Core–Shell Microgels at Air/Water Interfaces: Role of Interfacial Tension in Monolayer Evolution DOI Creative Commons
Yichu Zhou, Jérôme J. Crassous, Matthias Karg

et al.

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Core–shell microgels with rigid cores and soft, deformable hydrogel shells can assemble at air–water interfaces, forming freely floating monolayers. The strong adsorption such interfaces is related to the reduction in interfacial tension, which also causes deform laterally. degree of this deformation typically controlled through applied surface pressure. Until now, surprisingly little has been known about impact tension imbalances between areas covered a microgel monolayer microgel-free surroundings. In work, we systematically study evolution air/water dependence by addition sodium dodecyl sulfate or linear poly-N-isopropylacrylamide homopolymer free area. We do globally monitoring area Macroscopic changes are local microstructure studied atomic force microscopy (AFM). Depending on imbalance, either expands, shrinks, maintains its conformation. kinetics expansion compared for core–shell same silica core varying cross-linker densities. Our reveals behavior monolayers liquid provides useful insights into controlling two-dimensional (2D) without need Langmuir trough.

Language: Английский

Recent advances in biomimetic nanodelivery systems: New brain-targeting strategies DOI
Jun Liao,

Li Fan,

Yi Li

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 358, P. 439 - 464

Published: May 13, 2023

Language: Английский

Citations

59
Advances and future perspectives of intranasal drug delivery: A scientometric review DOI
Dong Xu, Xujiao Song,

Xue Chen

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 367, P. 366 - 384

Published: Feb. 1, 2024

Language: Английский

Citations

19
Concepts and Approaches to Reduce or Avoid Protein Corona Formation on Nanoparticles: Challenges and Opportunities DOI Creative Commons
Matthias Barz, Wolfgang J. Parak, Rudolf Zentel

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 8, 2024

This review describes the formation of a protein corona (or its absence) on different classes nanoparticles, basic principles, and consequences for nanomedicine. For this purpose, it general concepts to control (guide/minimize) interaction between artificial nanoparticles plasma proteins reduce formation. Thereafter, methods qualitative or quantitative determination are presented, as well properties nanoparticle surfaces, which relevant prevention formation). Thereby especially role grafting density hydrophilic polymers surface is discussed prevent corona. In context also potential detergents (surfactants) temporary modification grafting-to grafting-from approaches permanent discussed. The concludes by highlighting several promising avenues. includes (i) use without active targeting, (ii) synthetic address immune system, (iii) recollection with defined after in vivo application sample blood proteome (iv) further

Language: Английский

Citations

19
Self‐Assembled Nanocarrier Delivery Systems for Bioactive Compounds DOI
Yafei Zhang, Yuning Zhang, Rui Ding

et al.

Small, Journal Year: 2024, Volume and Issue: 20(26)

Published: Jan. 12, 2024

Abstract Although bioactive compounds (BCs) have many important functions, their applications are greatly limited due to own defects. The development of nanocarriers (NCs) technology has gradually overcome the defects BCs. NCs equally as BCs some extent. Self‐assembly (SA) methods build advantages than chemical methods, and SA significant impact on structure function NCs. However, relationship among mechanism, structure, not been given enough attention. Therefore, from perspective bottom‐up building concept SA‐structure‐function is emphasized promote SA‐based First, conditions forces for occurring introduced, then basis molecular mechanism protein, polysaccharide, lipid summarized. Then, varieties structures formed based introduced in detail. Finally, facing how be well solved by also elaborated. This review attempts describe great significance constructing artificial deliver aspects SA‐structure‐function, so wide application

Language: Английский

Citations

18
Interactions between interfaces dictate stimuli-responsive emulsion behaviour DOI Creative Commons
Marcel Rey, Jannis Kolker, James A. Richards

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Oct. 23, 2023

Stimuli-responsive emulsions offer a dual advantage, combining long-term storage with controlled release triggered by external cues such as pH or temperature changes. This study establishes that thermo-responsive emulsion behaviour is primarily determined interactions between, rather than within, interfaces. Consequently, the stability of these intricately tied to nature stabilizing microgel particles - whether they are more polymeric colloidal, and morphology assume at liquid interface. The colloidal properties microgels provide foundation for Pickering emulsions. However, limited deformability can lead non-responsive Conversely, enable them spread flatten interface, enabling stimuli-responsive behaviour. Furthermore, shared between two droplets in flocculated facilitate stimuli-responsiveness, regardless their internal architecture. underscores pivotal role forces exert on interfaces control design

Language: Английский

Citations

28
Nanotechnology in inflammation: cutting-edge advances in diagnostics, therapeutics and theranostics DOI Creative Commons
Yuting Liu, Ziqi Lin, Yuting Wang

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 14(6), P. 2490 - 2525

Published: Jan. 1, 2024

Inflammatory dysregulation is intimately associated with the occurrence and progression of many life-threatening diseases.Accurate detection timely therapeutic intervention on inflammatory are crucial for effective therapy inflammation-associated diseases.However, clinical outcomes inflammation-involved disorders still unsatisfactory.Therefore, there an urgent need to develop innovative anti-inflammatory strategies by integrating emerging technological innovations traditional therapeutics.Biomedical nanotechnology one promising fields that can potentially transform diagnosis treatment inflammation.In this review, we outline recent advances in biomedical inflammation, special attention paid nanosensors nanoprobes precise inflammation-related diseases, nanotherapeutics, as well nanotheranostics combined applications.Moreover, prospects challenges translation nanomedicines highlighted.

