Interplay of graphene–DNA interactions: Unveiling sensing potential of graphene materials DOI
Yanjing Gao, Yichun Wang

Applied Physics Reviews, Journal Year: 2024, Volume and Issue: 11(1)

Published: Jan. 26, 2024

Graphene-based materials and DNA probes/nanostructures have emerged as building blocks for constructing powerful biosensors. possess exceptional properties, including two-dimensional atomically flat basal planes biomolecule binding. probes serve excellent selective probes, exhibiting specific recognition capabilities toward diverse target analytes. Meanwhile, nanostructures function placement scaffolds, enabling the precise organization of molecular species at nanoscale positioning complex biomolecular assays. The interplay graphene-based has fostered creation intricate hybrid with user-defined architectures. This advancement resulted in significant progress developing novel biosensors detecting DNA, RNA, small molecules, proteins, well sequencing. Consequently, a profound understanding interactions between is key to these biological devices. In this review, we systematically discussed current comprehension interaction materials, elucidated latest advancements probe–graphene-based Additionally, concisely summarized recent research endeavors involving deposition on explored imminent biosensing applications by seamlessly integrating materials. Finally, delineated primary challenges provided prospective insights into rapidly field. We envision that review will aid researchers gaining deeper insight mechanisms DNA–graphene-based biosensors, designing desired applications.

Language: Английский

Nanoscale polymer discs, toroids and platelets: a survey of their syntheses and potential applications DOI

Emma R. L. Brisson,

Max J. H. Worthington, Simran Kerai

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(4), P. 1984 - 2021

Published: Jan. 1, 2024

In this review, we focus on nanoscale polymer discs, toroids, and platelets. We illustrate design rules, group compositions discuss commonly used self-assembly strategies. summarise look ahead to potential applications of these nanomaterials.

Language: Английский

Citations

17
Whispering-Gallery Mode Optoplasmonic Microcavities: From Advanced Single-Molecule Sensors and Microlasers to Applications in Synthetic Biology DOI Creative Commons
Matthew C. Houghton, Samir Vartabi Kashanian, Thomas L. Derrien

et al.

ACS Photonics, Journal Year: 2024, Volume and Issue: 11(3), P. 892 - 903

Published: Feb. 3, 2024

Optical microcavities, specifically, whispering-gallery mode (WGM) with their remarkable sensitivity to environmental changes, have been extensively employed as biosensors, enabling the detection of a wide range biomolecules and nanoparticles. To push limits down most sensitive single-molecule level, plasmonic nanorods are strategically introduced enhance evanescent fields WGM microcavities. This advancement optoplasmonic sensors allows for single molecules protein, conformational even atomic ions, marking significant contributions in sensing. Perspective discusses exciting research prospects sensing molecules, including study enzyme thermodynamics kinetics, emergence thermo-optoplasmonic sensing, ultrasensitive on microlasers, applications synthetic biology.

Language: Английский

Citations

16
Multifunctional DNA-Collagen Biomaterials: Developmental Advances and Biomedical Applications DOI Creative Commons
Nikolaos Pipis, Bryan D. James, Josephine B. Allen

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

The complexation of nucleic acids and collagen forms a platform biomaterial greater than the sum its parts. This union biomacromolecules merges extracellular matrix functionality with designable bioactivity acids, enabling advances in regenerative medicine, tissue engineering, gene delivery, targeted therapy. review traces historical foundations critical applications DNA-collagen complexes highlights their capabilities, demonstrating them as biocompatible, bioactive, tunable materials. These form structures across length scales, including nanoparticles, microfibers, hydrogels, process controlled by relative amount each component type acid collagen. broad distribution different types within body contributes to extensive biological relevance complexes. Functional can these complexes, such siRNA, antisense oligonucleotides, DNA origami nanostructures, and, particular, single-stranded aptamers, often distinguished rapid self-assembly at room temperature formation without external stimuli modifications. simple seamless integration collagenous matrices enhances biomimicry bioactivity, provides stability against enzymatic degradation, positioning an advanced system for many angiogenesis, bone regeneration, wound healing, more.

Language: Английский

Citations

2
DNA tetrahedral nanostructures for the biomedical application and spatial orientation of biomolecules DOI Creative Commons
Weijun Wang,

Mengling Lin,

Wenqing Wang

et al.

