Breaking the pH Limitation of Nanozymes: Mechanisms, Methods, and Applications

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(31)

Published: April 14, 2024

Although nanozymes have drawn great attention over the past decade, activities of peroxidase-like, oxidase-like, and catalase-like are often pH dependent with elusive mechanism, which largely restricts their application. Therefore, a systematical discussion on pH-related catalytic mechanisms together methods to overcome this limitation is in need. In review, various exhibiting pH-dependent collected root causes for dependence comprehensively analyzed. Subsequently, regulatory concepts including environment reconstruction direct activity improvement break restriction summarized. Moreover, applications pH-independent sensing, disease therapy, pollutant degradation overviewed. Finally, current challenges future opportunities development suggested. It anticipated that review will promote further design broaden application range higher efficiency.

Language: Английский

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Nanozymes: powerful catalytic materials for environmental pollutant detection and degradation

Environmental Science Nano, Journal Year: 2024, Volume and Issue: 11(3), P. 766 - 796

Published: Jan. 1, 2024

Here we made a critical review on nanozyme-involved detection and degradation of environmental pollutants, the research progress achieved in last five years was emphatically concluded.

Language: Английский

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Novel nanozyme Ag/Fe3O4@h-BN with peroxidase-mimicking and oxidase-mimicking activities for dye degradation, As(V) removal and detection

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 461, P. 141589 - 141589

Published: Feb. 11, 2023

Language: Английский

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Single-atom nanozymes: Emerging talent for sensitive detection of heavy metals

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 242, P. 114093 - 114093

Published: July 14, 2024

Language: Английский

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Oxidase mimicking nanozyme: Classification, catalytic mechanisms and sensing applications

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 520, P. 216166 - 216166

Published: Aug. 22, 2024

Language: Английский

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Nanozyme‐Enabled Biomedical Diagnosis: Advances, Trends, and Challenges

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 13, 2024

Abstract As nanoscale materials with the function of catalyzing substrates through enzymatic kinetics, nanozymes are regarded as potential alternatives to natural enzymes. Compared protein‐based enzymes, exhibit attractive characteristics low preparation cost, robust activity, flexible performance adjustment, and versatile functionalization. These advantages endow them wide use from biochemical sensing environmental remediation medical theranostics. Especially in biomedical diagnosis, feature catalytic signal amplification provided by makes emerging labels for detection biomarkers diseases, rapid developments observed recent years. To provide a comprehensive overview progress made this dynamic field, here an diagnosis enabled is provided. This review first summarizes synthesis nanozyme then discusses main strategies applied enhance their activity specificity. Subsequently, representative utilization combined biological elements disease reviewed, including related metabolic, cardiovascular, nervous, digestive diseases well cancers. Finally, some development trends nanozyme‐enabled highlighted, corresponding challenges also pointed out, aiming inspire future efforts further advance promising field.

Language: Английский

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Elucidating the catalytic mechanism of Prussian blue nanozymes with self-increasing catalytic activity

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 13, 2024

Abstract Although Prussian blue nanozymes (PBNZ) are widely applied in various fields, their catalytic mechanisms remain elusive. Here, we investigate the long-term performance of PBNZ as peroxidase (POD) and catalase (CAT) mimetics to elucidate lifespan underlying mechanisms. Unlike our previously reported Fe 3 O 4 nanozymes, which exhibit depletable POD-like activity, POD CAT-like activities not only persist but slightly enhance over prolonged catalysis. We demonstrate that irreversible oxidation significantly promotes catalysis, leading self-increasing activities. The process pre-oxidized can be initiated through either conduction band pathway or valence pathway. In summary, reveal follows a dual-path electron transfer mechanism during offering advantage long service life.

Language: Английский

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Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.

Language: Английский

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Recent advances and challenges of double-atom catalysts in diverse environmental applications: A state-of-the-art review

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 532, P. 216545 - 216545

Published: Feb. 19, 2025

Language: Английский

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Co‐based Nanozymatic Profiling: Advances Spanning Chemistry, Biomedical, and Environmental Sciences

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(8)

Published: Sept. 19, 2023

Nanozymes, next-generation enzyme-mimicking nanomaterials, have entered an era of rational design; among them, Co-based nanozymes emerged as captivating players over times. been developed and garnered significant attention the past five years. Their extraordinary properties, including regulatable enzymatic activity, stability, multifunctionality stemming from magnetic photothermal conversion effects, cavitation relaxation efficiency, made a rising star. This review presents first comprehensive profiling in chemistry, biology, environmental sciences. The begins by scrutinizing various synthetic methods employed for nanozyme fabrication, such template sol-gel methods, highlighting their distinctive merits chemical standpoint. Furthermore, detailed exploration wide-ranging applications biosensing biomedical therapeutics, well contributions to monitoring remediation is provided. Notably, drawing inspiration state-of-the-art techniques omics, analysis undertaken, employing analogous statistical methodologies provide valuable guidance. To conclude, outlook on challenges prospects presented, spanning microscopic physicochemical mechanisms macroscopic clinical translational applications.

Language: Английский

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