Polyoxometalates,
Journal Year:
2024,
Volume and Issue:
3(3), P. 9140061 - 9140061
Published: Feb. 19, 2024
The
design
and
synthesis
of
a
bifunctional
catalyst
to
tackle
environmental
pollution
caused
by
2-chloroethyl
ethyl
sulfide
(CEES)
phenolic
compounds
is
meaningful.
In
this
study,
new
three-dimensional
(3D)
polyoxovanadate
(POV)-based
metal–organic
framework,
[Co(L)(V4O12)0.5(H2O)]·2H2O
(1;
L
=
N,N'-bis(3-methylpyridin-3-yl)-2,6-naphthalenediamide),
was
synthesized
under
hydrothermal
conditions.
1
characterized
using
single-crystal
X-ray
diffraction
analysis,
infrared
spectroscopy,
powder
diffraction.
Structural
analysis
shows
that
the
[V4O12]4–
clusters
pairs
Co2+
cations
are
alternately
connected
form
one-dimensional
inorganic
chain,
eventually
generating
3D
(4,4)-connected
framework
through
expansion
L,
which
exhibits
two
fold
interpenetration
array.
As
catalyst,
satisfactory
catalytic
properties
for
selective
oxidation
corresponding
sulfoxide,
with
an
effective
conversion
>
99%
selectivity
97%.
Furthermore,
excellent
photocatalytic
degradation
activity
toward
phenol,
2-chlorophenol,
m-cresol
visible
light.
efficiencies
were
above
92.6%
140
min.
reaction
kinetics,
mechanisms
photodegradation,
recycling
capability
phenol
also
investigated
in
detail.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(3), P. e25445 - e25445
Published: Feb. 1, 2024
Arabinoxylans
(AX)
have
become
a
focal
point
in
the
pharmaceutical
sector
owing
to
their
physicochemical,
biological,
and
functional
properties.
The
purpose
of
this
paper
was
present
summary
utilization
AX
as
drug
release
matrices
through
bibliometric
analysis
(BA)
literature
review
spotlight
characteristics
technological
applications
promote
line
research.
BA
carried
out
using
data
from
Web
Science
database
research,
specifically
emphasizing
authors'
keywords.
This
approach
chosen
due
its
significance
comprehensively
understanding
particular
research
field
relevance
for
in-depth
knowledge
field.
outcomes
revealed
limited
information
concerning
both
excipients
formulation
development
delivery
systems
(DDS),
so
there
is
need
additional
scientific
these
areas
address
existing
gaps.
However,
shows
that
native
modified
different
systems,
such
macrogels
(including
films,
tablets,
hard
gelatin
capsules)
multi-particulate
micro
nanogels),
an
excellent
potential
biomolecules
drugs,
doxorubicin,
diclofenac
sodium,
caffeine,
gentamicin,
tizanidine
hydrochloride,
insulin.
In
conclusion,
wide
application
industry,
work
expected
be
reference
future
by
scientists,
technologists,
entrepreneurs
who
cope
with
subject.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(10), P. 1269 - 1269
Published: Oct. 9, 2024
Poly(ADP-ribose)
polymerases
(PARPs)
are
crucial
nuclear
proteins
that
play
important
roles
in
various
cellular
processes,
including
DNA
repair,
gene
transcription,
and
cell
death.
Among
the
17
identified
PARP
family
members,
PARP1
is
most
abundant
enzyme,
with
approximately
1-2
million
molecules
per
cell,
acting
primarily
as
a
damage
sensor.
It
has
become
promising
biological
target
for
anticancer
drug
studies.
Enhanced
expression
present
several
types
of
tumors,
such
melanomas,
lung
cancers,
breast
correlating
low
survival
outcomes
resistance
to
treatment.
inhibitors,
especially
newly
developed
third-generation
inhibitors
currently
undergoing
Phase
II
clinical
trials,
have
shown
efficacy
agents
both
single
drugs
sensitizers
chemo-
radiotherapy.
This
review
explores
properties,
characteristics,
challenges
discussing
their
development
from
first-generation
compounds,
more
sustainable
synthesis
methods
discovery
new
anti-cancer
agents,
mechanisms
therapeutic
action,
potential
targeting
additional
targets
beyond
catalytic
active
site
proteins.
Perspectives
on
green
chemistry
also
discussed.
