Personal Perspective on Understanding Low Molecular Weight Gels

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(25), P. 11047 - 11053

Published: June 17, 2022

Low molecular weight gels are formed by the self-assembly of small molecules into anisotropic structures that form a network capable immobilizing solvent. Such common, with huge number different examples existing, and they have many applications. However, there still significant gaps in our understanding these systems challenges need to be addressed if we able fully design such systems. Here, discussed.

Language: Английский

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Self-assembly of colloidal metal–organic framework (MOF) particles

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(7), P. 2528 - 2543

Published: Jan. 1, 2023

Self-assembly of colloidal particles into ordered superstructures enables the development novel advanced materials for diverse applications such as photonics, electronics, sensing, energy conversion, storage, diagnosis, drug or gene delivery, and catalysis. Recently, polyhedral metal-organic framework (MOF) have been proposed promising to form superstructures, based on their stability, size-tunability, rich shapes, porosity multifunctionality. In this review, we present a comprehensive overview strategies self-assembly MOF different dimensionalities, highlighting some properties applications, sharing thoughts particles.

Language: Английский

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Physical strategies to engineer supramolecular composite hydrogels for advanced biomedical applications

Progress in Materials Science, Journal Year: 2025, Volume and Issue: 151, P. 101428 - 101428

Published: Jan. 9, 2025

Language: Английский

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Hierarchical Materials from High Information Content Macromolecular Building Blocks: Construction, Dynamic Interventions, and Prediction

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(24), P. 17397 - 17478

Published: Oct. 19, 2022

Hierarchical materials that exhibit order over multiple length scales are ubiquitous in nature. Because hierarchy gives rise to unique properties and functions, many have sought inspiration from nature when designing fabricating hierarchical matter. More more, however, nature's own high-information content building blocks, proteins, peptides, peptidomimetics, being coopted build because the information determines structure, function, interfacial interactions can be readily encoded these versatile macromolecules. Here, we take stock of recent progress rational design characterization produced blocks with a focus on stimuli-responsive "smart" architectures. We also review advances use computational simulations data-driven predictions shed light how side chain chemistry conformational flexibility macromolecular drive emergence acquisition ionic, solvent, surface effects influence outcomes assembly. Continued above areas will ultimately usher an era where understanding designed interactions, effects, solution conditions harnessed achieve predictive synthesis across scale emergent phenomena self-assembly reconfiguration blocks.

Language: Английский

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Subcellular visualization: Organelle-specific targeted drug delivery and discovery

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 199, P. 114977 - 114977

Published: June 28, 2023

Language: Английский

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Four distinct network patterns of supramolecular/polymer composite hydrogels controlled by formation kinetics and interfiber interactions

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: March 27, 2023

Synthetic composite hydrogels comprising supramolecular fibers and covalent polymers have attracted considerable attention because their properties are similar to biological connective tissues. However, an in-depth analysis of the network structures has not been performed. In this study, we discovered can be categorized into four distinct patterns regarding morphology colocalization components using in situ, real-time confocal imaging. Time-lapse imaging formation process reveals that governed by two factors, order interactions between different fibers. Additionally, studies revealed a unique hydrogel undergoing dynamic remodeling on scale hundred micrometers more than one millimeter. Such allow for fracture-induced artificial patterning three dimensionally. This study introduces valuable guideline design hierarchical soft materials.

Language: Английский

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A Close Look at Molecular Self-Assembly with the Transmission Electron Microscope

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(22), P. 14232 - 14280

Published: July 30, 2021

Molecular self-assembly is pervasive in the formation of living and synthetic materials. Knowledge gained from research into principles molecular drives innovation biological, chemical, materials sciences. Self-assembly processes span a wide range temporal spatial domains are often unintuitive complex. Studying such complex requires an arsenal analytical computational tools. Within this arsenal, transmission electron microscope stands out for its unique ability to visualize quantify structures processes. This review describes contribution that has made field self-assembly. An emphasis placed on which TEM methods applicable different how can be used combination with other experimental or methods. Finally, we provide outlook current challenges to, opportunities for, increasing impact have

