Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 30, 2025
Abstract
Functional
biomaterials
composed
of
multiple
biomacromolecules
have
significant
advantages
over
those
made
from
a
single
type.
However,
harmoniously
integrating
various
remains
challenging.
Neutrophil
extracellular
traps
(NETs),
an
emerging
biological
structure
released
neutrophils,
serve
as
natural
prototype
worth
investigating
and
learning
from.
NETs
consist
intricate
exhibit
web‐like
microstructure,
endowing
them
with
multifaceted
roles
in
both
physiological
pathological
processes.
In
this
review,
research
progress
is
systematically
examined
on
materials
science
perspective.
First,
the
origin
transformation
are
introduced,
their
functional
mechanisms
NET
components
thoroughly
dissected
rather
than
conventionally
treating
entity.
Second,
given
complex
functions,
revealed
potential
biomarker
for
disease
prediction.
Third,
typical
characterization
technologies
analysis
summarized.
Fourth,
artificial
inspired
by
discussed.
addition,
regulatory
processes
provide
bio‐inspired
prototypes
design
advanced
materials.
Finally,
perspectives
opportunities
challenges
advancing
presented
biomarkers
models
development
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(46), P. 31713 - 31736
Published: Nov. 7, 2024
Sensitive
and
quantitative
detection
of
chemical
biological
molecules
for
screening,
diagnosis
monitoring
diseases
is
essential
to
treatment
planning
response
monitoring.
Electrochemical
biosensors
are
fast,
sensitive,
easy
miniaturize,
which
has
led
rapid
development
in
clinical
diagnosis.
Benefiting
from
their
excellent
molecular
recognition
ability
high
programmability,
DNA
nanomaterials
could
overcome
the
Debye
length
electrochemical
by
simple
design
well
suited
as
elements
biosensors.
Therefore,
enhance
sensitivity
specificity
biosensors,
significant
progress
been
made
recent
years
optimizing
design.
Here,
establishment
sensing
strategies
based
on
reviewed
detail.
First,
structural
nanomaterial
examined
improving
overcoming
length.
In
addition,
electrical
signal
transduction
amplification
reviewed,
applications
nanomaterial-based
integrated
devices
further
summarized.
Finally,
main
opportunities
challenges
detecting
disease
biomarkers
presented
an
aim
guide
with
specificity.
Current Opinion in Structural Biology,
Journal Year:
2024,
Volume and Issue:
87, P. 102846 - 102846
Published: June 7, 2024
Since
the
discovery
of
G-quadruplex
(G4)
participation
in
vital
cellular
processes,
regulation
interaction
naturally
occurring
G4s
with
relative
target
proteins
has
emerged
as
a
promising
approach
for
therapeutic
development.
Additionally,
synthetic
strategy
produced
several
oligonucleotide
aptamers,
embodying
G4
module,
which
exhibit
relevant
biological
activity
by
binding
selectively
to
protein.
In
this
context,
G4-protein
structures
available
Protein
Data
Bank
represent
valuable
molecular
view
different
topologies
involved
protein
interaction.
Interestingly,
recent
results
have
shown
co-existence
other
structural
domains
such
duplexes.
Overall,
these
findings
allow
better
understanding
mechanisms
that
regulate
intricate
functions
and
suggest
new
design
innovative
medical
treatments.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(49), P. 19160 - 19182
Published: Nov. 27, 2024
This
Perspective
explores
the
revolutionary
advances
in
wearable
aptasensor
(WA)
technology,
which
combines
devices
and
aptamer-based
detection
systems
for
personalized,
real-time
health
monitoring.
The
leverage
specificity
sensitivity
of
aptamers
to
target
specific
molecules,
offering
broad
applications
from
continuous
glucose
tracking
early
diagnosis
diseases.
integration
data
analytics
artificial
intelligence
(AI)
allows
risk
prediction
guides
preventive
measures.
While
challenges
miniaturization,
power
efficiency,
security
persist,
these
hold
significant
potential
democratize
healthcare
reshape
patient-doctor
interactions.
Cancer Communications,
Journal Year:
2023,
Volume and Issue:
44(2), P. 205 - 225
Published: Dec. 28, 2023
Abstract
Targeted
delivery
of
anti‐tumor
drugs
and
overcoming
drug
resistance
in
malignant
tumor
cells
remain
significant
clinical
challenges.
However,
there
are
only
few
effective
methods
to
address
these
issues.
Extracellular
vesicles
(EVs),
actively
secreted
by
cells,
play
a
crucial
role
intercellular
information
transmission
cargo
transportation.
Recent
studies
have
demonstrated
that
engineered
EVs
can
serve
as
carriers
showed
promising
application
prospects.
Nevertheless,
is
an
urgent
need
for
further
improvements
the
isolation
purification
EVs,
surface
modification
techniques,
assembly
processes,
precise
recognition
targeted
purposes.
In
this
review,
we
summarize
applications
cancer
treatment
resistance,
current
challenges
associated
with
also
discussed.
This
review
aims
provide
new
insights
potential
directions
utilizing
systems
near
future.
European Journal of Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
198, P. 106793 - 106793
Published: May 11, 2024
The
revolutionary
Proteolysis
Targeting
Chimera
(PROTACs)
have
the
exciting
potential
to
reshape
pharmaceutical
industry
landscape
by
leveraging
ubiquitin-proteasome
system
for
targeted
protein
degradation.
Breast
cancer,
most
prevalent
cancer
in
women,
could
be
treated
using
PROTAC
therapy.
Although
substantial
work
has
been
conducted,
there
isn't
yet
a
comprehensive
overview
or
progress
update
on
therapy
breast
cancer.
Hence,
this
article,
we've
compiled
recent
research
focusing
different
target
proteins,
such
as
estrogen
receptor
(ER),
BET,
CDK,
HER2,
PARP,
EZH2,
etc.
This
resource
aims
serve
guide
future
PROTAC-based
treatment
design.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(16), P. 8888 - 8888
Published: Aug. 15, 2024
RNA
is
a
promising
nucleic
acid-based
biomolecule
for
various
treatments
because
of
its
high
efficacy,
low
toxicity,
and
the
tremendous
availability
targeting
sequences.
Nevertheless,
shows
instability
has
short
half-life
in
physiological
environments
such
as
bloodstream
presence
RNAase.
Therefore,
developing
reliable
delivery
strategies
important
disease
sites
maximizing
therapeutic
effect
drugs,
particularly
field
immunotherapy.
In
this
mini-review,
we
highlight
two
major
approaches:
(1)
vehicles
(2)
chemical
modifications.
Recent
advances
employ
nanotechnologies
lipid-based
nanoparticles,
viral
vectors,
inorganic
nanocarriers
to
precisely
target
specific
cell
types
facilitate
cellular
entry.
On
other
hand,
modification
utilizes
alteration
structures
via
addition
covalent
bonds
N-acetylgalactosamine
or
antibodies
(antibody-oligonucleotide
conjugates)
receptors
cells.
The
pros
cons
these
technologies
are
enlisted
review.
We
aim
review
acid
their
systems,
strategies,
related
Finally,
express
our
perspective
on
potential
combination
RNA-based
click
chemistry
with
adoptive
therapy
(e.g.,
B
cells
T
cells)
address
issues
duration
associated
antibody-oligonucleotide
conjugate
drugs.
