Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(32), P. 7692 - 7759
Published: Jan. 1, 2024
Tissue engineering has emerged as a remarkable field aiming to repair or replace damaged tissues through the use of biomimetic constructs.
Language: Английский
Carbon, Journal Year: 2024, Volume and Issue: 223, P. 118970 - 118970
Published: Feb. 26, 2024
Hydrogel-integrated graphene superstructures (GSSs) represent a promising platform for applications in tissue engineering and regenerative medicine. Graphene, two-dimensional carbon-based material, possesses remarkable mechanical, thermal, electrical characteristics, making it strong candidate application biomedicine. Researchers have pursued the integration of with hydrogels, known their biocompatibility ability to provide conducive environment cellular growth, craft sophisticated scaffolds tailored needs. The hydrogels enables construction 3D frameworks that closely mimic natural extracellular matrix (ECM) found biological tissues. Hydrogels furnish biocompatible, well-hydrated environment, while component bolsters scaffold's mechanical integrity conductivity. This amalgamation enhances adhesion, differentiation, proliferation, thereby facilitating regeneration. A notable advantage hydrogel-integrated GSSs lies capacity support growth differentiation variety cell types such as PC12, MG-63, U-87, MC3T3-E1 lines. Overall, exhibit great potential advancing biomimetic combination unique properties development advanced scaffold systems Further research this domain will play crucial role medicine treatment various diseases injuries.
Language: Английский
Citations
30
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(18)
Published: March 23, 2024
Intense and persistent oxidative stress, excessive inflammation, impaired angiogenesis severely hinder diabetic wound healing. Bioactive hydrogel dressings with immunoregulatory proangiogenic properties have great promise in treating wounds. However, the therapeutic effects of always depend on drugs side effects, expensive cytokines, cell therapies. Herein, a novel dynamic borate-bonds crosslinked hybrid multifunctional photothermal are developed to regulate microenvironment sites accelerate whole process its healing without additional medication. The is composed phenylboronic acid-modified chitosan hyaluronic acid (HA) by tannic (TA) through borate bonds Prussian blue nanoparticles (PBNPs) response characteristics embedded polymer networks. results indicate hydrogels show inherent broad-spectrum antioxidative activities integrated interaction bonds, TA, PBNPs. Meanwhile, combined regulation macrophage phenotype HA, inflammatory wounds transformed. Moreover, then enhanced mild effect PBNPs, followed promoted epithelialization collagen deposition. In summary, this system accelerates all stages repair immunomodulation, proangiogenesis, showing potential applications management.
Language: Английский
Citations
30
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)
Published: May 9, 2024
Hydrogels have emerged as promising candidates for biomedical applications, especially in the field of antibacterial therapeutics, due to their unique structural properties, highly tunable physicochemical and excellent biocompatibility. The integration stimuli-responsive functions into hydrogels holds potential enhance properties therapeutic efficacy, dynamically responding different external or internal stimuli, such pH, temperature, enzymes, light. Therefore, this review describes applications hydrogel dressings responsive stimuli therapy. collaborative interaction between materials is discussed. This synergistic approach, contrast conventional materials, not only amplifies effect but also alleviates adverse side effects diminishes incidence multiple infections drug resistance. provides a comprehensive overview current challenges outlines future research directions hydrogels. It underscores imperative ongoing interdisciplinary aimed at unraveling mechanisms wound healing. understanding crucial optimizing design implementation Ultimately, aims offer scientific guidance development practical clinical application dressings.
Language: Английский
Citations
26
Advanced Science, Journal Year: 2024, Volume and Issue: 11(13)
Published: Jan. 19, 2024
Abstract Conductive hydrogels (CHs) have received significant attention for use in wearable devices because they retain their softness and flexibility while maintaining high conductivity. CHs are well suited applications skin‐contact electronics biomedical owing to biocompatibility conformality. Although highly conductive smart extensively researched, a detailed summary of the outstanding results is required comprehensive understanding. In this review, recent progress preparation fabrication summarized devices. Improvements mechanical, electrical, functional properties high‐performance also discussed. Furthermore, examples innovative based on that can be seamlessly integrated into daily lives reviewed.
Language: Английский
Citations
25
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(32), P. 7692 - 7759
Published: Jan. 1, 2024
Tissue engineering has emerged as a remarkable field aiming to repair or replace damaged tissues through the use of biomimetic constructs.
Language: Английский
Citations
23