Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(22)
Published: July 25, 2023
Abstract
Materialomics
integrates
experiment,
theory,
and
computation
in
a
high‐throughput
manner,
has
changed
the
paradigm
for
research
development
of
new
functional
materials.
Recently,
with
rapid
characterization
machine‐learning
technologies,
establishment
biomaterialomics
that
tackles
complex
physiological
behaviors
become
accessible.
Breakthroughs
clinical
translation
nanoparticle‐based
therapeutics
vaccines
have
been
observed.
Herein,
recent
advances
biomaterials,
including
polymers,
lipid‐like
materials,
peptides/proteins,
discovered
through
screening
or
machine
learning‐assisted
methods,
are
summarized.
The
molecular
design
structure‐diversified
libraries;
characterization,
screening,
preparation;
and,
their
applications
drug
delivery
discussed
detail.
Furthermore,
prospects
main
challenges
future
highlighted.
Journal of the American Chemical Society,
Journal Year:
2022,
Volume and Issue:
144(15), P. 6907 - 6917
Published: April 7, 2022
Enzyme-regulated
in
situ
self-assembly
of
peptides
represents
one
versatile
strategy
the
creation
theranostic
agents,
which,
however,
is
limited
by
strong
dependence
on
enzyme
overexpression.
Herein,
we
reported
self-amplifying
assembly
precisely
macrophages
associated
with
expression
for
improving
anti-inflammatory
efficacy
conventional
drugs.
The
assembling
system
was
created
via
coassembling
an
enzyme-responsive
peptide
its
derivative
functionalized
a
protein
ligand.
Reduction
NAD(P)H
quinone
dehydrogenase
1
(NQO1)
led
to
formation
nanofibers
high
affinity
protein,
thereby
facilitating
NQO1
expression.
improved
level
conversely
promoted
into
nanofibers,
thus
establishing
amplifying
relationship
between
and
macrophages.
Utilization
as
vehicles
drug
dexamethasone
allowed
passive
targeting
delivery
acute
injured
lungs.
Both
vitro
vivo
studies
confirmed
capability
enhance
simultaneous
alleviation
reactive
oxygen
species
side
effect
downregulation
proinflammatory
cytokines.
Our
findings
demonstrate
manipulation
living
cells
regular
self-amplification
process,
providing
unique
supramolecular
agents
cells.
Journal of the American Chemical Society,
Journal Year:
2022,
Volume and Issue:
144(36), P. 16232 - 16251
Published: Aug. 31, 2022
The
complexity
and
diversity
of
biomacromolecules
make
them
a
unique
class
building
blocks
for
generating
precise
assemblies.
They
are
particularly
available
to
new
generation
biomaterials
integrated
with
living
systems
due
their
intrinsic
properties
such
as
accurate
recognition,
self-organization,
adaptability.
Therefore,
many
excellent
approaches
have
been
developed,
leading
variety
quite
practical
outcomes.
Here,
we
review
recent
advances
in
the
fabrication
application
artificially
assemblies
by
employing
proteins
carbohydrates
blocks,
followed
our
perspectives
on
some
challenges,
goals,
opportunities
future
research
directions
this
field.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(15), P. 4843 - 4877
Published: Jan. 1, 2023
Unnatural
helical
peptidic
foldamers
have
attracted
considerable
attention
owing
to
their
unique
folding
behaviours,
diverse
artificial
protein
binding
mechanisms,
and
promising
applications
in
chemical,
biological,
medical,
material
fields.
Unlike
the
conventional
α-helix
consisting
of
molecular
entities
native
α-amino
acids,
unnatural
are
generally
comprised
well-defined
backbone
conformers
with
structural
parameters.
Their
folded
structures
usually
arise
from
amino
acids
such
as
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(29)
Published: March 18, 2024
Abstract
Biologically
inspired
peptide‐based
materials,
as
novel
charge
transport
have
gained
increasing
interest
in
bioelectronics
due
to
their
remarkable
electrical
properties
and
inherent
biocompatibility.
Extensive
studies
shown
that
peptides
can
self‐assemble
into
a
variety
of
hierarchical
nanostructures
with
unique
physical
through
supramolecular
interactions.
Therefore,
materials
hold
great
promise
for
applications
emerging
electronic
fields
such
sensing,
energy
harvesting,
storage,
transmission.
Herein,
this
work
proposes
review
article
summarize
the
rational
design
research
progress
devices
bioelectronics.
This
first
introduces
strategies
assembly
mechanism
constructing
high‐performance
devices.
In
following
part,
are
systematically
classified
discussed,
including
sensors,
piezoelectric
nanogenerators,
electrodes,
semiconductors.
Finally,
remaining
challenges
future
perspectives
bioelectronic
presented.
believes
will
provide
inspiration
guidance
development
innovative
smart
field
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(23)
Published: March 6, 2024
The
presence
of
bacteria
in
tumor
results
chemotherapeutic
drug
resistance
and
weakens
the
immune
response
colorectal
cancer.
To
overcome
bacterium-induced
potentiate
antitumor
immunity,
herein
a
novel
molecule
Biotin-Lys(SA-Cip-OH)-Lys(SA-CPT)-Phe-Phe-Nap
(Biotin-Cip-CPT-Nap)
is
rationally
designed
containing
four
functional
motifs
(i.e.,
biotin
motif
for
targeting,
Phe-Phe(-Nap)
self-assembly,
ciprofloxacin
derivative
(Cip-OH)
antibacterial
effect,
camptothecin
(CPT)
chemotherapy).
Using
molecule,
strategy
intracellular
enzymatic
nanofiber
formation
synergistic
antibacterium-enhanced
chemotherapy
immunotherapy
achieved.
Under
endocytosis
mediated
by
highly
expressed
receptor
cancer
cell
membrane
catalysis
carboxylesterase
cytoplasm,
this
can
be
transformed
into
Biotin-Nap,
which
self-assembled
nanofibers.
Meanwhile,
antibiotic
Cip-OH
CPT
are
released,
overcoming
enhancing
therapeutic
efficacy
towards
This
work
offers
feasible
design
multifunctional
prodrugs
to
improve
efficiency
treatment.
