Nanoscale,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 16, 2024
In
this
study,
we
demonstrate
a
unique
and
promising
approach
to
access
peptide-based
diverse
nanostructures
in
single
gelator
regime
that
is
capable
of
exhibiting
different
surface
topographies
variable
physical
properties,
which,
turn,
can
effectively
mimic
the
extracellular
matrix
(ECM)
regulate
cellular
responses.
These
represent
energy
states
free
landscape,
which
have
been
created
through
self-assembling
pathways
by
providing
inputs
simply
altering
gelation
induction
temperature
from
40
°C
90
°C.
The
highly
entangled
network
structure
with
long
fibers
was
higher
inputs,
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(29)
Published: April 28, 2024
Abstract
Tactile
sensing
requires
integrated
detection
platforms
with
distributed
and
highly
sensitive
haptic
capabilities
along
biocompatibility,
aiming
to
replicate
the
physiological
functions
of
human
skin
empower
industrial
robotic
prosthetic
wearers
detect
tactile
information.
In
this
regard,
short
peptide‐based
self‐assembled
hydrogels
show
promising
potential
act
as
bioinspired
supramolecular
substrates
for
developing
sensors
showing
biocompatibility
biodegradability.
However,
intrinsic
difficulty
modulate
mechanical
properties
severely
restricts
their
extensive
employment.
Herein,
by
controlling
self‐assembly
9‐fluorenylmethoxycarbonyl‐modifid
diphenylalanine
(Fmoc‐FF)
through
introduction
polyethylene
glycol
diacrylate
(PEGDA),
wider
nanoribbons
are
achieved
untwisting
from
well‐established
thinner
nanofibers,
can
be
enhanced
10‐fold,
supplying
encapsulating
substrate
sensing.
Furthermore,
doping
poly(3,4‐ethylenedioxythiophene):poly(styrene
sulfonate)
(PEDOT:PSS)
3,4‐dihydroxy‐
l
‐phenylalanine
(Fmoc‐DOPA),
Fmoc‐FF
engineered
conductive
adhesive,
providing
units
adhesive
layer
applications.
Therefore,
integration
these
modules
results
in
peptide
hydrogelation‐based
sensors,
high
sensitivity
sustainable
responses
The
findings
establish
feasibility
programmable
adjustable
features
Materials,
Journal Year:
2025,
Volume and Issue:
18(3), P. 654 - 654
Published: Feb. 1, 2025
The
development
of
functional
materials
and
the
use
nanotechnology
are
ongoing
projects.
These
fields
closely
linked,
but
there
is
a
need
to
combine
them
more
actively.
Nanoarchitectonics,
concept
that
comes
after
nanotechnology,
ready
do
this.
Among
related
research
efforts,
into
creating
through
formation
thin
layers
on
surfaces,
molecular
membranes,
multilayer
structures
these
have
lot
implications.
Layered
especially
important
as
key
part
nanoarchitectonics.
diversity
components
used
in
layer-by-layer
(LbL)
assemblies
notable
feature.
Examples
LbL
introduced
this
review
article
include
quantum
dots,
nanoparticles,
nanocrystals,
nanowires,
nanotubes,
g-C3N4,
graphene
oxide,
MXene,
nanosheets,
zeolites,
nanoporous
materials,
sol–gel
layered
double
hydroxides,
metal–organic
frameworks,
covalent
organic
conducting
polymers,
dyes,
DNAs,
polysaccharides,
nanocelluloses,
peptides,
proteins,
lipid
bilayers,
photosystems,
viruses,
living
cells,
tissues.
examples
assembly
show
how
useful
versatile
it
is.
Finally,
will
consider
future
challenges
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(25)
Published: Feb. 21, 2024
Abstract
Peptide‐based
supramolecular
therapeutics
(PST)
refer
to
those
theranostic
nanomedicines
based
on
peptide
or
derivatives
self‐assembly
that
are
constructed
in
vitro
vivo.
Benefiting
from
the
inherent
advantages
of
peptides,
such
as
good
biocompatibility,
high
bioactivity,
and
flexible
tunability,
reported
PST
have
shown
excellent
application
prospects
combating
many
major
diseases
including
cancer,
cardiovascular
disease,
infectious
autoimmune
metabolic
so
on.
Through
thoughtful
design,
can
be
fabricated
various
forms,
self‐assembled
precursor
molecules,
functional
nano‐assemblies,
macroscopic
large‐scale
hydrogels.
