Emerging heterologous mRNA-based booster strategies within the COVID-19 vaccine landscape
Rituparna Das,
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Randall N. Hyer,
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Paul R. Burton
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et al.
Human Vaccines & Immunotherapeutics,
Journal Year:
2023,
Volume and Issue:
19(1)
Published: Jan. 2, 2023
Messenger
RNA
(mRNA)-based
vaccine
platforms
used
for
the
development
of
mRNA-1273
and
BNT162b2
have
provided
a
robust
adaptable
approach
to
offer
protection
against
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2).
However,
as
variants
concern
(VoCs),
such
omicron
associated
sub-variants,
emerge,
boosting
strategies
must
also
adapt
keep
pace
with
changing
landscape.
Heterologous
vaccination
regimens
involving
administration
booster
vaccines
different
than
primary
series
practical,
effective,
safe
continue
reduce
global
burden
disease
2019
(COVID-19).
To
understand
immunogenicity,
effectiveness,
safety
heterologous
mRNA-based
strategies,
relevant
clinical
real-world
observational
studies
were
identified
summarized.
Overall,
that
are
currently
available
those
in
will
play
an
important
role
protecting
individuals
from
COVID-19
caused
by
emerging
VoCs.
Language: Английский
Innate immune responses to three doses of the BNT162b2 mRNA SARS-CoV-2 vaccine
Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: Aug. 22, 2022
To
explore
the
effects
of
SARS-CoV-2-mRNA
vaccines
on
innate
immune
responses
we
enrolled
58
individuals
who
received
3
doses
BNT162b2
vaccine
in
a
longitudinal
study;
45
these
had
never
been
SARS-CoV-2
infected.
Results
showed
that
vaccination
significantly
increased:
1)
classical
and
intermediate
inflammatory
monocytes,
2)
CD56bright,
CD56dim,
CD56dim/CD16dim
NK
cells,
3)
IFN-γ+
;production
as
well
perforin
granzyme
content
by
cells.
Vaccination
also
reduced
expression
inhibitory
receptor
ILT-2,
increasing
stimulatory
molecule
2DS2.
These
were
long-lasting
boosted
every
dose.
Notably,
ILT-2
expressing
cells
even
more
robustly
COVID-19-recovereed
vaccines.
BNT162b1
mRNA
is
known
to
induce
potent
adaptive
responses;
results
herein
show
its
ability
modulate
well,
offering
further
support
indication
proceed
with
worldwide
efforts
end
pandemic.
Language: Английский
Booster Doses of Anti COVID-19 Vaccines: An Overview of Implementation Policies among OECD and EU Countries
Fabrizio Bert,
No information about this author
Giacomo Scaioli,
No information about this author
Lorenzo Vola
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et al.
International Journal of Environmental Research and Public Health,
Journal Year:
2022,
Volume and Issue:
19(12), P. 7233 - 7233
Published: June 13, 2022
The
need
for
an
anti-COVID-19
booster
dose
posed
organizational
challenge
health
policy
makers
worldwide.
Therefore,
this
study
aimed
to
explore
the
policies
regarding
through
overview
of
recommendations
issued
in
high-income
countries.
Between
10
November
and
16
December
2021,
authors
searched
state-level
official
documents
about
offer
dose,
considering
43
countries
belonging
European
Union
(EU)
or
Organisation
Economic
Co-operation
Development
(OECD).
Mainly
due
lack
English
translation,
15
were
excluded.
A
total
135
selected.
Almost
all
started
administering
between
September
2021.
most
used
products
mRNA
vaccines,
followed
by
Vaxzevria-AstraZeneca
Jcovden-Janssen/Johnson
&
Johnson.
All
established
criteria
define
categories
individuals
be
vaccinated
as
a
priority.
six/five-months
interval
was
main
choice
general
population
with
while
shorter
intervals
chosen
vulnerable
other
vaccines.
Despite
diversities
related
differences
systems,
economical
resources,
numbers,
adapt
these
factors
massive
vaccination
campaign,
progressive
convergence
towards
same
highlighted.
Language: Английский
How do we change our approach to COVID with the changing face of disease?
