3D printing of hydrogels: Rational design strategies and emerging biomedical applications

Materials Science and Engineering R Reports, Journal Year: 2020, Volume and Issue: 140, P. 100543 - 100543

Published: Feb. 18, 2020

3D printing alias additive manufacturing can transform virtual models created by computer-aided design (CAD) into physical objects in a layer-by-layer manner dispensing with conventional molding or machining. Since the incipiency, significant advancements have been achieved understanding process of and relationship component, structure, property application objects. Because hydrogels are one most feasible classes ink materials for this field has rapidly advancing, Review focuses on hydrogel designs development advanced hydrogel-based biomaterial inks bioinks printing. It covers techniques including laser (stereolithography, two-photon polymerization), extrusion (3D plotting, direct writing), inkjet printing, bioprinting, 4D bioprinting. provides comprehensive overview discussion tailorability material, mechanical, physical, chemical biological properties to enable The range hydrogel-forming polymers covered encompasses biopolymers, synthetic polymers, polymer blends, nanocomposites, functional cell-laden systems. representative biomedical applications selected demonstrate how is being exploited tissue engineering, regenerative medicine, cancer research, vitro disease modeling, high-throughput drug screening, surgical preparation, soft robotics flexible wearable electronics. Incomparable thermoplastics, thermosets, ceramics metals, playing pivotal role creation (bio)systems customizable way. An outlook future directions presented.

Language: Английский

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Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials

Chemical Reviews, Journal Year: 2020, Volume and Issue: 120(24), P. 13135 - 13272

Published: Oct. 30, 2020

Photoactivatable (alternatively, photoremovable, photoreleasable, or photocleavable) protecting groups (PPGs), also known as caged photocaged compounds, are used to enable non-invasive spatiotemporal photochemical control over the release of species interest. Recent years have seen development PPGs activatable by biologically and chemically benign visible near-infrared (NIR) light. These long-wavelength-absorbing moieties expand applicability this powerful method its accessibility non-specialist users. This review comprehensively covers organic transition metal-containing photoactivatable compounds (complexes) that absorb in visible- NIR-range various leaving gasotransmitters (carbon monoxide, nitric oxide, hydrogen sulfide). The text NIR-light-induced photosensitized using molecular sensitizers, quantum dots, upconversion second-harmonic nanoparticles, well via photodynamic (photooxygenation singlet oxygen) photothermal effects. Release from polymers, micelles, vesicles, photoswitches, along with related emerging field photopharmacology, is discussed at end review.

Language: Английский

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Hydrogel scaffolds for tissue engineering: the importance of polymer choice

Polymer Chemistry, Journal Year: 2019, Volume and Issue: 11(2), P. 184 - 219

Published: Sept. 25, 2019

We explore the design and synthesis of hydrogel scaffolds for tissue engineering from perspective underlying polymer chemistry. The key polymers, properties architectures used, their effect on growth are discussed.

Language: Английский

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3D Extracellular Matrix Mimics: Fundamental Concepts and Role of Materials Chemistry to Influence Stem Cell Fate

Biomacromolecules, Journal Year: 2020, Volume and Issue: 21(6), P. 1968 - 1994

Published: March 31, 2020

Synthetic 3D extracellular matrices (ECMs) find application in cell studies, regenerative medicine, and drug discovery. While cells cultured a monolayer may exhibit unnatural behavior develop very different phenotypes genotypes than vivo, great efforts materials chemistry have been devoted to reproducing vitro vivo microenvironments. This requires fine-tuning the biochemical structural actors synthetic ECMs. review will present fundamentals of ECM, cover chemical features scaffolds used generate ECM mimics, discuss nature signaling biomolecules required exploited bioresponsive microenvironments able induce specific fate, highlight strategies involved creating functional mimics.

Language: Английский

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Cu(I)-Catalyzed Click Chemistry in Glycoscience and Their Diverse Applications

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(13), P. 7638 - 7956

Published: June 24, 2021

Copper(I)-catalyzed 1,3-dipolar cycloaddition between organic azides and terminal alkynes, commonly known as CuAAC or click chemistry, has been identified one of the most successful, versatile, reliable, modular strategies for rapid regioselective construction 1,4-disubstituted 1,2,3-triazoles diversely functionalized molecules. Carbohydrates, an integral part living cells, have several fascinating features, including their structural diversity, biocompatibility, bioavailability, hydrophilicity, superior ADME properties with minimal toxicity, which support increased demand to explore them versatile scaffolds easy access diverse glycohybrids well-defined glycoconjugates complete chemical, biochemical, pharmacological investigations. This review highlights successful development chemistry in emerging areas glycoscience, synthesis triazole appended carbohydrate-containing molecular architectures (mainly glycohybrids, glycoconjugates, glycopolymers, glycopeptides, glycoproteins, glycolipids, glycoclusters, glycodendrimers through forming bio-orthogonal coupling protocols). It discusses widespread applications these glycoproducts enzyme inhibitors drug discovery development, sensing, gelation, chelation, glycosylation, catalysis. also covers impact provides future perspectives on its role various disciplines science technology.

