Multifunctional mesoporous silica nanoparticles for biomedical applications

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Nov. 24, 2023

Abstract Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of nanotechnology applied in the biomedical field, due to their easily tunable structure and composition, diverse surface functionalization properties, excellent biocompatibility. Over past two decades, researchers have developed wide variety MSNs-based nanoplatforms through careful design controlled preparation techniques, demonstrating adaptability various application scenarios. With continuous breakthroughs MSNs fields biosensing, disease diagnosis treatment, tissue engineering, etc., gradually moving from basic research clinical trials. In this review, we provide detailed summary beginning with comprehensive overview development history. We then discuss types nanostructured architectures, well classification nanocomposites according elements existed inorganic functional components. Subsequently, summarize primary purposes surface-functionalized modifications MSNs. following, applications MSNs, highlight targeted therapeutic modalities currently developed. Given importance translation, also progress Finally, take perspective on future direction remaining challenges field.

Language: Английский

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High-brightness transition metal-sensitized lanthanide near-infrared luminescent nanoparticles

Nature Photonics, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

Language: Английский

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Rare‐Earth‐Based Lead‐Free Halide Double Perovskites for Light Emission: Recent Advances and Applications

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)

Published: May 22, 2024

Abstract The double perovskite material of Cs 2 NaRECl 6 ‐type, utilizing rare‐earth (RE) ions as trivalent element, has attracted widespread interest due to its unique optoelectronic properties and wide range applications. It displays rich optical properties, including visible infrared light emission through down‐shifting, well up‐conversion radiation‐induced emission. These exceptional make it a promising for devices such detectors, light‐emitting diodes, lasers energy storage batteries but also show advantages in anti‐counterfeiting technology imaging. In this article, the latest progress is reported challenges crystal structure, preparation, performance, various applications lead‐free halide (HLDPs) compounds. This outline prospective research directions existing materials, with aim facilitating discovery new HLDPs materials.

Language: Английский

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Tunable Anti‐Thermal Quenching Luminescence of Eu³⁺‐Doped Metal‐Organic Framework and Temperature‐Dependent Photonic Coding

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(33)

Published: March 22, 2024

Abstract Applications of luminescence at high temperature such as high‐power lighting, lasing, thermophotovoltaics, and photonic coding, are severely prevented due to the notorious thermal quenching (TQ). Although anti‐TQ (anti‐TQL) is reported using highly oxygen‐coordinated solid‐state oxide host in virtue rigid skeleton that resists lattice vibration elevated temperatures, it meaningful extend anti‐TQL other hosts. Herein, taking advantage ligand‐metal antenna effect negative expansion feature Eu 3+ doped MIL‐68‐In (MIL‐68‐In/xEu), adjustable realized for first time, is, anti‐TQ, zero‐TQ, TQ x = 5%, 10%, 50%, respectively. Therefore, except added novel mechanisms, this work has also expanded hosts available high‐temperature enabled advanced coding terms facial synthesis, rich information, visual changes emission intensity instead device‐dependent analogous.

Language: Английский

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An Emerging Toolkit of Ho³⁺ Sensitized Lanthanide Nanocrystals with NIR-II Excitation and Emission for in Vivo Bioimaging

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Optical imaging in the second near-infrared window (NIR-II, 1000-1700 nm) holds great promise for biomedical detection due to reduced tissue scattering and autofluorescence. However, rational design of NIR-II probes with superior excitation wavelengths balance effects water absorption remains a challenge. To address this issue, here we developed series Ho

Language: Английский

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Luminescent Lanthanide Infinite Coordination Polymers for Ratiometric Sensing Applications

Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 396 - 396

Published: Jan. 18, 2025

Ratiometric lanthanide coordination polymers (Ln-CPs) are advanced materials that combine the unique optical properties of ions (e.g., Eu3+, Tb3+, Ce3+) with structural flexibility and tunability polymers. These widely used in biological chemical sensing, environmental monitoring, medical diagnostics due to their narrow-band emission, long fluorescence lifetimes, excellent resistance photobleaching. This review focuses on composition, sensing mechanisms, applications ratiometric Ln-CPs. The mechanism relies two distinct emission bands, which provides a self-calibrating, reliable, precise method for detection. relative intensity ratio between these bands varies concentration target analyte, enabling real-time monitoring minimizing interference. approach is particularly suitable detecting trace analytes use complex environments where factors like background noise, temperature fluctuations, light variations may affect results. Finally, we outline future research directions improving design synthesis Ln-CPs, such as incorporating long-lifetime reference luminescent molecules, exploring near-infrared systems, developing up-conversion or two-photon materials. Progress areas could significantly broaden scope Ln-CP applications, especially biosensing, other fields.

