Developmental medico-life-sciences,
Journal Year:
2024,
Volume and Issue:
1(10), P. 4 - 22
Published: Dec. 13, 2024
Ovarian
cancer
is
one
of
the
most
aggressive
and
deadly
gynaecological
malignancies
remains
frequently
diagnosed
at
advanced
stages
because
its
asymptomatic
progression
inherent
limitations
current
diagnostic
tests.
Nanoenzymes
(a
class
nanotechnology-based
artificial
enzymes)
have
great
promise
in
addressing
these
challenges.
greatly
improve
sensitivity
specificity
biosensors
including
optical
electrochemical
systems,
with
real-time
high-precision
detection
key
biomarkers
such
as
CA-125,
HE4,
mesothelin.
The
high
accuracy
biosensors,
fluorescence
surface
plasmon
resonance
(SPR)
based
technologies,
for
early-stage
diagnosis,
cost-effective,
portable,
ultra-low
limits
make
them
attractive
alternatives.
Nanoenzyme-based
drug
delivery
systems
like
liposomes,
polymeric
micelles,
Nanocapsules
therapeutic
outcomes
by
allowing
targeted
transport
to
tumor
tissues,
reducing
systemic
toxicity,
overcoming
resistance
treatment.
PEGylated
liposomal
doxorubicin
(Doxil),
a
formulation,
has
been
shown
enhanced
efficacy
platinum-resistant
ovarian
cancer,
reduced
adverse
effects.
Further
theranostic
applications
metallic
nanoparticles
gold
iron
oxide
can
be
realized
using
therapy
imaging.
These
advancements
come
their
challenges,
however,
biological
barriers,
scalability
before
clinical
translation.
Interdisciplinary
research,
validation,
creation
regulatory
frameworks
safety
are
needed
future
progress.
offer
revolutionize
diagnosis
treatment
potential
facilitate
early
detection,
precision,
patient
outcome
while
filling
huge
gaps
approaches.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 8, 2024
Abstract
Sonothermal
therapy
(STT)
has
become
increasingly
attractive
recently
as
a
noninvasive,
safe,
and
nonionizing
methodology.
STT,
newly
emerging
heat‐enabled
therapeutic
approach,
can
rely
on
built‐in
bubble
cavitation
thermal
energy‐electron
recombination
of
sonothermal
agents
(STAs)
activated
by
ultrasound
(US)
irradiation.
In
this
domain,
STT‐enabled
nanomedicine
is
considered
potential
treatment
for
abnormal
cell
killing
normal
renewing,
which
addresses
the
drawbacks
nonspecific
heating
in
conventional
microbubbles,
side
effects,
poor
tissue
penetration
available
thermal‐based
therapies.
Herein,
comprehensive
review
efficiency
STT
tumor
ablation,
infection
therapy,
regeneration
presented.
Moreover,
focuses
benefits
hot
topic
that
be
used
nonantibiotic
treatments,
noninvasive
heat‐activated
regeneration,
highly
efficient
local
cancer
therapy.
addition,
rational
design
STAs,
mechanistic
innovations,
prospects
will
also
provided.
Developmental medico-life-sciences,
Journal Year:
2024,
Volume and Issue:
1(10), P. 4 - 22
Published: Dec. 13, 2024
Ovarian
cancer
is
one
of
the
most
aggressive
and
deadly
gynaecological
malignancies
remains
frequently
diagnosed
at
advanced
stages
because
its
asymptomatic
progression
inherent
limitations
current
diagnostic
tests.
Nanoenzymes
(a
class
nanotechnology-based
artificial
enzymes)
have
great
promise
in
addressing
these
challenges.
greatly
improve
sensitivity
specificity
biosensors
including
optical
electrochemical
systems,
with
real-time
high-precision
detection
key
biomarkers
such
as
CA-125,
HE4,
mesothelin.
The
high
accuracy
biosensors,
fluorescence
surface
plasmon
resonance
(SPR)
based
technologies,
for
early-stage
diagnosis,
cost-effective,
portable,
ultra-low
limits
make
them
attractive
alternatives.
Nanoenzyme-based
drug
delivery
systems
like
liposomes,
polymeric
micelles,
Nanocapsules
therapeutic
outcomes
by
allowing
targeted
transport
to
tumor
tissues,
reducing
systemic
toxicity,
overcoming
resistance
treatment.
PEGylated
liposomal
doxorubicin
(Doxil),
a
formulation,
has
been
shown
enhanced
efficacy
platinum-resistant
ovarian
cancer,
reduced
adverse
effects.
Further
theranostic
applications
metallic
nanoparticles
gold
iron
oxide
can
be
realized
using
therapy
imaging.
These
advancements
come
their
challenges,
however,
biological
barriers,
scalability
before
clinical
translation.
Interdisciplinary
research,
validation,
creation
regulatory
frameworks
safety
are
needed
future
progress.
offer
revolutionize
diagnosis
treatment
potential
facilitate
early
detection,
precision,
patient
outcome
while
filling
huge
gaps
approaches.