Language: Английский

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All Wrapped up: Stabilization of Enzymes within Single Enzyme Nanoparticles

Journal of the American Chemical Society, Journal Year: 2019, Volume and Issue: 141(7), P. 2754 - 2769

Published: Jan. 9, 2019

Enzymes are extremely useful in many industrial and pharmaceutical areas due to their ability catalyze reactions with high selectivity. In order extend lifetime, significant efforts have been made increase stability using protein- or medium engineering as well by chemical modification. Many researchers explored the immobilization of enzymes onto carriers, entrapment within a matrix, framework nanoparticle hope constricting movement enzyme shielding it from aggressive environments, thus delaying denaturation. These strategies often balance three competing interests: (i) maintaining enzymatic activity, (ii) ensuring good long-term against temperature, dehydration, organic solvents, pH, (iii) enabling tuning reversible switching activity. most cases, multiple will be contained single but recent years begun wrap up individual nanoparticles (SENs). these is stabilized thin shell, typically polymer, prepared either situ polymerization surface assembling preformed polymer around it. Because increased control over environment directly enzyme, possibility more controlling substrate diffusion, SENs show remarkable while retaining initial activities even for quite fragile enzymes. Moreover, activity can easily fine-tuned adjusting layer properties. We postulate that this emerging field offer exciting elegant opportunities both catalytic lifetime temperatures enable switched on off demand modulation outer material layer.

Language: Английский

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Near-infrared light and tumor microenvironment dual responsive size-switchable nanocapsules for multimodal tumor theranostics

Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)

Published: Sept. 27, 2019

Smart drug delivery systems (SDDSs) for cancer treatment are of considerable interest in the field theranostics. However, developing SDDSs with early diagnostic capability, enhanced and efficient biodegradability still remains a scientific challenge. Herein, we report near-infrared light tumor microenvironment (TME), dual responsive as well size-switchable nanocapsules. These nanocapsules made PLGA-polymer matrix coated Fe/FeO core-shell nanocrystals co-loaded chemotherapy photothermal agent. Smartly engineered can not only shrink decompose into small-sized nanodrugs upon release but also regulate TME to overproduce reactive oxygen species synergistic therapy tumors. In vivo experiments demonstrate that these target sites through fluorescence/magnetic resonance imaging offer remarkable therapeutic results. Our synthetic strategy provides platform next generation smart permeability retention effect, multimodal anticancer theranostics, biodegradability.

Language: Английский

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Advances in Growth Factor Delivery for Bone Tissue Engineering

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(2), P. 903 - 903

Published: Jan. 18, 2021

Shortcomings related to the treatment of bone diseases and consequent tissue regeneration such as transplants have been addressed some extent by engineering regenerative medicine. Tissue has promoted structures that can simulate extracellular matrix are capable guiding natural repair using signaling molecules promote osteoinduction angiogenesis essential in formation new tissues. Although recent studies on developing novel growth factor delivery systems for attracted great attention, taking into account complexity matrix, scaffolding factors should not be explored independently. Consequently, combine both concepts potential effectiveness methods. In this review, developments simultaneously consider covered detail. The main emphasis overview is strategies employ polymer-based scaffolds spatiotemporal-controlled single multiple bone-regeneration approaches. From clinical applications creating alternative structural materials, advancing constantly, it relevant regularly update topics.

Language: Английский

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Engineering the drug carrier biointerface to overcome biological barriers to drug delivery

Advanced Drug Delivery Reviews, Journal Year: 2020, Volume and Issue: 167, P. 89 - 108

Published: June 11, 2020

Language: Английский

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(Macro)molecular self-assembly for hydrogel drug delivery

Advanced Drug Delivery Reviews, Journal Year: 2021, Volume and Issue: 172, P. 275 - 295

Published: Jan. 13, 2021

Language: Английский

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