Near-infrared (NIR) fluorescence-emitting small organic molecules for cancer imaging and therapy

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(21), P. 8957 - 9008

Published: Jan. 1, 2022

We discuss recent advances made in the development of NIR fluorescence-emitting small organic molecules for tumor imaging and therapy.

Language: Английский

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Recent progress in the development of fluorescent probes for imaging pathological oxidative stress

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(11), P. 3873 - 3926

Published: Jan. 1, 2023

Oxidative stress is closely related to the physiopathology of numerous diseases. Reactive oxygen species (ROS), reactive nitrogen (RNS), and sulfur (RSS) are direct participants important biomarkers oxidative stress.

Language: Английский

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Activity-based fluorescence probes for pathophysiological peroxynitrite fluxes

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 454, P. 214356 - 214356

Published: Dec. 14, 2021

Language: Английский

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An Activity‐Based Fluorescent Probe for Imaging Fluctuations of Peroxynitrite (ONOO⁻) in the Alzheimer's Disease Brain

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(36)

Published: July 5, 2022

Abstract Peroxynitrite (ONOO − ) plays a critical role in Alzheimer's disease (AD). To reveal the ONOO influx AD brains, an activatable activity‐based fluorescence probe Rd‐DPA3 was designed by structure‐modulated strategy. Taking advantage of ‐initiated two‐step cascade reactions novel chemical trigger, specifically responds to 0.3 mM other reactive oxygen species (ROS) and varied proteins, gives intensive enhancement ( F / 0 =50). Moreover, with its mitochondria‐targeting ability, can be used efficiently monitor alternations intracellular levels cerebral cells during oxidative stress. Significantly, due NIR emission good blood–brain barrier (BBB) crossing is suitable for vivo imaging illustrating age‐dependent accumulation mice brains.

Language: Английский

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Near infrared fluorescent probes for detecting and imaging active small molecules

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 482, P. 215080 - 215080

Published: Feb. 21, 2023

Language: Английский

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Engineering of BODIPY-based theranostics for cancer therapy

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 476, P. 214908 - 214908

Published: Nov. 7, 2022

Language: Английский

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Multifunctional Fluorescent Probe for Simultaneous Detection of ONOO^–, Viscosity, and Polarity and Its Application in Ferroptosis and Cancer Models

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(13), P. 5780 - 5787

Published: March 20, 2023

Intracellular peroxynitrite anions (ONOO-) and microenvironments (such as viscosity polarity) play an important role in maintaining redox homeostasis, regulating diffusion, transportation, signal transduction living cells. The abnormality of these factors is often closely related to various physiological/pathological processes. However, owing the lack suitable probes, simultaneous visualization ONOO-, viscosity, polarity ferroptosis cancer models has not been achieved. To meet urgent needs, we presented a multifunctional near-infrared (NIR) fluorescent probe, named MQA-P, for simultaneously detecting within mitochondria. probe exhibited remarkable turn-on response ONOO- with far-red emission about 645 nm was highly sensitive viscosity/polarity NIR channel λem > 704 nm. Facilitated by first time, revealed that erastin-induced accompanied significant upregulation increase (or decrease at same time. Moreover, concurrent use diagnosis successfully achieved only cell/tissue levels but also tumor mice models. Compared one factor, this detection multimarkers provides more reliable method/tool tracking ferroptosis-related pathological processes diagnosis, holding great potential preclinical research, medical imaging-guided surgery.

Language: Английский

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A HClO-activated BODIPY based ratiometric fluorescent probe with dual near-infrared channels for differentiating cancerous cells from normal cells and surgical guidance of tumor resection

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: 275, P. 117247 - 117247

Published: Feb. 7, 2025

Language: Английский

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Highly Sensitive Near-Infrared Imaging of Peroxynitrite Fluxes in Inflammation Progress

Analytical Chemistry, Journal Year: 2021, Volume and Issue: 93(5), P. 3035 - 3041

Published: Jan. 25, 2021

Inflammation is an important protection reaction in living organisms associated with many diseases. Since peroxynitrite (ONOO–) engaged the inflammatory processes, illustrating key nexus between ONOO– and inflammation significant. Due to lack of sensitive vivo detection methods, research still remains at its infancy. Herein, a highly NIR fluorescence probe DDAO-PN for progress was reported. The responded significant enhancement 657 nm (84-fold) within 30 s solution. Intracellular imaging exogenous demonstrated 68-fold increase (F/F0). Impressively, can detect fluxes LPS-induced rear leg 4.0-fold peritonitis 8.0-fold remarkable quick response enabled real-time tracking large signal-to-noise (S/N) ratio. These results clearly denoted that able be high-fidelity high sensitivity will boost inflammation-related

Language: Английский

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One probe for multiple targets: A NIR fluorescent rhodamine-based probe for ONOO− and lysosomal pH detection in live cells

Sensors and Actuators B Chemical, Journal Year: 2021, Volume and Issue: 337, P. 129732 - 129732

Published: March 14, 2021

Language: Английский

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