Glucose-oxidase like catalytic mechanism of noble metal nanozymes

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: June 7, 2021

Abstract Au nanoparticles (NPs) have been found to be excellent glucose oxidase mimics, while the catalytic processes rarely studied. Here, we reveal that process of oxidation catalyzed by NPs is as same natural oxidase, namely, a two-step reaction including dehydrogenation and subsequent reduction O 2 H two electrons. Pt, Pd, Ru, Rh, Ir can also catalyze glucose, except preferably reduced O. By electron transfer feature noble metal NPs, overcame limitation must produced in traditional assay realize rapid colorimetric detections glucose. Inspired transport pathway enzymes, mimic various enzymatic reactions cytochrome c, coenzymes well nitrobenzene reductions.

Language: Английский

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Redox Signaling by Reactive Electrophiles and Oxidants

Chemical Reviews, Journal Year: 2018, Volume and Issue: 118(18), P. 8798 - 8888

Published: Aug. 27, 2018

The concept of cell signaling in the context nonenzyme-assisted protein modifications by reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely complex topic that has been approached from numerous different multidisciplinary angles. Our Review reflects on five aspects critical for understanding how nature harnesses these noncanonical post-translational to coordinate distinct cellular activities: (1) specific players their generation, (2) physicochemical properties, (3) mechanisms action, (4) methods interrogation, (5) functional roles health disease. Emphasis primarily placed latest progress field, but several classical work likely forgotten/lost are also recollected. For researchers with interests getting into our anticipated function primer. expert, we aim stimulate thought discussion about fundamentals nuances specificity/selectivity timing this sophisticated yet fascinating arena at crossroads chemistry biology.

Language: Английский

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Formation and Cleavage of C–C Bonds by Enzymatic Oxidation–Reduction Reactions

Chemical Reviews, Journal Year: 2018, Volume and Issue: 118(14), P. 6573 - 6655

Published: June 22, 2018

Many oxidation–reduction (redox) enzymes, particularly oxygenases, have roles in reactions that make and break C–C bonds. The list includes cytochrome P450 other heme-based monooxygenases, dioxygenases, nonheme iron mono- flavoproteins, radical S-adenosylmethionine copper peroxidases. Reactions involve steroids, intermediary metabolism, secondary natural products, drugs, industrial agricultural chemicals. bonds are formed via either (i) coupling of diradicals or (ii) generation unstable products rearrange. cleavage several themes: rearrangement oxidized produced by the oxidation collapse radicals cations rearrangement, (iii) oxygenation to yield readily hydrolyzed (iv) activation O2 systems which binding a substrate facilitates activation. enzymes metals, but these, is clearly predominant.

Language: Английский

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Oxygen and ROS in Photosynthesis

Plants, Journal Year: 2020, Volume and Issue: 9(1), P. 91 - 91

Published: Jan. 10, 2020

Oxygen is a natural acceptor of electrons in the respiratory pathway aerobic organisms and many other biochemical reactions. Aerobic metabolism always associated with formation reactive oxygen species (ROS). ROS may damage biomolecules but are also involved regulatory functions photosynthetic organisms. This review presents main properties ROS, electron transport chain stroma chloroplasts, scavenging systems thylakoid membrane stroma. Effects on apparatus their roles redox signaling discussed.

Language: Английский

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Baeyer–Villiger Monooxygenases: Tunable Oxidative Biocatalysts

ACS Catalysis, Journal Year: 2019, Volume and Issue: 9(12), P. 11207 - 11241

Published: Oct. 25, 2019

Pollution, accidents, and misinformation have earned the pharmaceutical chemical industry a poor public reputation, despite their undisputable importance to society. Biotechnological advances hold promise enable future of drastically reduced environmental impact rigorously more efficient production routes at same time. This is exemplified in Baeyer–Villiger reaction, which offers simple synthetic route oxidize ketones esters, but application hampered by requirement hazardous dangerous reagents. As an attractive alternative, flavin-containing monooxygenases (BVMOs) been investigated for potential as biocatalysts long time, many variants characterized. After general look state biotechnology, we here summarize literature on biochemical characterizations, mechanistic structural investigations, well enzyme engineering efforts BVMOs. With focus recent developments, critically outline toward tuning these enzymes suitable industrial applications.

