The role of cellular reactive oxygen species in cancer chemotherapy

Journal of Experimental & Clinical Cancer Research, Journal Year: 2018, Volume and Issue: 37(1)

Published: Oct. 31, 2018

Most chemotherapeutics elevate intracellular levels of reactive oxygen species (ROS), and many can alter redox-homeostasis cancer cells. It is widely accepted that the anticancer effect these due to induction oxidative stress ROS-mediated cell injury in cancer. However, various new therapeutic approaches targeting ROS have yielded mixed results. Since it impossible quantitatively detect dynamic tumors during after chemotherapy clinical settings, increasing interest apply mathematical modeling techniques predict for understanding complex tumor biology chemotherapy. This review outlines current role cells carcinogenesis chemotherapy, provides a critical analysis methods used quantitative detection discusses application predicting treatment responses. Finally, we provide insights on perspectives future development effective ROS-inducing agents or antioxidants treatment.

Language: Английский

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Fluorescent probes for organelle-targeted bioactive species imaging

Chemical Science, Journal Year: 2019, Volume and Issue: 10(24), P. 6035 - 6071

Published: Jan. 1, 2019

The dynamic fluctuations of bioactive species in living cells are associated with numerous physiological and pathological phenomena. emergence organelle-targeted fluorescent probes has significantly facilitated our understanding on the biological functions these species. This review describes design, applications, challenges potential directions probes.

Language: Английский

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Fluorescent small organic probes for biosensing

Chemical Science, Journal Year: 2021, Volume and Issue: 12(10), P. 3406 - 3426

Published: Jan. 1, 2021

Small-molecule based fluorescent probes are increasingly important for the detection and imaging of biological signaling molecules due to their simplicity, high selectivity sensitivity, whilst being non-invasive, suitable real-time analysis living systems. With this perspective we highlight sensing mechanisms including Förster resonance energy transfer (FRET), intramolecular charge (ICT), photoinduced electron (PeT), excited state proton (ESIPT), aggregation induced emission (AIE) multiple modality fluorescence approaches dual/triple (DSM or TSM). Throughout remaining challenges suggest potential directions development towards improved small-molecule biosensing.

Language: Английский

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Small Molecule as Fluorescent Probes for Monitoring Intracellular Enzymatic Transformations

Chemical Reviews, Journal Year: 2019, Volume and Issue: 119(22), P. 11718 - 11760

Published: Nov. 14, 2019

All cellular processes are the results of synchronized actions several intracellular biochemical pathways. Recent emphasis is to visualize such pathways using appropriate small molecular reagents, dye-labeled proteins, and genetically encoded fluorescent biosensors that produce a luminescence ON response either on selective binding or reacting with an analyte produced through specific biochemical/enzymatic transformation. Studying enzymatic by probing fluorescence as read-out signal expected provide important insights into crucial transformations induced enzyme in its native form. Many studies extended for monitoring under vitro vivo condition. A few recent reports reveal probes even capable quantifying abnormal levels enzymes real-time linked key area clinical diagnostics chemical biology. analysis all helps developing rationale designing purpose-built chemodosimeters well newer reagents studying process quantification respective enzyme. In this review, attempt will be there highlight bioimaging have provided transformations.

Language: Английский

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Activity‐Based Sensing: A Synthetic Methods Approach for Selective Molecular Imaging and Beyond

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 59(33), P. 13734 - 13762

Published: Oct. 12, 2019

Emerging from the origins of supramolecular chemistry and development selective chemical receptors that rely on lock-and-key binding, activity-based sensing (ABS)-which utilizes molecular reactivity rather than recognition for analyte detection-has rapidly grown into a distinct field to investigate production regulation species mediate biological signaling stress pathways, particularly metal ions small molecules. Chemical reactions exploit diverse enable sensitive synthetic methods decipher their contributions within complex living environments. The broad utility this reaction-driven approach facilitates application imaging platforms ranging fluorescence, luminescence, photoacoustic, magnetic resonance, positron emission tomography modalities. ABS are also being expanded other fields, such as drug materials discovery.

