Associations between socioeconomic status and mental health trajectories during early adolescence: Findings from the Adolescent Brain Cognitive Development study

JCPP Advances, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Abstract Background Low socioeconomic status (SES) during childhood is associated with higher levels of youth psychopathology. However, limited longitudinal work has examined the role both household and neighborhood SES in shaping mental health trajectories over time using population‐based data. The goal present study was to characterize associations between changes problems early adolescence. Methods We investigated independent joint income‐to‐needs ratio, parent educational attainment, material hardship, disadvantage internalizing, externalizing, attention symptom data from Adolescent Brain Cognitive Development (ABCD) Study. Given sex‐based differences ABCD study, analyses were conducted separately males females. assessed at baseline youth‐reported across six time‐points age 10–13 years ( M = 10.4, SD 0.63 years; first 6‐month follow‐up; N 9488). Results Main effects indicated that, general, high lower symptoms. longitudinally, increases relative SES. In females, while internalizing symptoms increased all income‐to‐needs, association most positive B 0.036, SE 0.008, p < 0.001). males, positively predicted externalizing 0.022, 0.007, 0.002) 0.023, 0.001) trajectories, linked income‐to‐needs. Two‐way interactions indicators predicting non‐significant. Conclusion Our finding that lower‐SES backgrounds exhibited adolescence contrasts findings prior cross‐sectional studies. are on rise landscape risk for psychopathology changing. More research needed understand how contributes resilience transition

Language: Английский

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Environmental and neurodevelopmental contributors to youth mental illness

Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 50(1), P. 201 - 210

Published: July 19, 2024

Abstract While a myriad of factors likely contribute to the development mental illness in young people, social environment (including early adverse experiences) concert with neurodevelopmental alterations is undeniably important. A number influential theories make predictions about how and why may mediate or moderate effects on emergence illness. Here, we discuss current evidence supporting each these theories. Although this area research rapidly growing, body still relatively limited. However, there exist some consistent findings, including increased striatal reactivity during positive affective processing larger hippocampal volumes being associated vulnerability susceptibility environments internalizing symptoms. Limited longitudinal work has investigated mechanisms linking health. Drawing from human insights animal studies, propose an integrated mediation-moderation model outline future directions advance field.

Language: Английский

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Shared Genetic Architecture Between Schizophrenia and Anorexia Nervosa: A Cross-trait Genome-Wide Analysis

Schizophrenia Bulletin, Journal Year: 2024, Volume and Issue: 50(5), P. 1255 - 1265

Published: June 7, 2024

Abstract Background and Hypothesis Schizophrenia (SCZ) anorexia nervosa (AN) are 2 severe highly heterogeneous disorders showing substantial familial co-aggregation. Genetic factors play a significant role in both disorders, but the shared genetic etiology between them is yet to be investigated. Study Design Using summary statistics from recent large genome-wide association studies on SCZ (Ncases = 53 386) AN 16 992), 2-sample Mendelian randomization analysis was conducted explore causal relationship AN. MiXeR employed quantify their polygenic overlap. A conditional/conjunctional false discovery rate (condFDR/conjFDR) framework adopted identify loci jointly associated with disorders. Functional annotation enrichment analyses were performed loci. Results We observed cross-trait enrichment, suggestive bidirectional relationship, considerable overlap (Dice coefficient 62.2%) The proportion of variants concordant effect directions among all 69.9%. Leveraging overlapping associations, we identified 6 novel for 33 at condFDR &lt;0.01. At conjFDR &lt;0.05, 10 implicating multiple genes expressed cerebellum pituitary involved synapse organization. Particularly, high expression hippocampus adolescence orbitofrontal cortex during infancy. Conclusions This study provides insights into by revealing component offers window complex etiology.

