Supramolecular Adhesive Hydrogels for Tissue Engineering Applications

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(6), P. 5604 - 5640

Published: Jan. 13, 2022

Tissue engineering is a promising and revolutionary strategy to treat patients who suffer the loss or failure of an organ tissue, with aim restore dysfunctional tissues enhance life expectancy. Supramolecular adhesive hydrogels are emerging as appealing materials for tissue applications owing their favorable attributes such tailorable structure, inherent flexibility, excellent biocompatibility, near-physiological environment, dynamic mechanical strength, particularly attractive self-adhesiveness. In this review, key design principles various supramolecular strategies construct comprehensively summarized. Thereafter, recent research progress regarding applications, including primarily dermal repair, muscle bone neural vascular oral corneal cardiac fetal membrane hepatic gastric systematically highlighted. Finally, scientific challenges remaining opportunities underlined show full picture hydrogels. This review expected offer comparative views critical insights inspire more advanced studies on pave way different fields even beyond applications.

Language: Английский

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Hydrogel interfaces for merging humans and machines

Nature Reviews Materials, Journal Year: 2022, Volume and Issue: 7(12), P. 935 - 952

Published: Oct. 13, 2022

Language: Английский

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Wound Dressing: From Nanomaterials to Diagnostic Dressings and Healing Evaluations

ACS Nano, Journal Year: 2022, Volume and Issue: 16(2), P. 1708 - 1733

Published: Jan. 20, 2022

Wound dressings based on nanomaterials play a crucial role in wound treatment and are widely used whole range of medical settings, from minor to life-threatening tissue injuries. This article presents an educational review the accumulating knowledge this multidisciplinary area lay out challenges opportunities that lie ahead ignite further faster development clinically valuable technologies. The analyzes functional advantages nanomaterial-based gauzes hydrogels as well hybrid structures thereof. On basis, state-of-the-art advances transfer (semi)blind approaches evaluation state smart enable real-time monitoring diagnostic functions could help during healing. explores translation related aspects into real-world use. ongoing future associated with clinical decisions presented reviewed.

Language: Английский

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Superstrong, superstiff, and conductive alginate hydrogels

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: May 31, 2022

Abstract For the practical use of synthetic hydrogels as artificial biological tissues, flexible electronics, and conductive membranes, achieving requirements for specific mechanical properties is one most prominent issues. Here, we demonstrate superstrong, superstiff, alginate with densely interconnecting networks implemented via simple reconstructing processes, consisting anisotropic densification pre-gel a subsequent ionic crosslinking rehydration. The reconstructed hydrogel exhibits broad ranges exceptional tensile strengths (8–57 MPa) elastic moduli (94–1,290 depending on ions. This can hold sufficient cations (e.g., Li + ) within its gel matrix without compromising performance high conductivity enough to be utilized electrolyte membrane. Further, this strategy applied prepare mechanically outstanding, ionic-/electrical-conductive by incorporating conducting polymer matrix. Such are easily laminated strong interfacial adhesion superficial de- re-crosslinking resulting layered act stable membrane an aqueous supercapacitor.

Language: Английский

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Bioinspired Injectable Self-Healing Hydrogel Sealant with Fault-Tolerant and Repeated Thermo-Responsive Adhesion for Sutureless Post-Wound-Closure and Wound Healing

Nano-Micro Letters, Journal Year: 2022, Volume and Issue: 14(1)

Published: Sept. 13, 2022

Hydrogels with multifunctionalities, including sufficient bonding strength, injectability and self-healing capacity, responsive-adhesive ability, fault-tolerant repeated tissue adhesion, are urgently demanded for invasive wound closure healing. Motivated by the adhesive mechanism of mussel brown algae, bioinspired dynamic bonds cross-linked multifunctional hydrogel is designed based on sodium alginate (SA), gelatin (GT) protocatechualdehyde, ferric ions added, sutureless post-wound-closure. The through Schiff base bond, catechol-Fe coordinate bond strong interaction between GT temperature-dependent phase transition SA, endows resulting mechanical strength efficient closure, reopened wounds. Moreover, properties endowed mispositioning to be removed/repositioned, which conducive adhesion adhesives during surgery. Besides, hydrogels present good biocompatibility, near-infrared-assisted photothermal antibacterial activity, antioxidation thermo-responsive reversible hemostatic effect. in vivo incision evaluation demonstrated their capability promote post-wound-closure healing incisions, indicating that developed dressing could serve as versatile sealant.