Expert Review of Anti-infective Therapy,
Journal Year:
2024,
Volume and Issue:
22(5), P. 279 - 287
Published: April 20, 2024
Introduction
The
emergence
of
SARS-CoV-2
triggered
a
global
health
emergency,
causing
>
7
million
deaths
thus
far.
Limited
early
knowledge
spurred
swift
research,
treatment,
and
vaccine
developments.
Implementation
public
measures
such
as,
lockdowns
social
distancing,
disrupted
economies
strained
healthcare.
Viral
mutations
highlighted
the
need
for
flexible
strategies
strong
infrastructure,
with
collaboration
crucial
pandemic
control.
Language: Английский
The impact of COVID-19 booster vaccination on reducing mortality in patients hospitalized with COVID-19 at Sisaket Hospital
Nidhikul Tem-eiam
No information about this author
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
68(3)
Published: July 25, 2024
The
COVID-19
vaccine
has
the
potential
to
decrease
hospitalizations
and
fatalities,
even
when
different
types
are
administered.
Towards
end
of
2021,
during
ongoing
pandemic,
there
were
guidelines
suggesting
administration
booster
shots
following
completion
primary
series.
Consequently,
this
study
aims
investigate
efficacy
vaccinations
timing
between
in
terms
preventing
fatalities
among
COVID-19-infected
patients
receiving
care
at
Si
Sa
Ket
Hospital
Language: Английский
COMPARISON OF CLINICAL OUTCOMES OF CORONAVAC VACCINATED AND UNVACCINATED OLDER ADULTS WITH HOSPITALIZED COVID-19
The Turkish Journal of Geriatrics,
Journal Year:
2022,
Volume and Issue:
unknown
Published: Dec. 28, 2022
Language: Английский
Strategy Program for Reducing Doubt on Covid-19 Vaccination in Tambraw Regency, West Papua
Butet Agustarika,
No information about this author
Alva Cherry Mustamu,
No information about this author
Situmorang Panel
No information about this author
et al.
JURNAL KREATIVITAS PENGABDIAN KEPADA MASYARAKAT (PKM),
Journal Year:
2022,
Volume and Issue:
5(11), P. 3933 - 3943
Published: Nov. 1, 2022
ABSTRACT
Covid-19
vaccination
aims
to
minimize
the
spread
of
Covid-19,
reduce
number
positive
and
death
due
reach
immunity
group
(herd
)
protect
Public
from
stay
productive
by
social
economic.
Some
strategies
can
increase
reception
booster
vaccines,
i.e.
advocacy
local,
national
international
for
equal
access
COVID-19
tests
treatments,
calling
monitoring
action
specific
required
producers,
governments
multilateral
actors.
Mobilize
empower
community,
including
through
media
networks
produce
influential
vaccine.
Sue
overcome
Contributing
misinformation
misperception
doubt
Purpose
implementation
activity
programs
this
is
doing
strategy
World
Health
Organization
recommended
vaccinations,
namely
seminars
giving
non-financial
incentives
as
well
board
advertisement
capable
lower
level
Devotion
conducted
with
several
steps
that
conduct
on
importance
vaccinating
basic
advanced
(booster)
covid-19,
do
publication
about
covid-19
vaccine
using
leaflets,
leaflets
boards
billboard
corner
Street,
gift
incentive
in
form
goods,
needs
a
tree.
Next
held
start
at
same
time
given
goods
need
This
Seminar
FGD
inviting
representatives
agency
government
related,
police
soldier,
Puskesmas
heads
district.
Problems
found
awareness
consequence,
ignorance
vaccination,
distance
implementation.
Together
To
follow-up
share
task.
Vaccination
progress
one
day
ends
distribution
tree
participant
vaccination.
Attendees
many
572
people,
did
dose
first
much
134,
second
359
people
continued
79
people.
The
results
service
beginning
nor
continued.
problem
society
consequence
lack
information
Moment
solving
shared
task
each
government,
then
solution
deployment
accommodate
going
place
Because
that,
interest
Becomes
increased
Community
future
be
focused
increasing
public
which
also
involves
relevant
agencies.
Keywords:
Booster,
Vaccine,
Devotion,
Herd
Immunity
Language: Английский