Bioactive Materials, Journal Year: 2023, Volume and Issue: 33, P. 279 - 310

Published: Nov. 24, 2023

DNA not only plays a vital role in nature as fundamental hereditary material for storing genetic material, but also serves well-defined functional example, building blocks the assembly of nanoscale bio-architectures by Watson-Crick base-pairing interaction. With development molecular biology, biotechnology and nanoscience, structural nanotechnology has achieved numerous advances, contributing to construction various nanostructures ranging from discrete objects one dimensional (1D), two (2D), three (3D) architectures. Among them, tetrahedral nanoarchitecture is intensively studied because simple 3D structure, easy design unique properties, such high rigidity, desirable biostability efficient cellular uptake without auxiliary species. This review summarizes research progress outlines applications biosensing, drug delivery targeted therapy. Moreover, dependence biological activity biomolecules on tetrahedron-mediated spatially-controlled arrangement great potential are discussed. In addition, challenges clinic tetrahedron-based platforms described, perspectives towards biomedical foreseen, our understandings further studies tetrahedron provided, aiming motivate interdisciplinary research.

Language: Английский

Citations

34
Pros and Cons in Various Immobilization Techniques and Carriers for Enzymes DOI

Yong Jiang,

Jinxia Zheng,

Mengna Wang

et al.

Applied Biochemistry and Biotechnology, Journal Year: 2024, Volume and Issue: 196(9), P. 5633 - 5655

Published: Jan. 4, 2024

Language: Английский

Citations

15
Advancements in Aptamer‐Driven DNA Nanostructures for Precision Drug Delivery DOI Creative Commons
Moein Safarkhani, Sepideh Ahmadi,

Hossein Ipakchi

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(26)

Published: May 7, 2024

Abstract DNA nanostructures exhibit versatile geometries and possess sophisticated capabilities not found in other nanomaterials. They serve as customizable nanoplatforms for orchestrating the spatial arrangement of molecular components, such biomolecules, antibodies, or synthetic This is achieved by incorporating oligonucleotides into design nanostructure. In realm drug delivery to cancer cells, there a growing interest active targeting assays enhance efficacy selectivity. The approach involves “key‐lock” mechanism where carrier, through its ligand, recognizes specific receptors on tumor facilitating release drugs. Various nanostructures, including origami, Tetrahedral, nanoflower, cruciform, nanostar, nanocentipede, nanococklebur, can traverse lipid layer cell membrane, allowing cargo nucleus. Aptamers, easily formed vitro, are recognized their targeted due high selectivity targets low immunogenicity. review provides comprehensive overview recent advancements formation modification aptamer‐modified within systems.

Language: Английский

Citations

15
Nanoparticle-mediated dsRNA delivery for precision insect pest control: a comprehensive review DOI
Nareshkumar Arjunan, T. Venkatesan,

SN Sushil

et al.

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: Feb. 24, 2024

Language: Английский

Citations

13
Bioorthogonal chemistry of polyoxometalates – challenges and prospects DOI Creative Commons
Stanislav K. Petrovskii, Elena V. Grachova, Kirill Yu. Monakhov

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: 15(12), P. 4202 - 4221

Published: Jan. 1, 2024

Bioorthogonal chemistry has enabled scientists to carry out controlled chemical processes in high yields

Language: Английский

Citations

11
DNA-empowered synthetic cells as minimalistic life forms DOI
Avik Samanta, Lorena Baranda Pellejero, Marcos K. Masukawa

et al.

Nature Reviews Chemistry, Journal Year: 2024, Volume and Issue: 8(6), P. 454 - 470

Published: May 15, 2024

Language: Английский

Citations

11
A Review of Recent Developments in Biopolymer Nano-Based Drug Delivery Systems with Antioxidative Properties: Insights into the Last Five Years DOI Creative Commons
Magdalena Stevanović, Nenad Filipović

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(5), P. 670 - 670

Published: May 16, 2024

In recent years, biopolymer-based nano-drug delivery systems with antioxidative properties have gained significant attention in the field of pharmaceutical research. These offer promising strategies for targeted and controlled drug while also providing antioxidant effects that can mitigate oxidative stress-related diseases. Generally, healthcare landscape is constantly evolving, necessitating continual development innovative therapeutic approaches (DDSs). DDSs play a pivotal role enhancing treatment efficacy, minimizing adverse effects, optimizing patient compliance. Among these, nanotechnology-driven garnered due to their unique properties, such as improved solubility, release, delivery. Nanomaterials, including nanoparticles, nanocapsules, nanotubes, etc., versatile platforms tissue engineering applications. Additionally, hold immense promise, leveraging natural or synthetic biopolymers encapsulate drugs enable release. numerous advantages, biocompatibility, biodegradability, low immunogenicity. The utilization polysaccharides, polynucleotides, proteins, polyesters biopolymer matrices further enhances versatility applicability DDSs. Moreover, substances emerged key players combating diseases, offering protection against cellular damage chronic illnesses. nanoformulations represents burgeoning research area, substantial increase publications years. This review provides comprehensive overview developments within this area over past five It discusses various materials, fabrication techniques, stabilizers, factors influencing degradation, it highlights emerging trends, challenges, prospects rapidly evolving field.

Language: Английский

Citations

11