Language: Английский

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Multi-crosslinking hydrogels with robust bio-adhesion and pro-coagulant activity for first-aid hemostasis and infected wound healing

Bioactive Materials, Journal Year: 2022, Volume and Issue: 16, P. 388 - 402

Published: March 9, 2022

Language: Английский

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Emerging Technologies in Multi‐Material Bioprinting

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(49)

Published: Oct. 1, 2021

Bioprinting, within the emerging field of biofabrication, aims at fabrication functional biomimetic constructs. Different 3D bioprinting techniques have been adapted to bioprint cell-laden bioinks. However, single-material oftentimes fail reproduce complex compositions and diversity native tissues. Multi-material as an approach enables heterogeneous multi-cellular constructs that replicate their host microenvironments better than approaches. Here, modalities are reviewed, being multi-material is discussed, advantages challenges, encompassing both custom-designed commercially available technologies analyzed. A perspective how opens up new opportunities for tissue engineering, model therapeutics development, personalized medicine offered.

Language: Английский

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Injectable, self-healing hydrogel adhesives with firm tissue adhesion and on-demand biodegradation for sutureless wound closure

Science Advances, Journal Year: 2023, Volume and Issue: 9(33)

Published: Aug. 16, 2023

Tissue adhesives have garnered extensive interest as alternatives and supplements to sutures, whereas major challenges still remain, including weak tissue adhesion, inadequate biocompatibility, uncontrolled biodegradation. Here, injectable biocompatible hydrogel are developed via catalyst-free o-phthalaldehyde/amine (hydrazide) cross-linking reaction. The hydrogels demonstrate rapid firm adhesion various tissues, an o-phthalaldehyde-mediated mechanism is established. show controlled degradation profiles of 6 22 weeks in vivo through the incorporation disulfide bonds into network. In liver blood vessel injury, effectively seal incisions rapidly stop bleeding. rat rabbit models full-thickness skin incision, quickly close accelerate wound healing, which exhibit efficacies superior those commercially available fibrin glue cyanoacrylate glue. Thus, great potential for sutureless closure, hemostasis sealing, prevention leakage surgical applications.

Language: Английский

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Probing and Manipulating Noncovalent Interactions in Functional Polymeric Systems

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(18), P. 14594 - 14678

Published: Sept. 2, 2022

Noncovalent interactions, which usually feature tunable strength, reversibility, and environmental adaptability, have been recognized as driving forces in a variety of biological chemical processes, contributing to the recognition between molecules, formation molecule clusters, establishment complex structures macromolecules. The marriage noncovalent interactions conventional covalent polymers offers systems novel mechanical, physicochemical, properties, are highly dependent on binding mechanisms that can be illuminated via quantification. This review systematically discusses nanomechanical characterization typical polymeric systems, mainly through direct force measurements at microscopic, nanoscopic, molecular levels, provide quantitative information (e.g., ranges, strengths, dynamics) behaviors. fundamental understandings intermolecular interfacial then correlated macroscopic performances series noncovalently bonded polymers, whose functions stimuli-responsiveness, self-healing capacity, universal adhesiveness) customized manipulation providing insights into rational design advanced materials with applications biomedical, energy, environmental, other engineering fields.

Language: Английский

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Skin-like hydrogel devices for wearable sensing, soft robotics and beyond

iScience, Journal Year: 2021, Volume and Issue: 24(11), P. 103174 - 103174

Published: Sept. 27, 2021

Skin-like electronics are developing rapidly to realize a variety of applications such as wearable sensing and soft robotics. Hydrogels, biomaterials, have been studied intensively for skin-like electronic utilities due their unique features softness, wetness, biocompatibility ionic capability. These could potentially blur the gap between biological systems hard artificial machines. However, development hydrogel devices is still in its infancy faces challenges including limited functionality, low ambient stability, poor surface adhesion, relatively high power consumption (as sensors). This review aims summarize current skin-inspired address these challenges. We first conduct an overview hydrogels existing strategies increase toughness conductivity. Next, we describe approaches leverage with advanced merits anti-dehydration, anti-freezing, adhesion. Thereafter, highlight state-of-the-art electronics, robotics, energy harvesting. Finally, conclude outline future trends.

Language: Английский

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