Language: Английский

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Upconversion Nanoprobes: Recent Advances in Sensing Applications

Analytical Chemistry, Journal Year: 2018, Volume and Issue: 91(1), P. 548 - 568

Published: Sept. 27, 2018

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTUpconversion Nanoprobes: Recent Advances in Sensing ApplicationsZhiming ZhangZhiming ZhangSchool of Environmental and Chemical Engineering, Shanghai University, 99 Shangda Road, 200444, Shanghai, ChinaMore by Zhiming ZhangView Biography, Swati ShikhaSwati ShikhaDepartment Biomedical Faculty National University Singapore, Singapore 117583, SingaporeMore ShikhaView Jinliang LiuJinliang LiuSchool LiuView Jing Zhang*Jing China*E-mail: [email protected]More Qingsong Mei*Qingsong MeiDepartment Singapore*E-mail: MeiView Biographyhttp://orcid.org/0000-0003-4327-6931, Yong Zhang*Yong ZhangDepartment Biographyhttp://orcid.org/0000-0002-1303-0458Cite this: Anal. Chem. 2019, 91, 1, 548–568Publication Date (Web):September 27, 2018Publication History Published online27 September 2018Published inissue 2 January 2019https://pubs.acs.org/doi/10.1021/acs.analchem.8b04049https://doi.org/10.1021/acs.analchem.8b04049review-articleACS PublicationsCopyright © 2018 American SocietyRequest reuse permissionsArticle Views6801Altmetric-Citations198LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence for given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Assays,Fluorescence,Ions,Luminescence,Nanoprobes Get e-Alerts

Language: Английский

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A Dual-Response Fluorescent Probe for the Detection of Viscosity and H₂S and Its Application in Studying Their Cross-Talk Influence in Mitochondria

Analytical Chemistry, Journal Year: 2018, Volume and Issue: 90(15), P. 9418 - 9425

Published: July 5, 2018

Intracellular viscosity is an essential microenvironmental parameter and H2S a critical gaseous signaling molecule, which are both related to various physiological processes. It reported that the change of imbalance production in mitochondria associated with overexpression amyloid betapeptide (Aβ), thought play central role pathogenesis Alzheimer's disease (AD). However, our best knowledge, no fluorescent probe found for dual detection mitochondrial H2S. Herein, dual-response (Mito-VS) designed synthesized monitor level H2S, respectively. Mito-VS itself nonfluorescent due free intramolecular rotation between dimethylaniline pyridine. After increase viscosity, prohibited intense red fluorescence released. Upon addition can react form compound 3 strong green be observed. Moreover, possesses good mitochondrion-targeting ability applied imaging on channel visualizing variation exogenous endogenous concentration mitochondria. Most importantly, capable studying cross-talk influence mitochondria, very beneficial knowing AD.

Language: Английский

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Simultaneous Visualization of Endogenous Homocysteine, Cysteine, Glutathione, and their Transformation through Different Fluorescence Channels

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 58(14), P. 4557 - 4561

Published: Feb. 11, 2019

Abstract Studying numerous biologically important species simultaneously is crucial to understanding cellular functions and the root causes of related diseases. Direct visualization endogenous biothiols in biological systems great value their roles. Herein, a novel multi‐signal fluorescent probe was rationally designed exploited for simultaneous sensing homocysteine (Hcy), cysteine (Cys), glutathione (GSH) using different emission channels. This successfully applied discrimination between Hcy, Cys, GSH, transformation living cells.

Language: Английский

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Boosting Cancer Therapy with Organelle-Targeted Nanomaterials

ACS Applied Materials & Interfaces, Journal Year: 2019, Volume and Issue: 11(30), P. 26529 - 26558

Published: May 28, 2019

The ultimate goal of cancer therapy is to eliminate malignant tumors while causing no damage normal tissues. In the past decades, numerous nanoagents have been employed for treatment because their unique properties over traditional molecular drugs. However, lack selectivity and unwanted therapeutic outcomes severely limited index nanodrugs. Recently, a series nanomaterials that can accumulate in specific organelles (nucleus, mitochondrion, endoplasmic reticulum, lysosome, Golgi apparatus) within cells received increasing interest. These rationally designed either directly destroy subcellular structures or effectively deliver drugs into proper targets, which further activate certain cell death pathways, enabling them boost efficiency, lower drug dosage, reduce side effects, avoid multidrug resistance, prevent recurrence. this Review, design principles, targeting strategies, mechanisms, current challenges, potential future directions organelle-targeted will be introduced.

Language: Английский

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Recent developments of BODIPY-based colorimetric and fluorescent probes for the detection of reactive oxygen/nitrogen species and cancer diagnosis

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 439, P. 213936 - 213936

Published: April 16, 2021

Language: Английский

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