Language: Английский

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Charge Transfer and Biocompatibility Aspects in Conducting Polymer-Based Enzymatic Biosensors and Biofuel Cells

Nanomaterials, Journal Year: 2021, Volume and Issue: 11(2), P. 371 - 371

Published: Feb. 2, 2021

Charge transfer (CT) is a very important issue in the design of biosensors and biofuel cells. Some nanomaterials can be applied to facilitate CT these bioelectronics-based devices. In this review, we overview some mechanisms and/or pathways that are most frequently established between redox enzymes electrodes. Facilitation indirect by application electrochemical enzymatic More sophisticated still rather rarely observed direct charge (DCT), which often addressed as electron (DET), therefore, DCT/DET also targeted discussed review. The conducting polymers (CPs) for immobilization facilitation during cells overviewed. Significant attention paid various ways synthesis such polyaniline, polypyrrole, polythiophene poly(3,4-ethylenedioxythiophene). CP-based sensors discussed, taking into account not only

Language: Английский

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Recent advances in molecular oxygen activation via photocatalysis and its application in oxidation reactions

Chemical Engineering Journal, Journal Year: 2021, Volume and Issue: 421, P. 129915 - 129915

Published: April 24, 2021

Language: Английский

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Magnetic field effects in biology from the perspective of the radical pair mechanism

Journal of The Royal Society Interface, Journal Year: 2022, Volume and Issue: 19(193)

Published: Aug. 1, 2022

Hundreds of studies have found that weak magnetic fields can significantly influence various biological systems. However, the underlying mechanisms behind these phenomena remain elusive. Remarkably, energies implicated in effects are much smaller than thermal energies. Here, we review observations, and suggest an explanation based on radical pair mechanism, which involves quantum dynamics electron nuclear spins transient molecules. While mechanism has been studied detail context avian magnetoreception, reviewed here show magnetosensitivity is widespread throughout biology. We field physiological functions, discussing static, hypomagnetic oscillating fields, as well isotope effects. then a potential unifying model for described effects, discuss plausible candidate molecules pairs. recent proposing provides explanations xenon anaesthesia lithium treatment hyperactivity, circadian clock, neurogenesis microtubule assembly. conclude by future lines investigation this exciting new area

Language: Английский

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Flavoprotein monooxygenases: Versatile biocatalysts

Biotechnology Advances, Journal Year: 2021, Volume and Issue: 51, P. 107712 - 107712

Published: Feb. 15, 2021

Flavoprotein monooxygenases (FPMOs) are single- or two-component enzymes that catalyze a diverse set of chemo-, regio- and enantioselective oxyfunctionalization reactions. In this review, we describe how FPMOs have evolved from model in mechanistic flavoprotein research to biotechnologically relevant catalysts can be applied for the sustainable production valuable chemicals. After historical account development FPMO field, explain classification system, which is primarily based on protein structural properties electron donor specificities. We then summarize most appealing reactions catalyzed by each group with focus different types oxygenation chemistries. Wherever relevant, report engineering strategies been used improve robustness applicability FPMOs.

Language: Английский

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Surface Boronizing Can Weaken the Excitonic Effects of BiOBr Nanosheets for Efficient O₂ Activation and Selective NO Oxidation under Visible Light Irradiation

Environmental Science & Technology, Journal Year: 2022, Volume and Issue: 56(20), P. 14478 - 14486

Published: Sept. 29, 2022

The photocatalytic O2 activation for pollutant removal highly depends on the controlled generation of desired reactive oxygen species (ROS). Herein, we demonstrate that robust excitonic effect BiOBr nanosheets, which is prototypical singlet (1O2) production to partially oxidize NO into a more toxic intermediate NO2, can be weakened by surface boronizing via inducing staggered band alignment from bulk and simultaneously generating vacancy (VO). destabilizes excitons facilitates their dissociation charge carriers, while VO traps electrons efficiently activates superoxide radical (•O2-) one-electron-transfer pathway. Different 1O2, •O2- enables complete oxidation nitrate with high selectivity desirable safe indoor remediation under visible light irradiation. This study provides facile manipulating method layered two-dimensional photocatalysts sheds importance managing ROS efficient removal.

Language: Английский

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