Language: Английский

Citations

14
Softness‐Aided Mild Hyperthermia Boosts Stiff Nanomedicine by Regulating Tumor Mechanics DOI Creative Commons
Zheng Li,

Yabo Zhu,

Zhijie Zhang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(26)

Published: May 5, 2024

Abstract Aberrant tumor mechanical microenvironment (TMME), featured with overactivated cancer‐associated fibroblasts (CAFs) and excessive extracellular matrix (ECM), severely restricts penetration accumulation of cancer nanomedicines, while mild‐hyperthermia photothermal therapy (mild‐PTT) has been developed to modulate TMME. However, agents also encounter the barriers established by TMME, manifesting in limited heterogeneous distribution across tissues ending attenuated efficiency TMME regulation. Herein, it is leveraged indocyanine green (ICG)‐loaded soft nanogels outstanding deformability, for efficient uniform distribution, combination mild‐PTT achieve potent regulation inhibiting CAFs degrading ECM. As a result, doxorubicin (DOX)‐loaded stiff gain greater benefits antitumor efficacy than counterparts from softness‐mediated mild‐PTT. This study reveals crucial role nanomedicine properties provides novel strategy overcoming solid tumors deformable nanogels.

Language: Английский

Citations

9
Nanogel/Microgel Science and Beyond DOI
Daisuke Suzuki

Langmuir, Journal Year: 2023, Volume and Issue: 39(22), P. 7525 - 7529

Published: May 23, 2023

Since the first report in 1986, tremendous effort has been devoted to developing a deeper understanding of hydrogel colloidal particles (i.e., nanogels/microgels), including their synthesis, characterization, assembly, computer simulation, and various applications. At present, many researchers from diverse scientific backgrounds are using nanogels/microgels for own research purposes, thus, there seem be several miscommunications. Here, order further accelerate development nanogel/microgel field, personal viewpoint on this topic is presented.

Language: Английский

Citations

22
Membrane-Mediated Interactions Between Nonspherical Elastic Particles DOI Creative Commons
Jiarul Midya, Thorsten Auth, Gerhard Gompper

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(3), P. 1935 - 1945

Published: Jan. 20, 2023

The transport of particles across lipid-bilayer membranes is important for biological cells to exchange information and material with their environment. Large often get wrapped by membranes, a process which has been intensively investigated in the case hard particles. However, many vivo vitro are deformable, e.g., vesicles, filamentous viruses, macromolecular condensates, polymer-grafted nanoparticles, microgels. Vesicles may serve as generic model system deformable Here, we study nonspherical vesicles various sizes, shapes, elastic properties at initially planar membranes. Using Helfrich Hamiltonian, triangulated energy minimization, predict interplay vesicle shapes wrapping states. Increasing particle softness enhances stability shallow-wrapped deep-wrapped states over nonwrapped complete-wrapped free membrane mediates an interaction between partial-wrapped vesicles. For pair repulsion. attraction tip-to-tip orientation repulsion side-by-side orientation. Our predictions guide design fabrication efficient use medical applications, such targeted drug delivery.

Language: Английский

Citations

19
Synthetic and biopolymeric microgels: Review of similarities and difference in behaviour in bulk phases and at interfaces DOI Creative Commons

Daisy Z. Akgonullu,

Brent S. Murray, Simon D. Connell

et al.

Advances in Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 320, P. 102983 - 102983

Published: Aug. 15, 2023

This review discusses the current knowledge of interfacial and bulk interactions biopolymeric microgels in relation to well-established properties synthetic for applications as viscosity modifiers Pickering stabilisers. We present a timeline showing key milestones designing their bulk/ performance. Poly(N-isopropylacrylamide) (pNIPAM) have remained protagonist microgel domain whilst proteins or polysaccharides been primarily used fabricate microgels. Bulk dispersions are dominated by volume fraction (ϕ) particles, but ϕ is difficult pinpoint, addressed many theoretical models. By evaluating recent experimental studies over last five years, we find an increasing focus on analysis elasticity parameter modulating packing at interfaces, within provinces both systems. Production methods physiochemical factors shown influence swelling aqueous phase can significant impact well Compared microgels, biopolymer show greater tendency polydispersity aggregation do not appear core-corona structure. Comprehensive still lacking, example, accurately determine inter- intra- particle interactions, wider variety techniques need be applied order allow comparisons real systems practical usage.

Language: Английский

Citations

18