Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(7), P. 852 - 852
Published: June 25, 2024
The
disadvantages
of
some
conventional
drugs,
including
their
low
bioavailability,
poor
targeting
efficiency,
and
important
side
effects,
have
led
to
the
rational
design
drug
delivery
systems.
In
particular,
introduction
systems
is
a
potential
approach
enhance
uptake
therapeutic
agents
deliver
them
at
right
time
in
amount
concentration
required
site,
as
well
open
new
strategies
for
effective
illness
treatment.
this
review,
we
provide
basic
understanding
with
an
emphasis
on
use
cyclodextrin-,
polymer-
surfactant-based
These
are
very
attractive
because
they
biocompatible
biodegradable
nanomaterials
multifunctional
components.
We
also
details
considerations
variety
medical
applications
by
employing
several
routes
administration.
International Journal of Nanomedicine,
Journal Year:
2021,
Volume and Issue:
Volume 16, P. 5831 - 5867
Published: Aug. 1, 2021
Abstract:
Around
the
globe,
surges
of
bacterial
diseases
are
causing
serious
health
threats
and
related
concerns.
Recently,
metal
ion
release
photodynamic
photothermal
effects
nanomaterials
were
demonstrated
to
have
substantial
efficiency
in
eliminating
resistance
bacteria.
Nanomaterials
with
characteristics
such
as
surface
plasmonic
resonance,
photocatalysis,
structural
complexities,
optical
features
been
utilized
control
release,
generate
reactive
oxygen
species,
produce
heat
for
antibacterial
applications.
The
superior
present
an
opportunity
explore
enhance
their
activities
leading
clinical
In
this
review,
we
comprehensively
list
three
different
mechanisms
therapy,
therapy
based
on
nanomaterials.
These
divided
into
respective
subgroups
accordance
recent
achievements,
showcasing
prospective
challenges
opportunities
clinical,
environmental,
fields.
Keywords:
nanomaterials,
ions,
photodynamic,
photothermal,
mechanism,
species
Graphical
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(13)
Published: Feb. 27, 2022
Infections
are
regarded
as
the
most
severe
complication
associated
with
human
health,
which
urgent
to
be
solved.
Stimuli-responsive
materials
appealing
therapeutic
platforms
for
antibacterial
treatments,
provide
great
potential
accurate
theranostics.
In
this
review,
advantages,
response
mechanisms,
and
key
design
principles
of
stimuli-responsive
highlighted.
The
biomedical
applications,
current
challenges,
future
directions
also
discussed.
First,
categories
comprehensively
itemized
based
on
different
sources
stimuli,
including
external
physical
environmental
stimuli
(e.g.,
temperature,
light,
electricity,
salt,
etc.)
bacterial
metabolites
acid,
enzyme,
redox,
etc.).
Second,
structural
characteristics,
principles,
applications
responsive
discussed,
underlying
interrelationships
revealed.
molecular
structures
closely
related
stimuli.
Finally,
challenging
issues
proposed.
This
review
will
scientific
guidance
promote
clinical
materials.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(7), P. 11136 - 11151
Published: June 24, 2022
Low-temperature
photothermal
therapy
(PTT)
systems
constructed
by
integrating
organic
agents
with
other
bactericidal
components
that
initiate
bacterial
apoptosis
at
low
hyperthermia
possess
a
promising
prospect.
However,
these
multicomponent
low-temperature
PTT
nanoplatforms
have
drawbacks
in
terms
of
the
tedious
construction
process,
suboptimal
synergy
effect
diverse
antibacterial
therapies,
and
high
laser
dose
needed,
compromising
their
biosafety
ocular
infection
treatment.
Herein,
mild
nanotherapeutic
platform
is
formulated
via
self-assembly
pH-responsive
phenothiazinium
dye.
These
nanoparticles
conversion
efficiency
up
to
84.5%
necessitate
only
an
ultralow
light
36
J/cm2
achieve
efficient
inhibition
pH
5.5
under
650
nm
irradiation.
In
addition,
this
intelligent
nanoplatform
undergoes
negative
positive
charge
reversion
acid
biofilms,
exhibiting
good
penetration
highly
elimination
drug-resistant
E.
coli
biofilms
photoirradiation.
Further
vivo
animal
tests
demonstrated
inflammatory
mitigation
as
well
superior
biocompatibility
Overall,
single-component
system
featuring
simple
processes
holds
great
potential
for
wide
application
clinical
transformation.
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Aug. 23, 2023
Safe
and
efficient
antibacterial
materials
are
urgently
needed
to
combat
drug-resistant
bacteria
biofilm-associated
infections.
The
rational
design
of
nanoparticles
for
flexible
elimination
biofilms
remains
challenging.
Herein,
we
propose
the
fabrication
Janus-structured
targeting
extracellular
polymeric
substance
achieve
dispersion
or
near-infrared
(NIR)
light-activated
photothermal
biofilms,
respectively.
Asymmetrical
dextran-bismuth
selenide
(Dex-BSe)
fabricated
exploit
synergistic
effects
both
components.
Interestingly,
Janus
Dex-BSe
realize
enhanced
dispersal
over
time.
Alternatively,
taking
advantage
preferential
accumulation
at
infection
sites,
self-propelled
active
motion
induced
by
unique
structure
enhances
killing
effect.
application
biofilm
removal
NIR-triggered
eradication
in
vivo
is
demonstrated
Staphylococcus
aureus-infected
mouse
excisional
wound
model
abscess
model,
developed
nanoplatform
holds
great
promise
diverse
scenarios.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
124(2), P. 554 - 628
Published: Nov. 22, 2023
In
vivo
imaging
technologies
have
emerged
as
a
powerful
tool
for
both
fundamental
research
and
clinical
practice.
particular,
luminescence
in
the
tissue-transparent
near-infrared
(NIR,
700–1700
nm)
region
offers
tremendous
potential
visualizing
biological
architectures
pathophysiological
events
living
subjects
with
deep
tissue
penetration
high
contrast
owing
to
reduced
light–tissue
interactions
of
absorption,
scattering,
autofluorescence.
The
distinctive
quantum
effects
nanocrystals
been
harnessed
achieve
exceptional
photophysical
properties,
establishing
them
promising
category
luminescent
probes.
this
comprehensive
review,
between
light
tissues,
well
advantages
NIR
imaging,
are
initially
elaborated.
Subsequently,
we
focus
on
achieving
improved
by
optimizing
performance
nanocrystal
fluorophores.
ingenious
design
strategies
probes
discussed,
along
their
respective
biomedical
applications
versatile
modalities.
Finally,
thought-provoking
reflections
challenges
prospects
future
translation
nanocrystal-based
wisely
provided.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(8), P. 2054 - 2069
Published: Jan. 1, 2024
Microporous
organic
polymers
(MOPs)
and
metal
oxide
hybrid
composites
are
considered
valuable
coating
materials
because
of
their
versatility
derived
from
the
synergistic
combination
MOPs'
inherent
dispersibility
distinctive
properties
oxides.
In
this
study,
we
present
synthesis
sea-urchin-like
MOPs
hybridised
with
silver
nanoparticles
(Ag
