Integration of Motion and Stillness: A Paradigm Shift in Constructing Nearly Planar NIR-II AIEgen with Ultrahigh Molar Absorptivity and Photothermal Effect for Multimodal Phototheranostics

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

The two contradictory entities in nature often follow the principle of unity opposites, leading to optimal overall performance. Particularly, aggregation-induced emission luminogens (AIEgens) with donor–acceptor (D–A) structures exhibit tunable optical properties and versatile functionalities, offering significant potential revolutionize cancer treatment. However, trapped by low molar absorptivity (ε) owing distorted configurations, ceilings their photon-harvesting capability corresponding phototheranostic performance still fall short. Therefore, a research paradigm from twisted configuration near-planar structure featuring high ε is urgently needed for AIEgens development. Herein, introducing strategy "motion stillness" into highly planar A–D–A skeleton, we successfully developed near-infrared (NIR)-II AIEgen Y5-2BO-2BTF, which boasts an impressive 1.06 × 105 M–1 cm–1 photothermal conversion efficiency (PCE) 77.8%. modification steric hindrance on benzene ring acceptor unit aggregation-caused quenching counterpart Y5-2BO, meta-CF3-substituted naphthyl, leads reversely staggered packing various intermolecular noncovalent conformational locks Y5-2BO-2BTF ("stillness"). Furthermore, −CF3 moiety acted as flexible motion ultralow energy barrier, significantly facilitating process loose aggregates ("motion"). Accordingly, nanoparticles enabled tumor eradication pulmonary metastasis inhibition through NIR-II fluorescence-photoacoustic-photothermal imaging-navigated type I photodynamic-photothermal therapy. This work provides first evidence that conformation stacking arrangement could serve novel molecular design direction AIEgens, shedding new light constructing superior agents bioimaging

Language: Английский

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Recent advances in reactive small-molecule fluorescent probes for food safety

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 530, P. 216480 - 216480

Published: Feb. 5, 2025

Language: Английский

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Application of a near-infrared viscosity-responsive fluorescent probe for lysosomal targeting in fatty liver mice

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 155, P. 108162 - 108162

Published: Jan. 13, 2025

Language: Английский

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A Triple-Responsive and Dual-NIR Emissive Fluorescence Probe for Precise Cancer Imaging and Therapy by Activating Pyroptosis Pathway

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Revealing changes in the tumor microenvironment is crucial for understanding cancer and developing sensitive methods precise imaging diagnosis. Intracellular hydrogen peroxide (H2O2) microenvironmental factors (e.g., viscosity polarity) are closely linked to various physiological pathological processes, making them potential biomarkers cancer. However, a triple-response theranostic probe therapy has not yet been achieved due lack of effective tools. Herein, we present mitochondria-targeting near-infrared (NIR) fluorescent probe, VPH-5DF, capable simultaneously monitoring H2O2, viscosity, polarity through dual NIR channels. The specifically detects H2O2 via emission (λem = 650 nm) shows high sensitivity viscosity/polarity deep channel ≈ 750 nm). Furthermore, only monitors mitochondrial polarity, fluctuations endogenous/exogenous levels but also distinguishes cells from normal multiple parameters. Additionally, VPH-5DF can be employed monitor alterations levels, as well during drug-induced pyroptosis living cells. After treatment with chemotherapy-induced oxidative damage mitochondria activated pathway, leading robust antitumor response, evidenced xenograft models. Thus, this prodrug offers new platform vivo diagnosis anticancer chemotherapy.

Language: Английский

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Phototherapy: progress, challenges, and opportunities

Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Language: Английский

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Complexity made easy: Aggregation‐induced emission small molecules for cancer diagnosis and phototherapies

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Abstract Phototheranostics has garnered sustained attention due to its significant potential for revolutionizing conventional cancer treatment strategies. While being one of the most commonly employed strategies constructing phototheranostic systems by engineering integration photosensitizers (PSs) into nanosystems, nano‐PSs face challenges including complexity in preparation process, low delivery efficiency, and toxicity issues. Contrastingly, burgeoning popularity small molecule PSs characterized aggregation‐induced emission (AIE) become evident arena phototheranostics. This preference is underscored their well‐defined structures, adjustable photophysical properties, toxicity. Therefore, acquiring profound insights pioneering strides achievable through a solitary PS with AIE tumor phototheranostics paramount scientific significance. In this review, we will discuss recent progress properties diagnosis phototherapies representative examples, guided ethos “Complexity made easy”. We also look forward future development direction molecules, central objective advancing research focal emphasis on simplicity, expeditiousness, safety.

Language: Английский

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Novel activated NIR-II fluorescence/Ratio photoacoustic probe for dual-modality accurate imaging of palladium ions overload in mouse liver

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 470, P. 134275 - 134275

Published: April 10, 2024

Language: Английский

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An ingenious near-infrared fluorescent probe for detection of viscosity in biosystems and beverages

Microchemical Journal, Journal Year: 2025, Volume and Issue: 209, P. 112734 - 112734

Published: Jan. 10, 2025

Language: Английский

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A self-aggregated thermally activated delayed fluorescence nanoprobe for HClO imaging and activatable photodynamic therapy

Talanta, Journal Year: 2025, Volume and Issue: 286, P. 127570 - 127570

Published: Jan. 10, 2025

Language: Английский

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Dual functional nanoplatforms potentiate osteosarcoma immunotherapy via microenvironment modulation

National Science Review, Journal Year: 2025, Volume and Issue: 12(3)

Published: Jan. 10, 2025

Osteosarcoma (OS), a highly aggressive bone tumor, presents significant challenges in terms of effective treatment. We identified that cellular autophagy was impaired within OS by comparing clinical samples through bioinformatic analyses and further validated the inhibition mitochondrial at transcriptomic level. Based on this finding, we investigated therapeutic potential dual functional metal nanoplatform (MnSx) to facilitate transition from protective effect low-level killing high-level OS. MnSx facilitated intracellular H2S generation via endocytosis, leading S-sulfhydration ubiquitin-specific peptidase 8 (USP8) subsequent promotion vitro. Additionally, activated cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator interferon genes (STING) pathway, enhancing autophagic response accelerating tumor cell death. Moreover, it demonstrated vivo MnSx, one hand, mediated activation USP8 H2S, while Mn2+ promoted maturation dendritic cells, cytotoxic T lymphocytes contributed eradication. Such could be suppressed inhibitor chloroquine. Importantly, synergistic combination therapy with immune checkpoint inhibitors showed promise for achieving complete remission This study highlights as dual-functional platform treatment offers novel directions future research field.

Language: Английский

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