The
involved
peptides
play
different
roles,
serving
drug
carriers
for
effective
delivery,
acting
scaffold
materials
cell
culture,
functioning
bioactive
sequences
treating
diseases.
In
this
review,
a
comprehensive
overview
traditional
strategies
is
provided
build
emphasize
their
therapeutic
applications
fighting
pose
threat
human
life
health.
Moreover,
main
challenges
systems
application,
clinical
translation
also
briefly
discussed.
It
hoped
review
arouse
much
more
attention
paid
promote
its
practical
biomedical
field.
Exploration,
Journal Year:
2024,
Volume and Issue:
4(4)
Published: Jan. 23, 2024
Self-assembled
peptides
have
been
among
the
important
biomaterials
due
to
its
excellent
biocompatibility
and
diverse
functions.
Over
past
decades,
substantial
progress
breakthroughs
made
in
designing
self-assembled
with
multifaceted
biomedical
applications.
The
techniques
for
quantitative
analysis,
including
imaging-based
techniques,
chromatographic
technique
computational
approach
(molecular
dynamics
simulation),
are
becoming
powerful
tools
exploring
structure,
properties,
applications,
even
supramolecular
assembly
processes
of
peptides.
However,
a
comprehensive
review
concerning
these
remains
scarce.
In
this
review,
recent
investigation
biostability,
cellular
uptake,
biodistribution,
self-assembly
behaviors
peptide
etc.,
summarized.
Specific
applications
roles
highlighted
detail.
Finally,
challenges
outlook
field
concluded.
It
is
believed
that
will
provide
technical
guidance
researchers
peptide-based
materials
pharmaceuticals,
facilitate
related
research
newcomers
field.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(32)
Published: May 17, 2024
Abstract
Dynamic
chemistry
utilizing
both
covalent
and
noncovalent
bonds
provides
valid
protocols
in
manipulating
properties
of
self‐assemblies
functions.
Here
we
employ
dynamic
to
realize
multiple‐route
control
over
supramolecular
chirality
up
five
states.
N‐protected
fluorinated
phenylalanine
the
carboxylate
state
self‐assembled
into
achiral
nanoparticles
ascribed
amphiphilicity.
Protonation
promoted
one‐dimensional
growth
helices
with
shrunk
hydrophilicity,
which
presence
disulfide
pyridine
undergo
inversion
by
hydrogen
bonding‐directed
coassembly.
Further
interacting
water‐soluble
reductant
cleavages
bond
initiate
rearrangement
coassemblies
a
as
well.
Finally,
tuning
pH
environments,
aromatic
nucleophilic
substitution
reaction
between
reduced
products
perfluorinated
occurs,
giving
distinct
chiral
nanoarchitectures
emerged
luminescence
circularly
polarized
luminescence.
We
thus
realized
particular
five‐state
combining
at
one
compound,
greatly
enriches
toolbox
fabricating
responsive
chiroptical
materials.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 22, 2025
Abstract
Bioinspired
supramolecular
architectonics
is
attracting
increasing
interest
due
to
their
flexible
organization
and
multifunctionality.
However,
state‐of‐the‐art
bioinspired
generally
take
place
in
solvent‐based
circumstance,
thus
leading
achieving
precise
control
over
the
self‐assembly
remains
challenging.
Moreover,
intrinsic
difficulty
of
ordering
bio‐organic
self‐assemblies
into
stable
large‐scale
arrays
liquid
environment
for
engineering
devices
severely
restricts
extensive
applications.
Herein,
a
gaseous
strategy
proposed
with
physical
vapor
deposition
(PVD)
technology,
allowing
monomers
not
only
self‐assemble
architectures
well‐established
from
approaches
but
morphologies
distinct
those
delivered
cases.
Specifically,
9‐fluorenylmethyloxycarbonyl‐phenylalanine‐phenylalanine
(Fmoc‐FF)
self‐assembles
spheres
tailored
dimensions
rather
than
conventional
nanofibers,
mechanisms.
Arraying
spherical
can
integrate
behaviors,
endorsing
film
ability
programmable
optoelectronic
properties,
which
be
employed
design
P‐N
heterojunction‐based
bio‐photocapacitors
non‐invasive
nongenetic
neurostimulations.
The
findings
demonstrate
that
may
offer
an
alternative
approach
achieve
unprecedented
superstructures,
allow
behavior
integration,
potentially
paving
avenue
developing
promoting
practical
applications
architectonics.
