Biomedical Applications of MXenes: From Nanomedicine to Biomaterials DOI
Liang Chen, Xinyue Dai, Wei Feng

et al.

Accounts of Materials Research, Journal Year: 2022, Volume and Issue: 3(8), P. 785 - 798

Published: July 18, 2022

ConspectusThe rise of two-dimensional (2D) materials has led to significant interest in their potential applications for nanomedicine and biomaterials the hope that they can overcome some intrinsic limitations conventional theranostic materials. MXenes, an emerging family 2D mainly made transition metal carbides/nitrides, have drawn substantial biomedical because unique physicochemical properties. The remarkable photothermal energy-converting capability MXenes allows photonic hyperthermia treatment second near-infrared biowindow with deep tissue penetration. diverse choice elements endows them aptitudes act as contrast agents computed tomography magnetic resonance imaging. As understanding pathological characteristics is improved, desirable properties performances become more comprehensive, which unlikely be accomplished formulation alone.In this Account, we highlight recent progress ranging from biomaterials. We will start by introducing major synthetic techniques fabricating ultrathin structures nanoscale sizes purposes. then elaborate how differ other materials, showing exclusive applications. surface compositions allow tuning bandgap plasmon effect, essential nanodynamic therapy. could render enzymatic activities nanocatalytic also possess favorable biodegradability biocompatibility, facilitating clinical translation.However, might insufficient fulfill specific requirements advanced For instance, therapeutic efficiency alone would impaired reasons such low tumor accumulation nanomedicine, inclined thermal resistance cancer cells, hypoxic microenvironment. In addition, are limited therapy or theranostics. been integrated functional components tackle these issues. Thus, further discuss strategies fabricate MXene-based different dimensional a broad range applications, localized regeneration. Several methods modify demonstrated increase stability MXene physiological media. Decorating 0D nanoparticles enables combination imaging modalities. Integrating layered improved efficiency, 3D implantable discussed.

Language: Английский

Preparation of amorphous MOF based biomimetic nanozyme with high laccase- and catecholase-like activity for the degradation and detection of phenolic compounds DOI

Jinghui Wang,

Renliang Huang, Wei Qi

et al.

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 434, P. 134677 - 134677

Published: Jan. 13, 2022

Language: Английский

Citations

120
Plasmonic Nanozyme of Graphdiyne Nanowalls Wrapped Hollow Copper Sulfide Nanocubes for Rapid Bacteria‐Killing DOI
Qiang Bai,

Manman Liang,

Wen‐Li Wu

et al.

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(20)

Published: Feb. 9, 2022

Abstract Plasmon stimulation represents an appealing way to modulate enzyme mimic functions, but utilization efficiency of plasmon excitation remains relatively low. To overcome this drawback, a heterojunction composite based on graphdiyne nanowalls wrapped hollow copper sulfide nanocubes (CuS@GDY) with strong localized surface resonance (LSPR) response in the near‐infrared (NIR) region is developed. This nanozyme can concurrently harvest LSPR induced hot carriers and produce photothermal effects, resulting dramatically increased peroxidase‐like activity when exposed 808 nm light. Both experimental results theoretical calculations show that remarkable catalytic performance CuS@GDY due unique hierarchical structure, narrow bandgap GDY nanowalls, effect CuS nanocages, fast interfacial electron transfer dynamics, carbon vacancies CuS@GDY. plasmonic exhibits rapid, efficient, broad‐spectrum antibacterial ( > 99.999%) against diverse pathogens (methicillin‐resistant Staphylococcus aureus , Escherichia coli ). study not only sheds light mechanism nanozyme‐/photocatalysis coupling process, also opens up new avenue for engineering NIR driven nanozymes rapid synergistic photo‐enhanced therapy.

Language: Английский

Citations

113
A Molybdenum Disulfide Nanozyme with Charge‐Enhanced Activity for Ultrasound‐Mediated Cascade‐Catalytic Tumor Ferroptosis DOI
Longwei Wang, Xiaodi Zhang, Zhen You

et al.

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 62(11)

Published: Dec. 31, 2022

Abstract The deficient catalytic activity of nanozymes and insufficient endogenous H 2 O in the tumor microenvironment (TME) are major obstacles for nanozyme‐mediated therapy. Since electron transfer is basic essence catalysis‐mediated redox reactions, we explored contributing factors enzymatic based on positive negative charges, which experimentally theoretically demonstrated to enhance peroxidase (POD)‐like a MoS nanozyme. Hence, an acidic microenvironment‐responsive ultrasound‐mediated cascade nanocatalyst (BTO/MoS @CA) presented that made from few‐layer nanosheets grown surface piezoelectric tetragonal barium titanate (T‐BTO) modified with pH‐responsive cinnamaldehyde (CA). integration CA‐mediated self‐supply, charge‐enhanced activity, glutathione (GSH) depletion enables out‐of‐balance homeostasis, leading effective ferroptosis minimal side effects.

Language: Английский

Citations

108
Nanozyme-based pollutant sensing and environmental treatment: Trends, challenges, and perspectives DOI Creative Commons
Ragini Singh, Akhela Umapathi,

Gaurang Patel

et al.

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 854, P. 158771 - 158771

Published: Sept. 13, 2022

Language: Английский

Citations

100
Biomedical Applications of MXenes: From Nanomedicine to Biomaterials DOI
Liang Chen, Xinyue Dai, Wei Feng

et al.

Accounts of Materials Research, Journal Year: 2022, Volume and Issue: 3(8), P. 785 - 798

Published: July 18, 2022

ConspectusThe rise of two-dimensional (2D) materials has led to significant interest in their potential applications for nanomedicine and biomaterials the hope that they can overcome some intrinsic limitations conventional theranostic materials. MXenes, an emerging family 2D mainly made transition metal carbides/nitrides, have drawn substantial biomedical because unique physicochemical properties. The remarkable photothermal energy-converting capability MXenes allows photonic hyperthermia treatment second near-infrared biowindow with deep tissue penetration. diverse choice elements endows them aptitudes act as contrast agents computed tomography magnetic resonance imaging. As understanding pathological characteristics is improved, desirable properties performances become more comprehensive, which unlikely be accomplished formulation alone.In this Account, we highlight recent progress ranging from biomaterials. We will start by introducing major synthetic techniques fabricating ultrathin structures nanoscale sizes purposes. then elaborate how differ other materials, showing exclusive applications. surface compositions allow tuning bandgap plasmon effect, essential nanodynamic therapy. could render enzymatic activities nanocatalytic also possess favorable biodegradability biocompatibility, facilitating clinical translation.However, might insufficient fulfill specific requirements advanced For instance, therapeutic efficiency alone would impaired reasons such low tumor accumulation nanomedicine, inclined thermal resistance cancer cells, hypoxic microenvironment. In addition, are limited therapy or theranostics. been integrated functional components tackle these issues. Thus, further discuss strategies fabricate MXene-based different dimensional a broad range applications, localized regeneration. Several methods modify demonstrated increase stability MXene physiological media. Decorating 0D nanoparticles enables combination imaging modalities. Integrating layered improved efficiency, 3D implantable discussed.

Language: Английский

Citations

96