Advances in nanomedicines for lymphatic imaging and therapy

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Aug. 24, 2023

Abstract Lymph nodes play a pivotal role in tumor progression as key components of the lymphatic system. However, unique physiological structure lymph has traditionally constrained drug delivery efficiency. Excitingly, nanomedicines have shown tremendous advantages node-specific delivery, enabling distinct recognition and diagnosis nodes, hence laying foundation for efficient therapies. In this review, we comprehensively discuss factors affecting specific enrichment systematically summarize precise node therapeutic application, including treatment nanodrugs imaging identification Notably, delve into critical challenges considerations currently facing nanomedicines, futher propose effective strategies to address these issues. This review encapsulates recent findings, clinical applications, future prospects designing nanocarriers system targeting, with potential implications improving cancer strategies.

Language: Английский

---

Therapeutic synthetic and natural materials for immunoengineering

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(4), P. 1789 - 1822

Published: Jan. 1, 2024

This review discusses the balance of inflammation in immunity and biomaterials strategies to modulate cases imbalance such as autoimmune disease, infection, cancer. Adapted from “Balanced Energy State”, by BioRender.com (2023).

Language: Английский

---

Two-dimensional nanomaterials induced nano-bio interfacial effects and biomedical applications in cancer treatment

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 18, 2024

Abstract Two-dimensional nanomaterials (2D NMs), characterized by a large number of atoms or molecules arranged in one dimension (typically thickness) while having tiny dimensions the other two dimensions, have emerged as pivotal class materials with unique properties. Their flat and sheet-like structure imparts distinctive physical, chemical, electronic attributes, which offers several advantages biomedical applications, including enhanced surface area for efficient drug loading, surface-exposed allowing precise chemical modifications, ability to form hierarchical multilayer structures synergistic functionality. Exploring their nano-bio interfacial interactions biological components holds significant importance comprehensively systematically guiding safe applications. However, current lack in-depth analysis comprehensive understanding effects on cancer treatment motivates our ongoing efforts this field. This study provides survey recent advances utilizing 2D NMs treatment. It insights into structural characteristics, synthesis methods, modifications diverse NMs. The investigation further delves formation interfaces during vivo utilization. Notably, discusses wide array applications With potential revolutionize therapeutic strategies outcomes, are poised at forefront treatment, holding promise transformative advancements. Graphical

Language: Английский

---

β-glucan-modified nanoparticles with different particle sizes exhibit different lymphatic targeting efficiencies and adjuvant effects

Journal of Pharmaceutical Analysis, Journal Year: 2024, Volume and Issue: 14(12), P. 100953 - 100953

Published: Feb. 23, 2024

Particle size and surface properties are crucial for lymphatic drainage (LN), dendritic cell (DC) uptake, DC maturation, antigen cross-presentation induced by nanovaccine injection, which lead to an effective cell-mediated immune response. However, the manner in particle of vaccine carriers such as mesoporous silica nanoparticles (MSNs) affect this response is unknown. We prepared 50, 100, 200 nm MSNs that adsorbed ovalbumin (OVA) while modifying β-glucan enhance immunogenicity. The results revealed these with different sizes were just efficient vitro, modification demonstrated higher efficacy. vivo indicated smaller have stronger targeting efficiency a greater ability promote maturation DCs. also indicate β-glucan-modified MSN, ∼100 nm, has great potential delivery vehicle adjuvant offers novel approach multiple therapeutic agents target other lymph-mediated diseases.

Language: Английский

---

A next-generation STING agonist MSA-2: From mechanism to application

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 371, P. 273 - 287

Published: June 1, 2024

Language: Английский

---