Chitosan-Silica Modified Bio-Nanocomposites: Biocompatible pH-Responsive Nanocarriers for Controlled Doxorubicin Release in Leukemia Treatment DOI

Mo Chen,

Danhui Chen,

Guanyu Li

et al.

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 30, 2024

Language: Английский

Dual antibody-guided drug delivery systems using MOF-PQDs nanocomposites for precise tumor diagnosis and combination therapy DOI
Xu Han, Jia Chen, Yangjing Zhao

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 505, P. 159275 - 159275

Published: Jan. 5, 2025

Language: Английский

Citations

1
Rapid synthesis of CuTA/Cur@ZIF-8 multifunctional drug delivery system towards cancer treatment DOI
Luan Minh Nguyen,

Giao Thuy-Quynh Vu,

Thi‐Kim‐Chi Huynh

et al.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: unknown, P. 136321 - 136321

Published: Feb. 1, 2025

Language: Английский

Citations

1
Rational Design of Metal–Organic Frameworks for Pancreatic Cancer Therapy: from Machine Learning Screening to In Vivo Efficacy DOI Creative Commons
Francesca Melle, Dhruv Menon, João Conniot

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

Abstract Despite improvements in cancer survival rates, metastatic and surgery‐resistant cancers, such as pancreatic cancer, remain challenging, with poor prognoses limited treatment options. Enhancing drug bioavailability tumors, while minimizing off‐target effects, is crucial. Metal–organic frameworks (MOFs) have emerged promising delivery vehicles owing to their high loading capacity, biocompatibility, functional tunability. However, the vast chemical diversity of MOFs complicates rational design biocompatible materials. This study employed machine learning molecular simulations identify suitable for encapsulating gemcitabine, paclitaxel, SN‐38, identified PCN‐222 an optimal candidate. Following loading, MOF formulations are improved colloidal stability biocompatibility. In vitro studies on cell lines shown cellular internalization, delayed release. Long‐term tests demonstrated a consistent performance over 12 months. vivo tumor‐bearing mice revealed that paclitaxel‐loaded PCN‐222, particularly hydrogel local administration, significantly reduced spread tumor growth compared free drug. These findings underscore potential effective system hard‐to‐treat cancers.

Language: Английский

Citations

1
Hybrid Nanoplatforms Based on Photosensitizers and Metal/Covalent Organic Frameworks for Improved Cancer Synergistic Treatment Nano-Delivery Systems DOI Creative Commons

Aviwe Magadla

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 884 - 884

Published: Feb. 14, 2025

Researchers have extensively investigated photosensitizer (PS) derivatives for various applications due to their superior photophysical and electrochemical properties. However, inherent problems, such as instability self-quenching under physiological conditions, limit biological applications. Metal-organic frameworks (MOFs) covalent organic (COFs) represent two relatively new material types. These materials high surface areas permanent porosity, they show a tremendous deal of potential like these. This review summarizes key synthesis processes highlights recent advancements in integrating PS-based COF MOF nanocarriers biomedical while addressing obstacles prospects.

Language: Английский

Citations

1
Toward the Integration of Machine Learning and Molecular Modeling for Designing Drug Delivery Nanocarriers DOI

Xuejiao J. Gao,

Krzesimir Ciura,

Yuanjie Ma

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Abstract The pioneering work on liposomes in the 1960s and subsequent research controlled drug release systems significantly advances development of nanocarriers (NCs) for delivery. This field is evolved to include a diverse array such as liposomes, polymeric nanoparticles, dendrimers, more, each tailored specific therapeutic applications. Despite significant achievements, clinical translation limited, primarily due low efficiency delivery an incomplete understanding nanocarrier interactions with biological systems. Addressing these challenges requires interdisciplinary collaboration deep nano‐bio interface. To enhance design, scientists employ both physics‐based data‐driven models. Physics‐based models provide detailed insights into chemical reactions at atomic molecular scales, while leverage machine learning analyze large datasets uncover hidden mechanisms. integration presents harmonizing different modeling approaches ensuring model validation generalization across However, this crucial developing effective targeted By integrating enhanced data infrastructure, explainable AI, computational advances, potentials, researchers can develop innovative nanomedicine solutions, ultimately improving outcomes.

Language: Английский

Citations

8
Transformation of metal-organic frameworks (MOFs) under different factors DOI

Yilei Xiang,

Suosu Wei,

Taoxiang Wang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 523, P. 216263 - 216263

Published: Oct. 21, 2024

Language: Английский

Citations

7
Elucidation of the CO2 adsorption mechanism of [Zn2(mtz)2(ox)] using neutron powder diffraction DOI
Lingxiang Bao, Jing‐Hong Li, Rui‐Biao Lin

et al.

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 110864 - 110864

Published: Jan. 1, 2025

Language: Английский

Citations

0
Polyvalent DNA Patches Enable Metal–Organic Fameworks with Enhanced Structural Integrity, Biointerface Stability, and Cellular Uptake DOI
Zhaoyu Han,

Haozhen Yu,

Biwu Liu

et al.

Chemistry of Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 18, 2025

Language: Английский

Citations

0
Thermo- and pH-responsive MOF-303 mediated P127 and Gelatin coating for combination drug release and liver cancer therapy DOI
Sat Septian Dwitya,

Kuen-Song Lin,

Meng‐Tzu Weng

et al.

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 44, P. 102548 - 102548

Published: Jan. 30, 2025

Language: Английский

Citations

0
Advances in metal-organic framework-based drug delivery systems DOI

M T Khulood,

U. S. Jijith,

Punnoth Poonkuzhi Naseef

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125380 - 125380

Published: Feb. 1, 2025

Language: Английский

Citations

0