Intelligent Biomaterialomics: Molecular Design, Manufacturing, and Biomedical Applications DOI Open Access
Yu Yi, Hong‐Wei An, Hao Wang

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(22)

Published: July 25, 2023

Abstract Materialomics integrates experiment, theory, and computation in a high‐throughput manner, has changed the paradigm for research development of new functional materials. Recently, with rapid characterization machine‐learning technologies, establishment biomaterialomics that tackles complex physiological behaviors become accessible. Breakthroughs clinical translation nanoparticle‐based therapeutics vaccines have been observed. Herein, recent advances biomaterials, including polymers, lipid‐like materials, peptides/proteins, discovered through screening or machine learning‐assisted methods, are summarized. The molecular design structure‐diversified libraries; characterization, screening, preparation; and, their applications drug delivery discussed detail. Furthermore, prospects main challenges future highlighted.

Language: Английский

Stimuli‐Responsive Peptide Self‐Assembly to Construct Hydrogels with Actuation and Shape Memory Behaviors DOI

Yanxin Xiang,

Can Liu,

Shinan Ma

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(34)

Published: May 5, 2023

Abstract Hydrogel actuators, capable of generating reversible deformation in response to external stimulus, are widely considered as new emerging intelligent materials for applications soft robots, smart sensors, artificial muscles, and so on. Peptide self‐assembly is applied the construction hydrogel due their excellent stimulus response. However, actuators based on peptide rarely reported explored. In this study, a pH‐responsive (MA‐FIID) designed introduced into poly( N ‐isopropyl acrylamide) backbone (PNIPAM) construct bilayer heterogeneous assembly disassembly molecules under different pH conditions. These peptide‐containing can perform controllable bending, bucking, complex stimulation. Meanwhile, Hofmeister effect PNIPAM hydrogels endows these with enhanced mechanical strength, ionic (CaCl 2 ), shape‐memory property. This work broadens application supramolecular hydrogels, also provides inspirations materials.

Language: Английский

Citations

58
3D Printing of Self‐Assembling Nanofibrous Multidomain Peptide Hydrogels DOI Creative Commons
Adam C. Farsheed, Adam J. Thomas, Brett H. Pogostin

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(11)

Published: Jan. 6, 2023

3D printing has become one of the primary fabrication strategies used in biomedical research. Recent efforts have focused on hydrogels to create structures that better replicate mechanical properties biological tissues. These pose a unique challenge, as soft materials are difficult pattern three dimensions with high fidelity. Currently, small number biologically derived polymers form frequently reused for applications. Thus, there exists need novel desirable can be printable inks. In this work, printability multidomain peptides (MDPs), class self-assembling nanofibrous hydrogel at low concentrations, is established. MDPs different charge functionalities optimized distinct inks and complex structures, including multi-MDP prints. Additionally, printed MDP constructs demonstrate charge-dependent differences cellular behavior vitro. This work presents first time been print layered overhangs internal porosity. Overall, promising new uniquely peptide-based rely solely supramolecular mechanisms assembly.

Language: Английский

Citations

45
Non-classical crystallization in soft and organic materials DOI
Jingshan S. Du, Yuna Bae, James J. De Yoreo

et al.

Nature Reviews Materials, Journal Year: 2024, Volume and Issue: 9(4), P. 229 - 248

Published: Feb. 6, 2024

Language: Английский

Citations

34
Preparation and Properties of Self-Assembling Polypeptide Hydrogels and Their Application in Biomedicine DOI
Pengbao Shi,

Xiangqiong He,

Hailin Cong

et al.

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(5), P. 1649 - 1677

Published: March 27, 2024

Hydrogels are widely used in the field of biomedicine due to their high water content and strong drug loading capacity. Different types quantities amino acids combined form a wide variety peptides. At same time, self-assembled peptide hydrogel is formed from into nanofibers, nanofibers further wound three-dimensional structure hydrogel. This special composition give characteristics properties. Polypeptide-based hydrogels have applications biomedical field. Therefore, it far-reaching significance deeply understand polypeptide-based explore applications. paper introduces structure, preparation, properties, biological self-assembling hydrogels. future development gels prospected.

Language: Английский

Citations

19
Self‐Assembled Nanocarrier Delivery Systems for Bioactive Compounds DOI
Yafei Zhang, Yuning Zhang, Rui Ding

et al.

