Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(32), P. 7692 - 7759
Published: Jan. 1, 2024
Tissue engineering has emerged as a remarkable field aiming to repair or replace damaged tissues through the use of biomimetic constructs.
Language: Английский
Materials Today Bio, Journal Year: 2022, Volume and Issue: 18, P. 100522 - 100522
Published: Dec. 21, 2022
Extracellular vesicles (EVs) are a collective term for nanoscale or microscale secreted by cells that play important biological roles. Mesenchymal stem class of with the potential self-healing and multidirectional differentiation. In recent years, numerous studies have shown EVs, especially those mesenchymal cells, can promote repair regeneration various tissues and, thus, significant in regenerative medicine. However, due to rapid clearance capacity circulatory system, EVs barely able act persistently at specific sites target tissues. Hydrogels good biocompatibility loose porous structural properties allow them serve as EV carriers, thereby prolonging retention certain areas slowing release EVs. When needed function sites, EV-loaded hydrogels stand an excellent approach. this review, we first introduce sources, roles, extraction characterization methods describe their current application status. We then review different types discuss factors influencing abilities carry summarize several strategies loading into characterizing hydrogels. Furthermore, applications tissue repair. This article concludes summary state research on outlook future directions, which hope will provide promising ideas researchers.
Language: Английский
Citations
259
Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100582 - 100582
Published: Feb. 16, 2023
Hydrogels are essential biomaterials due to their favorable biocompatibility, mechanical properties similar human soft tissue extracellular matrix, and repair properties. In skin wound repair, hydrogels with antibacterial functions especially suitable for dressing applications, so novel hydrogel dressings have attracted widespread attention, including the design of components, optimization preparation methods, strategies reduce bacterial resistance, etc. this review, we discuss fabrication challenges associated crosslinking methods chemistry materials. We investigated advantages limitations (antibacterial effects mechanisms) different components in achieve good properties, response stimuli such as light, sound, electricity resistance. Conclusively, provide a systematic summary findings (crosslinking methods) an outlook on long-lasting effects, broader spectrum, diversified forms, future development prospects field.
Language: Английский
Citations
192
Advanced Science, Journal Year: 2023, Volume and Issue: 10(28)
Published: Aug. 6, 2023
Hydrogels with tailor-made swelling-shrinkable properties have aroused considerable interest in numerous biomedical domains. For example, as swelling is a key issue for blood and wound extrudates absorption, the transference of nutrients metabolites, well drug diffusion release, hydrogels high capacity been widely applicated full-thickness skin healing tissue regeneration, delivery. Nevertheless, fields adhesives internal soft-tissue healing, bioelectronics, non-swelling play very important functions owing to their stable macroscopic dimension physical performance physiological environment. Moreover, negative behavior (i.e., shrinkage) can be exploited drive noninvasive closure, achieve resolution enhancement hydrogel scaffolds. In addition, it help push out entrapped drugs, thus promote release. However, there still has not general review constructions applications from viewpoint properties. Therefore, this summarizes tactics employed so far tailoring applications. And relatively comprehensive understanding current progress future challenge different features provided potential clinical translations.
Language: Английский
Citations
171
Nature Reviews Materials, Journal Year: 2023, Volume and Issue: 8(9), P. 604 - 622
Published: Aug. 24, 2023
Language: Английский
Citations
133
Advanced Materials, Journal Year: 2023, Volume and Issue: 36(21)
Published: Nov. 22, 2023
Abstract Hydrogels have emerged as powerful building blocks to develop various soft bioelectronics because of their tissue‐like mechanical properties, superior bio‐compatibility, the ability conduct both electrons and ions, multiple stimuli‐responsiveness. However, hydrogels are vulnerable damage, which limits usage in developing durable hydrogel‐based bioelectronics. Self‐healing aim endow with property repairing specific functions after failure, thus improving durability, reliability, longevity. This review discusses recent advances self‐healing hydrogels, from mechanisms, material chemistry, strategies for properties improvement hydrogel materials, design, fabrication, applications bioelectronics, including wearable physical biochemical sensors, supercapacitors, flexible display devices, triboelectric nanogenerators (TENGs), implantable etc. Furthermore, persisting challenges hampering development prospects proposed. is expected expedite research
Language: Английский
Citations
91
ACS Materials Letters, Journal Year: 2023, Volume and Issue: 5(7), P. 1787 - 1830
Published: May 26, 2023
Due to the good reliability and long-term stability, self-healing hydrogels have emerged as promising soft materials for tissue engineering, smart wearable sensors, bioelectronics, energy storage devices. The mechanism depends on reversible chemical or physical cross-linking interactions. Self-healing with fascinating features (including mechanical performances, biocompatibility, conductivity, antibacterial ability, responsiveness, etc.) are being designed developed according practical application requirements. In this review, recent progress in their synthesis strategies multiple applications is summarized. Their involve processes a combination of two. include flexible strain supercapacitors, actuators, adhesives, wound healing, drug delivery, tumor treatment, 3D printing, etc. Finally, current challenges, future development, opportunities discussed.
