakened pandemic, while 43% not against COVID-19. In addition, demonstrated older better-educated individuals COVID-19-vaccinated p 0.013, respectively). results this imply that, order improve acceptance, it is essential strengthen public health communication avoid errors pandemic.

Language: Английский

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Perceived benefits, information, vaccination history, and conspiracy beliefs as significant determinants of RSV vaccine acceptance among Arab seniors

Therapeutic Advances in Vaccines and Immunotherapy, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 1, 2025

Background: Respiratory syncytial virus (RSV) poses a significant respiratory health risk to senior citizens, contributing substantially hospitalizations and mortality. With the recent approval of three RSV vaccines for elderly, it is critical understand factors that can shape vaccination attitudes inform public strategies enhance uptake among this vulnerable population. Objectives: This study aimed investigate potential could influence toward citizens in Arab countries. Design: A multinational cross-sectional study, adhering STROBE guidelines, was conducted using survey instrument previously validated through exploratory factor analysis assess newly approved vaccine. Methods: self-administered online distributed conveniently mainly across five The collected data on demographics, history, key constructs related vaccine attitude, including “Fear,” “Information,” “Accessibility,” “Benefits,” “Conspiracy.” Results: total 483 participants were included with majority from countries: Jordan ( n = 239, 49.5%), Kuwait 74, 15.3%), Egypt 68, 14.1%), Saudi Arabia 51, 10.6%), UAE 23, 4.8%), alongside other nations 28, 5.8%). Among respondents, 51.1% 247) expressed acceptance vaccine, 22.4% 108) hesitant, 26.5% 128) exhibited refusal. Multivariate identified perceived benefits (β 0.484, p < 0.001), information needs 0.229, previous history 0.087, 0.016) as positive predictors acceptance. Conversely, stronger conspiracy beliefs −0.083, 0.035) associated resistance. Fear accessibility not attitudes. Conclusion: findings showed benefits, access reliable information, are essential promote seniors. These recommended improve

Language: Английский

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Age and Gender Difference in the Association of Metabolic Syndrome and Peripheral Artery Disease Among Patients With Type 2 Diabetes Mellitus

International Journal of Vascular Medicine, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Purpose: Our study is aimed at exploring the association between peripheral artery disease (PAD) and metabolic syndrome (MetS) across different age gender groups among patients with Type 2 diabetes mellitus (T2DM). Patients Methods: A total of 3638 T2DM were enrolled in study, including 281 PAD 3357 without PAD. Demographic data anthropometric measurements, such as height, weight, waist circumference, collected. Laboratory tests ankle-brachial index (ABI) assessment also conducted. Multiple logistic regression was used to evaluate relationship number MetS components groups. Results: After adjusting for potential confounding factors, our results indicated that ORs presence increased progressively components. Stratified analysis showed this effect particularly pronounced younger (aged < 40 years) older ≥ 60 years), where risk rose an increasing Furthermore, positive significantly stronger females. Conclusions: In summary, findings suggest positively correlated T2DM, especially patients. Additionally, more evident female

Language: Английский

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Nirmatrelvir/ritonavir for patients with SARS-CoV-2 infection and impaired kidney function during the Omicron surge

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: March 22, 2023

Background: Nirmatrelvir/ritonavir has demonstrated effectiveness in high-risk patients with coronavirus disease 2019 (COVID-19). However, investigations on the efficacy and safety of nirmatrelvir/ritonavir kidney dysfunction are limited. Methods: Data were collected from admitted to a COVID-19 referral center Shanghai, China. Patients at least 18 years age had baseline estimated glomerular filtration rate (eGFR) <60 ml/min/1·73 m2. The primary endpoint was composite all-cause mortality, intensive care unit admission, or cardiovascular events. secondary viral shedding. Results: Among 195 participants, 73 received nirmatrelvir/ritonavir. A lower risk observed recipients compared non-recipients [adjusted HR 0.56 (95% CI: 0.32-0.96); p = 0.035]. experienced shorter duration shedding 3·70 (95%CI: 2.60-5.28); < 0.001) faster load clearance versus non-recipients. users, earlier initiation within 5 days since diagnosis related time (adjusted 7.84 [95% 3.28-18.76]; late initiation. No reported serious adverse events during treatment. Conclusion: Our findings support early for impaired function. This could improve patient outcomes shorten period.

