Limited evidence of association between dysregulated immune marker levels and telomere length in severe mental disorders DOI
Monica Bettina Elkjær Greenwood Ormerod, Thor Ueland, Monica Aas

et al.

Acta Neuropsychiatrica, Journal Year: 2025, Volume and Issue: 37

Published: Jan. 1, 2025

Abstract Objective: Accelerated ageing indexed by telomere attrition is suggested in schizophrenia spectrum- (SCZ) and bipolar disorders (BD). While inflammation may promote shortening, few studies have investigated the association between length (TL) markers of immune activation severe mental disorders. Methods: Leucocyte TL defined as template/amount single-copy gene template (T/S ratio), was determined participants with SCZ ( N = 301) or BD 211) a healthy control group (HC, 378). analysed linear regressions for associations levels 12 linked to BD. Adjustments were made broad range potential confounding variables. measured quantitative polymerase chain reaction (qPCR) enzyme immunoassays. Results: A positive soluble tumour necrosis factor receptor 1A (sTNF-R1) β 0.191, p 0.012) observed. Plasma other not significantly associated BD, HC groups. Conclusion: There limited evidence The results provide little support involvement dysregulation, reflected current systemic markers, attrition-related accelerated

Language: Английский

Neuroinflammation and schizophrenia – is there a link? DOI Creative Commons
Cristiano Chaves, Serdar Dursun, Massimo Tusconi

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 8, 2024

Keywords: inflammation, schizophrenia, biomarkers, psychiatric genetics, neurobiology, neuroinflammation, psychotic disorders

Language: Английский

Citations

6
Natural compounds for oxidative stress and neuroprotection in schizophrenia: composition, mechanisms, and therapeutic potential DOI

Anam N. Khan,

Rahul D. Jawarkar, Magdi E. A. Zaki

et al.

Nutritional Neuroscience, Journal Year: 2024, Volume and Issue: 27(11), P. 1306 - 1320

Published: March 11, 2024

Objective An imbalance between the generation of reactive oxygen species (ROS) and body's antioxidant defense mechanisms is believed to be a critical factor in development schizophrenia (SCZ) like neurological illnesses. Understanding roles ROS SCZ potential activity natural antioxidants against could lead more effective therapeutic options for prevention treatment illness.

Language: Английский

Citations

6
Immune-based Machine learning prediction of diagnosis and illness state in schizophrenia and bipolar disorder DOI Creative Commons
Katrien Skorobogatov, Livia De Picker, Ching‐Lien Wu

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 122, P. 422 - 432

Published: Aug. 14, 2024

Schizophrenia and bipolar disorder frequently face significant delay in diagnosis, leading to being missed or misdiagnosed early stages. Both disorders have also been associated with trait state immune abnormalities. Recent machine learning-based studies shown encouraging results using diagnostic biomarkers predictive models, but few focused on immune-based markers. Our main objective was develop supervised learning models predict diagnosis illness schizophrenia only a panel of peripheral kynurenine metabolites cytokines.

Language: Английский

Citations

6
The neutrophil-to-Lymphocyte ratio is associated with clinical symptoms in first-episode medication-naïve patients with schizophrenia DOI Creative Commons
Xuan Wang, Xiaofang Chen,

Xiaoni Guan

et al.

Schizophrenia, Journal Year: 2024, Volume and Issue: 10(1)

Published: Feb. 3, 2024

Abstract Innate immunity has been shown to be associated with schizophrenia (Sch). This study explored the relationship between symptoms and neutrophil-to-lymphocyte ratio (NLR) (a marker of innate immunity) in patients Sch. Ninety-seven first-episode medication-naïve (FEMN) Sch 65 healthy controls were recruited this study. We measured complete blood count assessed clinical using PANSS scales. found higher NEU counts NLR compared control subjects. Male showed a than female patients. In addition, FEMN values PANSS-p, PANSS-g, PANSS-total scores (all p < 0.05). Regression analysis revealed that was predictor for total Higher value observed significant associations psychotic indicate an imbalance inflammation immune system may involved pathophysiology

Language: Английский

Citations

5
Association between psychiatric admissions in patients with schizophrenia and IL-6 plasma levels polygenic score DOI
Fernando Facal, Manuel Arrojo, Mario Páramo

et al.

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2024, Volume and Issue: 274(7), P. 1671 - 1679

Published: March 16, 2024

Language: Английский

Citations

5
Association of Single Nucleotide Polymorphisms of Cytokine Genes with Depression, Schizophrenia and Bipolar Disorder DOI Open Access

Ekaterina V. Mikhalitskaya,

N. Vyalova, Evgeny A. Ermakov

et al.