Language: Английский

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Spatially Selective MicroRNA Imaging in Human Colorectal Cancer Tissues Using a Multivariate-Gated Signal Amplification Nanosensor

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

MicroRNA (miRNA) is involved in the genesis viand development of colorectal cancer. The vivo imaging miRNA at tumor sites essential for understanding its role cancer pathology and therapeutic target identification. However, achieving accurate hindered by low abundance miRNAs cells nonspecific signal leakage normal tissues. Here, we report a multivariate-gated catalytic hairpin assembly (CHA) nanosensor specific amplified microRNA-21 (miR-21) human tissues to reveal underlying miR-21-associated molecular mechanism. endogenous glutathione exogenous near-infrared design combination with CHA probes improves strength miR-21 reduces background interference. enables vivo, signal-to-background ratios are 1.6-fold compared traditional methods. With assistance designed nanosensor, achieve preliminary identification from clinical surgical resection samples. overexpressed found suppress core mismatch repair recognition protein mutS homologue 2 DNA damage inhibit efficacy strategy probe design, which combines activation methods amplification system, applicable disease-relevant mechanism research.

Language: Английский

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Heterostructured Lanthanide Perovskite Nanoparticles with High Quantum Yield and Water Stability for Optical Information Storage

Advanced Optical Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Abstract In this study, heterostructured nanoparticles based on lanthanide double perovskite halide are innovatively proposed, which dramatically improved quantum yield and color purity, but the problem of water stability materials has also been solved. The without surface ligands have excellent optical properties when dispersed in water, higher purity than those organic solvents. Besides, application potential is demonstrated practical performance verified by preparing luminescent ink. This study provides a new strategy for enhancement prospect perovskite.

Language: Английский

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Stimuli‐responsive active materials for dynamic control of light field

Deleted Journal, Journal Year: 2023, Volume and Issue: 1(2)

Published: Oct. 19, 2023

Abstract The increasing demand for the multidimensional and dynamic control of light has spurred development stimuli‐responsive, reconfigurable, programmable optical systems. Liquid crystals (LCs), which combine liquid‐like stimuli‐responsiveness crystal‐like orientational ordering, have emerged as highly appealing soft materials. Owing to their exceptional performance functionalities, they are becoming incredibly important materials in active planar optics photonics. Additionally, silk proteins, luminescent materials, metasurfaces exhibit properties, enabling remarkable multifunctional applications. This review focuses on advancements stimuli‐responsive including LCs, well some these paired with LCs. Their attractive tunable applications photonics, along great potential future systems, also emphasized.

Language: Английский

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Cooperative Sensitization Upconversion in Solution Dispersions of Co‐Crystal Assemblies of Mononuclear Yb³⁺ and Eu³⁺ Complexes

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(24)

Published: April 11, 2023

Lanthanide upconversion luminescence in nanoparticles has prompted continuous breakthroughs information storage, temperature sensing, and biomedical applications, among others. Achieving at the molecular scale is still a critical challenge modern chemistry. In this work, we explored of solution dispersions co-crystals composed discrete mononuclear Yb(DBM)3 Bpy Eu(DBM)3 complexes (DBM: dibenzoylmethane, Bpy: 2,2'-bipyridine). The 613 nm emission Eu3+ was observed under excitation Yb3+ 980 nm. From series assemblies studied, most intense obtained for 1 : molar ratio , resulting high quantum yield 0.67 % 2.1 W cm-2 . structure energy transfer mechanism were fully characterized. This first example an -based upconverting system two lanthanide present as non-deuterated solution.

Language: Английский

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