Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 24, 2025
Language: Английский
Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(19), P. 6680 - 6714
Published: Jan. 1, 2023
The quantitative assessment of the greenness mechanochemical processes for green metrics were calculated is herein reported. A general introduction to topic, variables influencing reaction outcome and, an outlook are also provided.
Language: Английский
Citations
95
Green Chemistry, Journal Year: 2022, Volume and Issue: 24(17), P. 6435 - 6449
Published: Jan. 1, 2022
This review highlights the use of Cyrene as an alternative green solvent in organic synthesis.
Language: Английский
Citations
73
Materials Science and Engineering R Reports, Journal Year: 2024, Volume and Issue: 159, P. 100775 - 100775
Published: Feb. 28, 2024
In light of escalating biomedical demands across diverse diseases, there arises a pressing need for the development sophisticated biocompatible materials exhibiting augmented biological functionality. Chitosan, cationic polyelectrolyte copolymer natural origin, distinguishes itself through its extraordinary properties, positioning it as promising starting material to develop versatile materials. Tremendous attention has been directed towards creation high-performance biocomposites, achieved strategic manipulation chitosan's structure or derivative, along with amalgamation other biopolymers. This comprehensive review intricately explores recent advancements in chitosan-based biofunctional materials, delving into formulations involving various biopolymers including polysaccharides and proteins. It places specific emphasis on progress chitosan chemistry development, encompassing particles, hydrogels, aerogels, membranes, films, sponges. Also, this critically evaluates functional properties chitosan–biopolymer composite spotlighting interactions, both dynamic covalent noncovalent, their pivotal roles formation. These interactions may either be inherent realized chemical modification such "Click" chemistry, polymer grafts, mussel-inspired selective oxidation. Furthermore, text illustrates current potential applications these spanning from wound dressing tissue engineering (skin, bone, cartilage, nerve), controlled release targeted delivery drugs/bioactive compounds, biosensing, 3D printing. Additionally, addresses critical challenges within field, posits solutions, provides forward-looking perspective future directions biomaterials design strategies.
Language: Английский
Citations
73
Green Chemistry, Journal Year: 2023, Volume and Issue: 25(6), P. 2109 - 2169
Published: Jan. 1, 2023
Green chemistry has become a hot topic and the focus of not only many companies but also researchers.
Language: Английский
Citations
70
Langmuir, Journal Year: 2024, Volume and Issue: 40(18), P. 9579 - 9591
Published: April 24, 2024
Herein, a fiber-supported iron-based ionic liquid as type of fibrous catalyst has been developed for the synthesis bioactive 3,4-dihydropyrimidin-2-(1H)-ones (DHPMs) via three-component Biginelli reactions in cleaner manner. The described was obtained from commercially available polyetheretherketone (PEEK) fiber by postfunctionalization processes and characterized analyzed detail means diversified technologies. Furthermore, liquids could mediate classical to proceed smoothly gain variety substituted DHPMs with yields up 99%. superior catalytic activities were ascribed quasi-homogeneous medium generated surface layer PEEK fiber, which afford an appropriate reaction zone further be aggregation substrates facilitate reaction. Notably, is recycling over 10 runs just pair tweezers, operational procedure capable enlarging system gram-scale without any performance degradation, provided manner take advantage organic potential industrialization prospects.
Language: Английский
Citations
68
Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: 694, P. 134160 - 134160
Published: May 3, 2024
Language: Английский
Citations
63
ACS Medicinal Chemistry Letters, Journal Year: 2023, Volume and Issue: 14(4), P. 376 - 385
Published: March 8, 2023
The generation of multiple bonds in one reaction step has attracted massive interest drug discovery and development. Multicomponent reactions (MCRs) offer the advantage combining three or more reagents a one-pot fashion to effectively yield synthetic product. This approach significantly accelerates synthesis relevant compounds for biological testing. However, there is perception that this methodology will only produce simple chemical scaffolds with limited use medicinal chemistry. In Microperspective, we want highlight value MCRs toward complex molecules characterized by presence quaternary chiral centers. paper cover specific examples showing impact technology clinical recent breakthroughs expand scope topologically rich molecular chemotypes.
Language: Английский
Citations
49
Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(15), P. 9397 - 9446
Published: July 7, 2023
The proportion of approved chiral drugs and drug candidates under medical studies has surged dramatically over the past two decades. As a consequence, efficient synthesis enantiopure pharmaceuticals or their synthetic intermediates poses profound challenge to medicinal process chemists. significant advancement in asymmetric catalysis provided an effective reliable solution this challenge. successful application transition metal catalysis, organocatalysis, biocatalysis pharmaceutical industries promoted discovery by precise preparation enantio-enriched therapeutic agents, facilitated industrial production active ingredient economic environmentally friendly fashion. present review summarizes most recent applications (2008–2022) industry ranging from scales pilot levels. It also showcases latest achievements trends agents with state art technologies catalysis.
Language: Английский
Citations
45
The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(7), P. 4261 - 4282
Published: March 20, 2024
Small molecule therapeutics represent the majority of FDA-approved drugs. Yet, many attractive targets are poorly tractable by small molecules, generating a need for new therapeutic modalities. Due to their biocompatibility profile and structural versatility, peptide-based possible solution. Additionally, in past two decades, advances peptide design, delivery, formulation, devices have occurred, making peptides an modality. However, manufacturing is often limited solid-phase synthesis (SPPS), liquid phase (LPPS), lesser extent hybrid SPPS/LPPS, with SPPS emerging as predominant platform technology synthesis. involves use excess solvents reagents which negatively impact environment, thus highlighting newer technologies reduce environmental footprint. Herein, fourteen American Chemical Society Green Chemistry Institute Pharmaceutical Roundtable (ACS GCIPR) member companies portfolio compiled Process Mass Intensity (PMI) metrics help inform sustainability efforts This includes PMI assessment on 40 synthetic processes at various development stages pharma, classified according phase. most comprehensive date. The process was divided into (synthesis, purification, isolation) determine respective PMI. On average, (SPPS) (PMI ≈ 13,000) does not compare favorably other modalities such molecules median 168–308) biopharmaceuticals 8300). Thus, high warrants more environmentally friendly manufacturing.
Language: Английский
Citations
33
Green Chemistry, Journal Year: 2024, Volume and Issue: 26(11), P. 6289 - 6317
Published: Jan. 1, 2024
Chemistry in water, leveraging its solvent properties, provides a safer and more sustainable alternative to traditional organic methods.
Language: Английский
Citations
23