Language: Английский

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Quantitative Synthesis of Factors Associated with COVID-19 Vaccine Acceptance and Vaccine Hesitancy in 185 Countries

Vaccines, Journal Year: 2023, Volume and Issue: 12(1), P. 34 - 34

Published: Dec. 28, 2023

Mass vaccination against COVID-19 is the best method to ensure herd immunity in order curb effect of pandemic on global economy. It therefore important assess determinants vaccine acceptance and hesitancy a scale. Factors were recorded from cross-sectional studies analyzed with t-Test, ANOVA, correlation, meta-regression analyses synthesized identify trends inform policy. We registered protocol (ID: CRD42022350418) used standard Cochrane methods PRISMA guidelines collect synthesize articles published between January 2020 August 2023. A total 67 576 185 countries involving 3081,766 participants included this synthesis. Global was 65.27% (95% CI; 62.72–67.84%), while stood at 32.1% 29.05–35.17%). One-Way ANOVA showed that there no significant difference percentage Gross Domestic Product spent procurement across World Bank income levels (p < 0.187). There 0.001) 0.005) different Income levels. level had strong influence 0.0004) 0.003) but did not. correlation (r = −0.11, p 0.164) or −0.09, 0.234). Meta-regression analysis living an urban setting (OR 4.83, 95% 0.67–212.8), rural 2.53, 0.29–119.33), older 1.98, 0.99–4.07), higher education 1.76, 0.85–3.81), being low earner 2.85, 0.45–30.63) increased odds high acceptance. influenza 33.06, 5.03–1395.01), mistrust for vaccines 3.91, 1.92–8.24), complacency 2.86, 1.02–8.83), pregnancy 2.3, 0.12–141.76), taking traditional herbs 2.15, 0.52–10.42), female 1.53, 0.78–3.01), safety concerns 1.29, 0.67–2.51). proposed number recommendations increase COVID-19.

Language: Английский

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The need for voices from the grassroots in China's public health system

The Lancet Regional Health - Western Pacific, Journal Year: 2023, Volume and Issue: 32, P. 100743 - 100743

Published: March 1, 2023

Language: Английский

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Poor nutritional status is associated with the severity of omicron infection in the older adults

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 15, 2024

Abstract Background The Omicron wave of Coronavirus disease 2019 (COVID-19) remains the dominant strain worldwide. studies nutritional status in geriatric people with COVID-19 variant are limited. Thus, aim this study was to investigate incidence poor among infected older patients, and explore correlation between severity infection patients. Methods This is a retrospective cross-sectional study. According clinical symptoms, patients were divided into two groups: mild moderate severe. Mini Nutritional Assessment short-form (MNA-SF) conducted when admitted defined as MNA-SF score 0–11. inflammatory markers including neutrophil lymphocyte ratio (NLR), platelet (PLR) systemic index (SII) calculated compared groups. Results Total 324 enrolled, median [interquartile range (IQR)] age 73 (17) years. Overall, 241 cases mild, 83 severe at time diagnosis that 54.3% had status. Patients found be ( P < 0.001) less vaccinated 0.001), longer virus shedding duration = 0.022), more comorbidities (≥ 2) 0.004) higher value NLR PLR SII 0.012). Vaccination, cycle threshold ORF1ab gene (OR CT value) female, negatively connected probability infection. For every 1 increase MNA-SF, odds decreased by 14.8% [adjusted (aOR), 0.852; 95% confidence interval (CI): 0.734–0.988; 0.034]. Conclusions Older likely develop

Language: Английский

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