ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
17(1), P. 725 - 738
Published: Dec. 16, 2024
Targeting
tumor
markers
is
one
of
the
most
important
approaches
to
therapy,
and
"suicide"
pattern
marker
response
a
very
challenging
study.
Telomerase,
as
key
factors
associated
with
human
longevity
cancer
progression,
considered
be
an
emerging
biomarker
for
diagnosis.
The
targeted
drug
delivery
nanobomb─BIBR1532@HSN/FQDNA/MUC1
aptamer
(B@HDA)
prepared
in
this
study
based
on
hollow
silica
nanoparticles
(HSN)
CRISPR
systems.
Amino-modified
FQDNA
amino-modified
MUC1
are
covalently
attached
surface
carboxyl-functionalized
HSN.
modified
directs
nanobomb
specifically
target
breast
cells
(MCF-7)
sequesters
telomerase
inhibitor
(BIBR1532)
within
Telomerase
primers
(TPs)
recognized
by
highly
expressed
MCF-7
elongated
form
DNA
substrates.
substrate
pairs
crRNA
bases
effectively
activate
CRISPR-Cas12a.
activated
CRISPR-Cas12a
precisely
cut
FQDNA,
releasing
BIBR1532,
which
inhibits
activity.
This
strategy
achieves
"suicide".
described
above
has
following
advantages.
(1)
"closing"
effect
contributes
reducing
nonspecific
release
BIBR1532.
(2)
B@HDA,
combined
CRISPR,
regulates
mitochondrial
dysfunction
cell
senescence
cells.
(3)
In
tumor-bearing
mouse
model,
exhibits
good
biocompatibility
obvious
ablation
tumors,
suggesting
potential
application
prospects
across
wide
range
lines.
summary,
proposed
provides
tunable
switch
approach
specific
inhibition
reduction
growth,
representing
promising
avenue
promoting
treating
cancer.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(5), P. 1168 - 1168
Published: March 6, 2024
Many
important
biological
species
have
been
identified
as
cancer
biomarkers
and
are
gradually
becoming
reliable
targets
for
early
diagnosis
late
therapeutic
evaluation
of
cancer.
However,
accurate
quantitative
detection
remains
challenging
due
to
the
complexity
systems
diversity
development.
Fluorescent
probes
extensively
utilized
identifying
substances
their
notable
benefits
being
non-invasive,
quickly
responsive,
highly
sensitive
selective,
allowing
real-time
visualization,
easily
modifiable.
This
review
critiques
fluorescent
used
detecting
imaging
over
last
five
years.
Focuses
made
on
design
strategies
small-molecule
nano-sized
probes,
construction
methods
fluorescence
sensing
platforms,
further
applications
in
multiple
biomarkers,
including
enzymes,
reactive
oxygen
species,
sulfur
microenvironments.
aims
guide
development
excellent
diagnostic
promote
broad
application
analysis
diagnosis.
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(7), P. 7345 - 7354
Published: April 4, 2024
Starvation
therapy
mediated
by
glucose
oxidase
is
a
widely
used
therapeutic
approach
for
tumor
treatment,
but
it
limited
the
simultaneous
drawbacks
of
weak
efficacy,
nonspecificity,
and
systemic
toxicity.
Thus,
combination
was
to
complement
strategy
anticancer
therapy.
On
basis
starvation
therapy,
we
designed
catalytic
model
nanosheets
with
biological
cascade
enzymes
synergizing
drugs.
In
short,
two
(glucose
horseradish
peroxidase)
are
covalently
immobilized
on
Ti3C2
MXene
nanosheet
enzyme
nanoreactor
formed
electrostatically
adsorbing
positive
charged
DOX.
Finally,
outer
layer
coated
hyaluronic
acid.
By
combining
oxidase-mediated
photothermal
chemotherapy,
have
achieved
effect
"killing
three
birds
one
stone"
dual
stimulation
response
endogenous
exogenous
sources
site.
This
method
not
only
achieves
targeting
cancer
cells
also
improves
toxicity
reduced
efficacy
realizes
synergistic
enhanced
reactions.
It
opens
up
new
path
research
nanomedicine.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 10, 2025
Abstract
Cuproptosis
is
a
newly
discovered
copper‐dependent
form
of
cell
death.
Intracellular
glutathione
(GSH)
acts
as
copper
chelator
to
inhibit
cuproptosis,
so
the
reduction
GSH
concentration
conducive
enhancing
cuproptosis
cells.
In
order
reduce
content
and
interfere
with
mitochondrial
metabolism,
strategy
based
on
calcium
overload
depletion
enhance
proposed
in
this
study.
Containing
manganese
(Mn)
(Cu)
elements,
CaCO
3
nanoparticles
(NPs)
are
modified
MCF‐7
aptamer
(CaCO
/Mn/Cu@lip‐Apt).
When
entering
cell,
/Mn/Cu@lip‐Apt
decomposed
released
Mn*
(Mn
2+
/Mn
3+
4+
),
Cu
Ca
.