Genes, Journal Year: 2023, Volume and Issue: 14(7), P. 1460 - 1460

Published: July 17, 2023

Immune gene variants are known to be associated with the risk of psychiatric disorders, their clinical manifestations, and response therapy. This narrative review summarizes current literature over past decade on association polymorphic cytokine genes risk, severity, treatment for severe mental disorders such as bipolar disorder, depression, schizophrenia. A search in databases was carried out using keywords related depressive schizophrenia, inflammation, cytokines. Gene lists were extracted from publications identify common pathways these disorders. Associations between IL1B, IL6, TNFA most replicated relevant depression. Polymorphic IL6R, IL10, IL17A, have been Bipolar disorder has mainly IL1B gene. Interestingly, IL6R polymorphism (rs2228145) all three diseases. Some also presentation pharmacotherapy. There is evidence that some specific may affect expression genes. Thus, data this indicate a link neuroinflammation

Language: Английский

Citations

11
Free water alterations in different inflammatory subgroups in schizophrenia DOI

Dongsheng Wu,

Qi Wu, Fei Li

et al.

Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 115, P. 557 - 564

Published: Nov. 14, 2023

Language: Английский

Citations

11
The neutrophil-lymphocyte ratio in first-episode medication-naïve patients with schizophrenia: A 12-week longitudinal follow-up study DOI

Xiaobing Lu,

Qianqian Sun,

Ling Wu

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2024, Volume and Issue: 131, P. 110959 - 110959

Published: Feb. 2, 2024

Language: Английский

Citations

4
Association of symptom severity and cerebrospinal fluid alterations in recent onset psychosis in schizophrenia-spectrum disorders – An individual patient data meta-analysis DOI Creative Commons
Mattia Campana, Vladislav Yakimov, Joanna Moussiopoulou

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 119, P. 353 - 362

Published: April 10, 2024

Neuroinflammation and blood-cerebrospinal fluid barrier (BCB) disruption could be key elements in schizophrenia-spectrum disorderś(SSDs) etiology symptom modulation. We present the largest two-stage individual patient data (IPD) meta-analysis, investigating association of BCB cerebrospinal (CSF) alterations with severity first-episode psychosis (FEP) recent onset psychotic disorder (ROP) individuals, a focus on sex-related differences. Data was collected from PubMed EMBASE databases. FEP, ROP high-risk syndromes for IPD were included if routine basic CSF-diagnostics reported. Risk bias studies evaluated. Random-effects meta-analyses mixed-effects linear regression models employed to assess impact severity. Published (6 studies) unpublished n = 531 individuals analyses. CSF altered 38.8 % individuals. No significant differences found between without (SMD -0.17, 95 %CI -0.55-0.22, p 0.341). However, males elevated CSF/serum albumin ratios or any alteration had significantly higher positive scores than those 0.34, 0.05-0.64, 0.037 SMD 0.29, 0.17-0.41p 0.005, respectively). Mixed-effects simple showed no (p > 0.1) parameters symptomatic outcomes. interaction sex 0.1). appears highly prevalent early involved symptomś males, indicating potential difficult-to-treat states. This work highlights need considering breakdownand SSDs clinical trials treatment strategies.

Language: Английский

Citations

4
Elevated serum kynurenic acid in individuals with first-episode psychosis and insufficient response to antipsychotics DOI Creative Commons
Alexandros Hatzimanolis,

Stefania Foteli,

Lida‐Alkisti Xenaki

et al.

Schizophrenia, Journal Year: 2024, Volume and Issue: 10(1)

Published: July 10, 2024

Abstract The tryptophan-metabolizing kynurenine pathway (KP) can be activated by enhanced inflammatory responses and has been implicated in the pathophysiology of schizophrenia. However, there is little evidence for KP dysregulation early course psychotic illness. We aimed to investigate potential immune-mediated hyperactivity individuals with first-episode psychosis (FEP) relationship symptom severity treatment response outcomes. Serum immunoassays were performed measure peripheral levels cytokines (IL-1β, IL-10, TNF-a), rate-limiting enzymes (IDO/TDO), kynurenic acid (KYNA) metabolite 104 antipsychotic-naïve patients FEP 80 healthy controls (HC). Positive Negative Syndrome Scale (PANSS) Global Assessment Functioning (GAF) administered assess psychopathology functioning status at admission following 4-week antipsychotics. Cytokine components substantially increased compared HC, before after antipsychotic treatment. A significant positive correlation between pro-inflammatory IL-1β KYNA was observed among patients, but not HC. Importantly, within-patient analysis revealed that those higher baseline experienced more severe negative symptoms poorer clinical improvement follow-up. These findings suggest upregulated psychosis, likely through induction IL-1β-dependent pathways, raised might represent a promising indicator non-response medication FEP.

Language: Английский

Citations

4