Carbon Dots in Bioimaging, Biosensing and Therapeutics: A Comprehensive Review

Small Science, Journal Year: 2022, Volume and Issue: 2(6)

Published: May 8, 2022

Carbon dots (CDs), comprising crystalline graphitized carbon cores and polymer surface groups, are currently attracting a lot of interest in biological fields owing to their fluorescent properties, high photostability, biocompatibility low toxicity. In addition, the easy preparation functionalization CDs stimulate development CDs‐based composite materials with specific functions. Presently, applications growing at remarkable speed, justifying need for up‐to‐date review articles that capture recent progress this blossoming field. review, breakthroughs synthesis, modification, optical toxicology biocatalytic platforms described. Further, research related bioimaging, biosensing, drug delivery, antibacterial, anticancer (photothermal therapy, photodynamic therapy synergistic therapy) antiviral therapies involving discussed detail. Finally, perspective on prospects challenges biomedicine biotechnology is provided.

Language: Английский

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Understanding bacterial biofilms: From definition to treatment strategies

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: April 6, 2023

Bacterial biofilms are complex microbial communities encased in extracellular polymeric substances. Their formation is a multi-step process. Biofilms significant problem treating bacterial infections and one of the main reasons for persistence infections. They can exhibit increased resistance to classical antibiotics cause disease through device-related non-device (tissue) -associated infections, posing severe threat global health issues. Therefore, early detection search new alternative treatments essential suppressing biofilm-associated In this paper, we systematically reviewed biofilms, associated methods, potential treatment strategies, aiming provide researchers with latest progress biofilms.

Language: Английский

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Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Feb. 21, 2024

Abstract Inflammation-associated diseases encompass a range of infectious and non-infectious inflammatory diseases, which continuously pose one the most serious threats to human health, attributed factors such as emergence new pathogens, increasing drug resistance, changes in living environments lifestyles, aging population. Despite rapid advancements mechanistic research development for these current treatments often have limited efficacy notable side effects, necessitating more effective targeted anti-inflammatory therapies. In recent years, nanotechnology has provided crucial technological support prevention, treatment, detection inflammation-associated diseases. Various types nanoparticles (NPs) play significant roles, serving vaccine vehicles enhance immunogenicity carriers improve targeting bioavailability. NPs can also directly combat pathogens inflammation. addition, facilitated biosensors pathogen imaging techniques This review categorizes characterizes different NPs, summarizes their applications It discusses challenges associated with clinical translation this field explores latest developments prospects. conclusion, opens up possibilities comprehensive management

Language: Английский

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Novel nano-encapsulated probiotic agents: Encapsulate materials, delivery, and encapsulation systems

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 349, P. 184 - 205

Published: July 8, 2022

Language: Английский

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Recent Nanotechnologies to Overcome the Bacterial Biofilm Matrix Barriers

Small, Journal Year: 2022, Volume and Issue: 19(6)

Published: Dec. 5, 2022

Abstract Bacterial biofilm‐related infectious diseases severely influence human health. Under typical situations, pathogens can colonize inert or biological surfaces and form biofilms. Biofilms are functional aggregates that coat bacteria with extracellular polymeric substances (EPS). The main reason for the failure of biofilm infection treatment is low permeability enrichment therapeutic agents within biofilm, which results from particular features matrix barriers such as negatively charged components highly viscous compact EPS structures. Hence, developing novel strategies enhanced penetrability crucial. Herein, current progress nanotechnology methods to improve agents’ against matrix, regulating material morphology surface properties, utilizing physical penetration nano/micromotors microneedle patches, equipping nanoparticles degradation enzymes signal molecules, first summarized. Finally, challenges, perspectives, future implementations engineered delivery systems manage infections presented in detail.

Language: Английский

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Targeting and arginine-driven synergizing photodynamic therapy with nutritional immunotherapy nanosystems for combating MRSA biofilms

Science Advances, Journal Year: 2023, Volume and Issue: 9(28)

Published: July 14, 2023

The resistance and immune escape of methicillin-resistant Staphylococcus aureus (MRSA) biofilms cause recalcitrant infections. Here, we design a targeting synergizing cascade PDT with nutritional immunotherapy nanosystems (Arg-PCN@Gel) containing PCN-224 as platform for providing reactive oxygen species (ROS), incorporating arginine (Arg) nitric oxide (NO) donor to ROS produce more lethal ONOO − promote response, coating gelatin agent persistent Arg provider. adhered the autolysin MRSA inhibited metabolism by down-regulating icdA icaA . It suppressed polysaccharide intercellular adhesin extracellular DNA synthesis prevent biofilm formation. NO broke mature helped penetrate into inactivate internal MRSA. Arg-PCN@Gel drove enhance immunity via inducible synthase/NO axis arginase/polyamine achieve efficient target treatment in cascading synergized provide an effective promising strategy biofilm-associated

Language: Английский

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Mechanisms of antibiotic resistance in Pseudomonas aeruginosa biofilms

Biofilm, Journal Year: 2023, Volume and Issue: 5, P. 100129 - 100129

Published: May 2, 2023

Pseudomonas aeruginosa is a major cause of life-threatening acute infections and life-long lasting chronic infections. The characteristic biofilm mode life in P. severely limits the efficacy antimicrobial therapies, as it leads to intrinsic tolerance, involving physical physiological factors addition biofilm-specific genes that can confer transient protection against antibiotics promoting development resistance. Indeed, striking feature this pathogen extraordinary capacity develop resistance nearly all available through selection chromosomal mutations, evidenced by its outstanding versatile mutational resistome. This threat dramatically amplified infections, driven frequent emergence mutator variants with enhanced spontaneous mutation rates. Thus, mini review focused on describing complex interplay antibiotic mechanisms biofilms, provide potentially useful information for design effective therapeutic strategies.

Language: Английский

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Synergistic anti-biofilm strategy based on essential oils and its application in the food industry

World Journal of Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 41(3)

Published: Feb. 27, 2025

Language: Английский

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Progress and prospects of nanomaterials against resistant bacteria

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 351, P. 301 - 323

Published: Sept. 23, 2022

Language: Английский

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Advancements in antimicrobial nanoscale materials and self-assembling systems

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(20), P. 8696 - 8755

Published: Jan. 1, 2022

Antimicrobial resistance is directly responsible for more deaths per year than either HIV/AIDS or malaria and predicted to incur a cumulative societal financial burden of at least $100 trillion between 2014 2050.

Language: Английский

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