The
high
valence
Mn
ion
can
effectively
consume
produce
which
catalyzed
H
2
O
reactive
oxygen
species
(ROS),
while
reducing
concentration.
production
ROS
promoted
influx
exogenous
large
accumulation
led
intracellular
overload,
resulting
dysfunction
metabolism
disorders.
,
turn
triggered
cuproptosis.
This
showed
excellent
antitumor
effects
provided
new
way
study
disease
treatment.
Analytical Methods,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
In
this
work,
the
proximity
effect
of
engineered
peptide-DNA
conjugate
(PDC)
is
harnessed
to
induce
DNA
cyclization,
enabling
highly
efficient
and
sensitive
detection
furin.
Bioengineering,
Journal Year:
2024,
Volume and Issue:
11(12), P. 1292 - 1292
Published: Dec. 19, 2024
Fluorescence
is
a
remarkable
property
exhibited
by
many
chemical
compounds
and
biomolecules.
has
revolutionized
analytical
biomedical
sciences
due
to
its
wide-ranging
applications
in
diagnostic
tools
of
biological
environmental
importance.
Fluorescent
molecules
are
frequently
employed
drug
delivery,
optical
sensing,
cellular
imaging,
biomarker
discovery.
Cancer
global
challenge
fluorescence
agents
can
function
as
well
monitoring
tools,
both
during
early
tumor
progression
treatment
monitoring.
Many
fluorescent
be
found
their
natural
form,
but
recent
developments
synthetic
chemistry
molecular
biology
have
allowed
us
synthesize
tune
that
would
not
otherwise
exist
nature.
Naturally
derived
generally
more
biocompatible
environmentally
friendly.
They
also
modified
cost-effective
target-specific
ways
with
the
help
tools.
Understanding
unique
structures
photophysical
properties
key
harnessing
full
potential
research.
As
discovery
efforts
require
rigorous
characterization
pharmacokinetics
pharmacodynamics,
fluorescence-based
detection
accelerates
understanding
interactions
via
vitro
vivo
assays.
Herein,
we
provide
review
products
analogs
exhibit
used
probes,
detailing
properties.
We
provided
some
insights
into
relationships
between
Finally,
discussed
science,
mainly
study
cancer
cells
research,
highlighting
pivotal
role
advancing
biomarkers,
cell
biosensing
technologies,
targeting
ligands
diagnosis
tumors.
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY (CHINESE VERSION),
Journal Year:
2024,
Volume and Issue:
52(6), P. 100400 - 100400
Published: May 23, 2024
Targeted
delivery
of
proteins
into
desired
cell
groups
is
crucial
for
disease
therapy
and
cellular
functionalization.
However,
current
methods
face
severe
side
effects
off-target
problems,
making
it
difficult
to
achieve
cell-targeted
protein
delivery.
Herein,
we
developed
a
user-friendly
membrane
fusion
liposome
cancer
Phosphorothioated
DNA-mediated
was
employed
as
an
efficient
transmembrane
approach.
The
phosphorothioated
DNA
capped
with
the
AS1411
aptamer,
which
specifically
recognizes
nucleolar
on
membrane,
enabling
controllable
targeted
cells.
This
system
exhibited
commendable
biocompatibility
ability,
thereby
realizing
highly
effective
inhibition
in
vitro.
vivo
results
further
suggested
that
protein-responsive
offers
new
avenue
biocompatible
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
1(2), P. 124 - 137
Published: June 1, 2024
Reactive
Oxygen
Species
(ROS)
therapy
based
on
metal
ion
catalysis
had
attracted
much
attention
due
to
its
high
selectivity
for
tumour
cells
and
lower
side
effects.
Copper
ions
(Cu2+)
show
great
potential
in
their
efficient
fenton-like
catalysis.
However,
the
accumulation
utilisation
efficiency
of
copper
within
cell
was
limited,
hence
need
delivery
Cu2+
into
cell.
Curcumin
(CUR)
not
only
acted
as
a
ligand
bind
ions,
but
also
an
electron
donor
increase
catalytic
Cu+
enhance
generation
ROS.
Calcium
carbonate
(CaCO3)
nanoparticles
good
biocompatibility,
alleviated
microacidic
environment
tumours
released
calcium
(Ca2+)
trigger
overload
leading
apoptosis.
Therefore,
present
study,
CaCO3
(CRC@lip)
loaded
with
curcumin
were
designed
modified
liposomal
surface
improve
stability
dispersion
vivo.
CRC@lip
generated
higher
activity
by
releasing
Cu2+,
reacting
glutathione
(GSH).
catalyzed
highly
toxic
·OH
radicals
H2O2,
while
property
CUR
further
enhanced
dispersal
nanoparticles.
The
electron-donor
effect
amplified
killing
through
interaction
This
strategy
improved
therapeutic
effect,
may
reduce
effects
traditional
chemotherapeutic
drugs,
providing
new
way
thinking
cancer
treatment.