Language: Английский

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Associations of socioeconomic status with cognitive function, language ability, and academic achievement in youth: a systematic review of mechanisms and protective factors

Journal of Child Psychology and Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Low socioeconomic status (SES) is negatively associated with children's cognitive and academic performance, leading to long‐term educational economic disparities. In particular, SES a powerful predictor of executive function (EF), language ability, achievement. Despite extensive research documenting SES‐related differences in these domains, our understanding the mechanisms underlying associations factors that may mitigate relationships limited. This systematic review aimed identify mediators moderators association EF, Our synthesis revealed stress, support, stimulation, broader contextual at school‐ neighborhood level be important protective associations. stimulation mediated Educational expectations, classroom school environment, teacher–student also played key role addition, such as preschool attendance, home learning activities, parental support buffered between low lower outcomes. We discuss findings context interventions help reduce

Language: Английский

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The role of socioeconomic status in shaping associations between sensory association cortex and prefrontal structure and implications for executive function

Developmental Cognitive Neuroscience, Journal Year: 2025, Volume and Issue: unknown, P. 101550 - 101550

Published: March 1, 2025

Language: Английский

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Altered neurovascular coupling in depression with childhood maltreatment

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111348 - 111348

Published: April 1, 2025

Language: Английский

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Differential patterns of axonal loss associated with threat-related adversity in atypical depression and non-atypical depression

NeuroImage Clinical, Journal Year: 2025, Volume and Issue: 46, P. 103786 - 103786

Published: Jan. 1, 2025

Major depressive disorder (MDD) encompasses a broad spectrum of heterogeneous symptoms arising from distinct etiological mechanisms. Phenotypic markers psychopathology are most likely influenced by exposure to childhood maltreatment, yielding subtypes within conventional diagnostic boundaries. However, the biological interactions between MDD and types trauma remain unclear. 50 atypical depression (AD) patients, 97 non-AD patients healthy controls were included complete multi-shell diffusion MRI scans clinical assessments. Differential tractography was performed clarify axonal injury AD groups. Moreover, correlational employed individually assess relationship quantitative anisotropy (QA) all in each depressed subgroup. Our study found that had differential loss primarily involving bilateral superior longitudinal fasciculus, arcuate inferior parietal aslant tract, corpus callosum. Furthermore, showed significantly negative associations QA values, total scores, threat-related adversity, while positive observed patients. similar phenomena not for deprivation-related adversities. findings indicate spatial patterns alterations associated with adversity non-atypical depression. Efforts attenuate consequences maltreatment should consider specific manifestations.

Language: Английский

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Anterior-posterior systematic deficits of cortical thickness in early-onset schizophrenia

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: May 21, 2025

Schizophrenia is a neurodevelopmental condition with alterations in both sensory and association cortical areas. These have been reported to follow structural connectivity patterning, occur system-level fashion. Here we investigated whether pathological of schizophrenia originate from an early disruption organization. We found covariance gradient axis thickness discriminated anterior posterior region was compressed early-onset (EOS) patients. Patients showed increased between two ends the anterior-posterior axis, geodesic distance covarying regions ends. Positive symptoms strengthening Our findings revealed contracted organizational EOS patients, which attributed excessive distally coordinated changes regions. study systematic perspective suggests disturbed maturational processes EOS, supporting hypothesis schizophrenia.

Language: Английский

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Brain development

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 43 - 57

Published: Jan. 1, 2024

Language: Английский

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Environmental and neurodevelopmental contributors to youth mental illness

Published: March 18, 2024

While a myriad of factors likely contribute to the development mental illness in young people, social environment (including early adverse experiences) concert with neurodevelopmental alterations are undeniably important. A number influential theories make predictions about how and why may mediate or moderate effects on emergence illness. Here, we discuss current evidence supporting each these theories. Although this area research is rapidly growing, body still relatively limited. However, there exist some consistent findings, including increased striatal reactivity during positive affective processing larger hippocampal volumes being associated vulnerability susceptibility environments internalizing symptoms. Limited longitudinal work has investigated mechanisms linking health. Drawing from human insights animal studies, propose an integrated mediation-moderation model outline future directions advance field.

Language: Английский

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