Language: Английский
Citations
86
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: July 1, 2024
The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.
Language: Английский
Citations
83
ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(14), P. 17562 - 17576
Published: March 6, 2023
Bioactive hydrogels self-assembled from naturally occurring herbal small molecules are attracting growing interest for applications in wound healing, due to their versatile intrinsic biological activities, excellent biocompatibility, as well facile, sustainable, and eco-friendly processes. However, the development of supramolecular herb with sufficient strength multifunctionality an ideal dressing clinical practice remains a challenge. In this work, inspired by efficient clinic therapy directed self-assembly natural saponin glycyrrhizic acid (GA), we create novel GA-based hybrid hydrogel promote full-thickness healing bacterial-infected healing. This possesses stability mechanical performance multifunctional properties, including injectable, shape-adaptation remodeling, self-healing, adhesive abilities. is attributed hierarchical dual-network that comprises hydrogen-bond fibrillar network aldehyde-contained GA (AGA) dynamic covalent through Schiff base reaction between AGA biopolymer carboxymethyl chitosan (CMC). Notably, benefiting inherent strong activity GA, AGA-CMC exhibits unique significant anti-inflammation effects antibacterial ability, especially toward Gram-positive Staphylococcus aureus (S. aureus). vivo experiments demonstrate promotes uninfected skin S. aureus-infected enhancing formation granulation tissue, facilitating collagen deposition, reducing bacterial infection, downregulating inflammatory response. study highlights design new bioactive drug-food homologous molecules, which can serve promising wound-healing biomedical applications.
Language: Английский
Citations
72
Advanced Materials, Journal Year: 2023, Volume and Issue: 36(6)
Published: Nov. 8, 2023
Abstract Gel materials are appealing due to their diverse applications in biomedicine, soft electronics, sensors, and actuators. Nevertheless, the existing synthetic gels often plagued by feeble network structures inherent defects associated with solvents, which compromise mechanical load‐bearing capacity cast persistent doubts about reliability. Herein, combined attractive deep eutectic solvent (DES), a stepwise‐enhanced strategy is presented fabricate ultrarobust eutectogels. It focuses on continuous modulation optimization of polymer networks through complementary annealing exchange processes, drives progressive increase both quantity mass interconnected chains at microscopic scale, hence contributing evolutionary enhancement structure. The resultant eutectogel exhibits superb properties, including record‐breaking strength (31.8 MPa), toughness (76.0 MJ m −3 ), Young's modulus (25.6 together exceptional resistance ability tear crack propagation. Moreover, this able be further programmed photolithography situ create patterned for imparting specific functionalities. Enhanced its broad applicability various DES combinations, poised serve as crucial template methodology future development robust gels.
Language: Английский
Citations
60
Molecules, Journal Year: 2023, Volume and Issue: 28(6), P. 2766 - 2766
Published: March 19, 2023
Over the last decade, efforts have been oriented toward development of suitable gels for 3D printing, with controlled morphology and shear-thinning behavior in well-defined conditions. As a multidisciplinary approach to fabrication complex biomaterials, bioprinting combines cells biocompatible materials, which are subsequently printed specific shapes generate structures regenerative medicine or tissue engineering. A major interest is devoted printing biomimetic materials structural fidelity after their fabrication. Among some requirements imposed bioinks, such as biocompatibility, nontoxicity, possibility be sterilized, nondamaging processability represents critical issue stability functioning constructs. The challenges field printable mimic at different length scales existing nature reproduce functions biological systems. Thus, careful investigation rheological characteristics allows fine-tuning material properties that manufactured targeted applications. fluid-like solid-like conditions similar those encountered additive manufacturing can monitored through viscoelastic parameters determined shear network strength, shear-thinning, yield point, thixotropy govern bioprintability. An assessment these features provides significant insights design characterization gels. This review focuses on bioinspired survey cutting-edge research developing manufacturing.
Language: Английский
Citations
58