Language: Английский

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Peptide Self-Assembled Nanostructures: From Models to Therapeutic Peptides

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(3), P. 466 - 466

Published: Jan. 28, 2022

Self-assembly is the most suitable approach to obtaining peptide-based materials on nano- and mesoscopic scales. Applications span from peptide drugs for personalized therapy light harvesting electron conductive media solar energy production bioelectronics, respectively. In this study, we will discuss self-assembly of selected model bioactive peptides, in particular reviewing our recent work formation architectures size solution solid substrates. The hierarchical cooperative characters be highlighted, focusing structural dynamical properties building blocks nature intermolecular interactions driving aggregation phenomena a given environment. These results pave way understanding still-debated mechanism action an antimicrobial (trichogin GA IV) pharmacokinetic drug (semaglutide) currently use type-II diabetes.

Language: Английский

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Self-assembling peptide biomaterials: Insights from spontaneous and enhanced sampling molecular dynamics simulations

Chemical Physics Reviews, Journal Year: 2023, Volume and Issue: 4(2)

Published: April 21, 2023

Peptide self-assembly is the process by which peptide molecules aggregate into low dimensional (1D, 2D) or 3D ordered materials with potential applications ranging from drug delivery to electronics. Short peptides are particularly good candidates for forming supramolecular assemblies due relatively simple structure and ease of modulating their achieve required material properties. The experimental resolution fibrous peptide-based nanomaterials as atomic coordinates remains challenging. For surface-mediated assembly in particular, it typically not feasible resolve multiple conformationally distinct surface bound structures experiment. mechanisms also remain elusive interchange complex interactions time length scales involved process. solution, mediated surfaces, driven specific between water, competing within and/or units and, latter case, an interplay solvent adsorption onto a proximal surface. Computational methodologies have proven beneficial elucidating formed during molecular driving it, hence scope facilitating development functional medical biotechnological applications. In this perspective, computational methods that provided insights formation biomaterials, all-atom-resolved presented. Established recently emerged simulation approaches reviewed focus on relevant assembly, including all-atom coarse-grained “brute force” dynamics well enhanced sampling methodologies: umbrella sampling, steered replica exchange dynamics, variants metadynamics. These been shown contribute details yet available experimentally, advance our understanding processes biomaterial formation. review includes summary current state methods, terms strengths limitations application self-assembling biomaterials.

Language: Английский

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Holotomography and atomic force microscopy: a powerful combination to enhance cancer, microbiology and nanotoxicology research

Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)

Published: April 9, 2024

Modern imaging strategies are paramount to studying living systems such as cells, bacteria, and fungi their response pathogens, toxicants, nanomaterials (NMs) modulated by exposure environmental factors. The need understand the processes mechanisms of damage, healing, cell survivability continues motivate development alternative strategies. Of particular interest is use label-free techniques (microscopy procedures that do not require sample staining) minimize interference biological foreign marking substances reduce intense light potential photo-toxicity effects. This review focuses on synergic capabilities atomic force microscopy (AFM) a well-developed robust strategy with demonstrated applications unravel intimate details in biomedical applications, label-free, fast, enduring Holotomographic Microscopy (HTM) strategy. HTM technique combines holography tomography using low intensity continuous illumination laser investigate (quantitatively non-invasively) microorganisms, thin tissue generating three-dimensional (3D) images monitoring real-time inner morphological changes. We first operating principles form basis for complementary provided these regarding surface internal information AFM, which essential complimentary several areas interaction NMs organisms. First, AFM can provide superb resolution morphology biomechanical characterization. Second, quantitative phase enable modeling quantification volume, area, protein content, mass density main components cells including microbiological systems. These result from directly quantifying refractive index changes without requiring fluorescent markers or chemicals. As such, ideal long-term organisms conditions close natural settings. present case-based principal uses both contributions nanomedicine nanotoxicology (study harmful effects organisms), emphasizing cancer infectious disease control. impact sequential provides clear drive adopting interdependent fundamental tools.

Language: Английский

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