Human Vaccines & Immunotherapeutics,
Journal Year:
2025,
Volume and Issue:
21(1)
Published: March 13, 2025
This
systematic
literature
review
summarizes
the
evidence
across
56
publications
and
pre-prints
(January
2020–July
2023)
with
low-risk
of
bias
based
on
JBI
critical
appraisal,
that
report
adjusted
estimates
for
relationship
between
COVID-19
vaccination
Post-COVID-19
Condition
(PCC)
by
timing
relative
to
infection
or
PCC-onset.
Comparisons
vaccine
effectiveness
(aVE)
against
≥1
PCC
(vs.
unvaccinated)
study
characteristics
known
impact
burden
VE
other
endpoints
were
possible
31
studies
where
preceded
infection.
Seventy-seven
percent
pre-infection
aVE
statistically
significant
(range:
7%–95%).
Statistically
slightly
higher
mRNA
14%–84%)
than
non-mRNA
vaccines
16%–38%)
ranges
before
during
Omicron
overlapped.
Our
findings
suggest
SARS-CoV-2
reduces
risk
regardless
type,
number
doses
received,
definition,
predominant
variant,
severity
acute
infections
included.
Nature Medicine,
Journal Year:
2024,
Volume and Issue:
30(8), P. 2148 - 2164
Published: Aug. 1, 2024
Long
COVID
represents
the
constellation
of
post-acute
and
long-term
health
effects
caused
by
SARS-CoV-2
infection;
it
is
a
complex,
multisystem
disorder
that
can
affect
nearly
every
organ
system
be
severely
disabling.
The
cumulative
global
incidence
long
around
400
million
individuals,
which
estimated
to
have
an
annual
economic
impact
approximately
$1
trillion-equivalent
about
1%
economy.
Several
mechanistic
pathways
are
implicated
in
COVID,
including
viral
persistence,
immune
dysregulation,
mitochondrial
dysfunction,
complement
endothelial
inflammation
microbiome
dysbiosis.
devastating
impacts
on
individual
lives
and,
due
its
complexity
prevalence,
also
has
major
ramifications
for
systems
economies,
even
threatening
progress
toward
achieving
Sustainable
Development
Goals.
Addressing
challenge
requires
ambitious
coordinated-but
so
far
absent-global
research
policy
response
strategy.
In
this
interdisciplinary
review,
we
provide
synthesis
state
scientific
evidence
assess
human
health,
systems,
economy
metrics,
forward-looking
roadmap.
Heart,
Journal Year:
2024,
Volume and Issue:
unknown, P. heartjnl - 323483
Published: March 12, 2024
Objective
To
study
the
association
between
COVID-19
vaccination
and
risk
of
post-COVID-19
cardiac
thromboembolic
complications.
Methods
We
conducted
a
staggered
cohort
based
on
national
campaigns
using
electronic
health
records
from
UK,
Spain
Estonia.
Vaccine
rollout
was
grouped
into
four
stages
with
predefined
enrolment
periods.
Each
stage
included
all
individuals
eligible
for
vaccination,
no
previous
SARS-CoV-2
infection
or
vaccine
at
start
date.
Vaccination
status
used
as
time-varying
exposure.
Outcomes
heart
failure
(HF),
venous
thromboembolism
(VTE)
arterial
thrombosis/thromboembolism
(ATE)
recorded
in
time
windows
after
infection:
0–30,
31–90,
91–180
181–365
days.
Propensity
score
overlap
weighting
empirical
calibration
were
to
minimise
observed
unobserved
confounding,
respectively.
Fine-Gray
models
estimated
subdistribution
hazard
ratios
(sHR).
Random
effect
meta-analyses
across
cohorts
databases.