Small, Journal Year: 2024, Volume and Issue: 20(26)

Published: Jan. 12, 2024

Abstract Although bioactive compounds (BCs) have many important functions, their applications are greatly limited due to own defects. The development of nanocarriers (NCs) technology has gradually overcome the defects BCs. NCs equally as BCs some extent. Self‐assembly (SA) methods build advantages than chemical methods, and SA significant impact on structure function NCs. However, relationship among mechanism, structure, not been given enough attention. Therefore, from perspective bottom‐up building concept SA‐structure‐function is emphasized promote SA‐based First, conditions forces for occurring introduced, then basis molecular mechanism protein, polysaccharide, lipid summarized. Then, varieties structures formed based introduced in detail. Finally, facing how be well solved by also elaborated. This review attempts describe great significance constructing artificial deliver aspects SA‐structure‐function, so wide application

Language: Английский

Citations

18
Peptide hydrogen-bonded organic frameworks DOI Creative Commons
Thangavel Vijayakanth,

Sneha Dasgupta,

Pragati Ganatra

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(8), P. 3640 - 3655

Published: Jan. 1, 2024

This tutorial review discusses the design principles, implications, and future challenges associated with peptide-based hydrogen-bonded porous frameworks (P-HPFs).

Language: Английский

Citations

17
Sulfatase-Induced In Situ Formulation of Antineoplastic Supra-PROTACs DOI

Ninglin Chen,

Zeyu Zhang, Xin Liu

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(15), P. 10753 - 10766

Published: April 5, 2024

Proteolysis targeting chimera (PROTAC) technology is an innovative strategy for cancer therapy, which, however, suffers from poor delivery and limited capability protein of interest (POI) degradation. Here, we report a the in situ formulation antineoplastic Supra-PROTACs via intracellular sulfatase-responsive assembly peptides. Coassembling sulfated peptide with two ligands binding to ubiquitin VHL Bcl-xL leads formation pro-Supra-PROTAC, which ratio rationally optimized based on their affinity. The resulting pro-Supra-PROTAC precisely undergoes enzyme-responsive into nanofibrous cells overexpressing sulfatase. Mechanistic studies reveal that pro-Supra-PROTACs selectively cause apparent cytotoxicity through degradation activation caspase-dependent apoptosis, during ligand improves bioactivity POI cell death. In vivo show enhanced tumor accumulation retention pro-Supra-PROTACs, as well inhibiting growth excellent biosafety when coadministrating chemodrugs. Our findings provide new approach enzyme-regulated peptides living development PROTACs high delivering efficiency.

Language: Английский

Citations

16
Self‐Assembling Peptide‐Based Functional Biomaterials DOI

Yehong Huo,

Jian Hu, Yuanyuan Yin

et al.

ChemBioChem, Journal Year: 2022, Volume and Issue: 24(2)

Published: Nov. 8, 2022

Peptides can self-assemble into various hierarchical nanostructures through noncovalent interactions and form functional materials exhibiting excellent chemical physical properties, which have broad applications in bio-/nanotechnology. The self-assembly mechanism, morphology of peptide supramolecular architecture their applications, been widely explored the merit biocompatibility, easy preparation, controllable functionality. Herein, we introduce latest research progress self-assembling peptide-based nanomaterials review biomedicine optoelectronics, including tissue engineering, anticancer therapy, biomimetic catalysis, energy harvesting. We believe that this will inspire rational design development novel bio-inspired future.

Language: Английский

Citations

65
Histidine as a key modulator of molecular self-assembly: Peptide-based supramolecular materials inspired by biological systems DOI Open Access
Yu Chen, Kai Tao, Wei Ji

et al.

Materials Today, Journal Year: 2022, Volume and Issue: 60, P. 106 - 127

Published: Aug. 28, 2022

Language: Английский

Citations

62
In Situ Self-Sorting Peptide Assemblies in Living Cells for Simultaneous Organelle Targeting DOI
Xin Liu, Mingming Li,

Juanzu Liu

et al.

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(21), P. 9312 - 9323

Published: May 19, 2022

Self-sorting is a common phenomenon in eukaryotic cells and represents one of the versatile strategies for formation advanced functional materials; however, developing artificial self-sorting assemblies within living remains challenging. Here, we report on GSH-responsive situ peptide cancer simultaneous organelle targeting to promote combinatorial dysfunction thereby cell death. The system was created via design two peptides E3C16E6 EVMSeO derived from lipid-inspired interdigitating amphiphiles bola-amphiphiles, respectively. distinct organization patterns facilitate their GSH-induced into isolated nanofibrils as result cleavage disulfide-connected hydrophilic domains or reduction selenoxide groups. HeLa directly characterized by super-resolution structured illumination microscopy. Incorporation thiol ER-targeting groups self-sorted endows endoplasmic reticulum Golgi apparatus, thus leading Our results demonstrate establishment cells, providing unique platform drug delivery an alternative strategy modulating biological processes future.

Language: Английский

Citations

58