Results
The
10.17
million
vaccinated
10.39
unvaccinated
people.
associated
reduced
risks
acute
(30-day)
post-acute
VTE,
ATE
HF:
example,
meta-analytic
sHR
0.22
(95%
CI
0.17
0.29),
0.53
(0.44
0.63)
0.45
(0.38
0.53),
respectively,
0–30
days
infection,
while
(0.40
0.70),
0.72
(0.58
0.88)
0.61
(0.51
0.73),
Conclusions
outcomes.
These
effects
more
pronounced
outcomes,
consistent
known
reductions
disease
severity
following
breakthrough
versus
infection.
Viruses,
Journal Year:
2024,
Volume and Issue:
16(7), P. 1060 - 1060
Published: June 30, 2024
Since
the
emergence
of
SARS-CoV-2
virus
in
2019,
nearly
700
million
COVID-19
cases
and
7
deaths
have
been
reported
globally.
Despite
most
individuals
recovering
within
four
weeks,
Center
for
Disease
Control
(CDC)
estimates
that
7.5%
to
41%
develop
post-acute
infection
syndrome
(PAIS),
known
as
'Long
COVID'.
This
review
provides
current
statistics
on
Long
COVID's
prevalence,
explores
hypotheses
concerning
epidemiological
factors,
such
age,
gender,
comorbidities,
initial
severity,
vaccine
interactions,
delves
into
potential
mechanisms,
including
immune
responses,
viral
persistence,
gut
dysbiosis.
Moreover,
we
conclude
women,
advanced
non-vaccination,
low
socioeconomic
status
all
appear
be
risk
factors.
The
reasons
these
differences
are
still
not
fully
understood
likely
involve
a
complex
relationship
between
social,
genetic,
hormonal,
other
Furthermore,
with
seem
more
endure
economic
hardship
due
persistent
symptoms.
In
summary,
our
findings
further
illustrate
multifaceted
nature
COVID
underscore
importance
understanding
factors
mechanisms
needed
effective
therapeutic
strategies
interventions.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(15), P. 8155 - 8155
Published: July 26, 2024
At
present,
COVID-19
remains
a
public
health
concern
due
to
the
ongoing
evolution
of
SARS-CoV-2
and
its
prevalence
in
particular
countries.
This
paper
provides
an
updated
overview
epidemiology
pathogenesis
COVID-19,
with
focus
on
emergence
variants
phenomenon
known
as
‘long
COVID’.
Meanwhile,
diagnostic
detection
advances
will
be
mentioned.
Though
many
inventions
have
been
made
combat
pandemic,
some
outstanding
ones
include
multiplex
RT-PCR,
which
can
used
for
accurate
diagnosis
infection.
ELISA-based
antigen
tests
also
appear
potential
tools
available
future.
discusses
current
treatments,
vaccination
strategies,
well
emerging
cell-based
therapies
The
underscores
necessity
us
continuously
update
scientific
understanding
treatments
it.
Cell Host & Microbe,
Journal Year:
2024,
Volume and Issue:
32(12), P. 2112 - 2130.e10
Published: Nov. 29, 2024
SARS-CoV-2
infection
is
associated
with
long-lasting
neurological
symptoms,
although
the
underlying
mechanisms
remain
unclear.
Using
optical
clearing
and
imaging,
we
observed
accumulation
of
spike
protein
in
skull-meninges-brain
axis
human
COVID-19
patients,
persisting
long
after
viral
clearance.
Further,
biomarkers
neurodegeneration
were
elevated
cerebrospinal
fluid
from
COVID
proteomic
analysis
skull,
meninges,
brain
samples
revealed
dysregulated
inflammatory
pathways
neurodegeneration-associated
changes.
Similar
distribution
patterns
SARS-CoV-2-infected
mice.
Injection
alone
was
sufficient
to
induce
neuroinflammation,
proteome
changes
axis,
anxiety-like
behavior,
exacerbated
outcomes
mouse
models
stroke
traumatic
injury.
Vaccination
reduced
but
did
not
eliminate
Our
findings
suggest
persistent
at
borders
may
contribute
lasting
sequelae
COVID-19.
